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Filtered Search Results
![Medchemexpress LLC 1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo- | 1262417-51-5 | 99.5% | 395.42 | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000385759-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo- | 1262417-51-5 | 99.5% | 395.42 | 200 MG
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NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor for cancer therapy. It is for research use only and not sold to patients.
- Potent PARP-1 inhibitor (Kd=0.009 μM) with 150-fold selectivity over PARP-2 (Kd=1.39 μM).
- Less myelotoxic in vitro compared to olaparib.
- Metabolically stable.
- Modestly inhibits CYP-2B6 (IC50: 8.15 μM) and CYP-2D6 (IC50: 9.51 μM) out of eight isoforms tested.
- Possesses excellent pharmacokinetic profile and nearly complete oral bioavailability in mice and rats.
- Highly efficacious in vivo as a single agent in MDA-MB-436 human breast cancer tumors and in combination with temozolomide in CAPAN-1 human pancreatic tumors.
- Well tolerated at highly efficacious doses and has an excellent ADME profile.
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Medchemexpress LLC Veliparib dihydrochloride | 912445-05-7 | 100.0% | 317.21 g/mol | C13H18Cl2N4O | 200 MG
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Veliparib dihydrochloride is the dihydrochloride salt of veliparib, a small-molecule inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 used in biochemical and cell-based research to probe DNA damage response and repair pathways. Supplied as a high-purity solid, it is intended for mechanistic studies and preclinical research applications.
- Potent inhibitor of PARP1 and PARP2 with Kis of 5.2 nM and 2.9 nM.
- High reported purity suitable for research use (99.98%).
- Well characterized molecular properties (MW 317.21 g/mol, formula C13H18Cl2N4O).
- Suitable for biochemical and cell-based assays investigating DNA repair.
- Available in milligram to gram quantities for diverse experimental needs.
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TARGETMOL CHEMICALS INC Chloroquinoxaline sulfonamide
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Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Chloroquinoxaline sulfonamide (Chloroquinoxaline) is a topoisomerase II alpha/beta toxin with antitumor activity and immunosuppressive properties that inhibits the proliferation of B16 melanoma cells in mice, and can be used to study metastatic colorectal cancer. It can be used to study metastatic colorectal cancer. Purity 98.67%
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PFALTZ & BAUER INC 3 3 -DIETHYLOXATRICARBOC 200MG
NC3835963 3 3 -DIETHYLOXATRICARBOC 200MG
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Medchemexpress LLC 2-Aminoquinoline | 580-22-3 | 144.17 | 1 ML
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2-Aminoquinoline (2-Quinolinamine) is a promising compound as a bioavailable nNOS inhibitor. It exhibits antiviral activity against the vaccinia virus and has potential for the research of antineurodegenerative agents. However, it suffers from low human nNOS inhibition, low selectivity versus human eNOS, and significant binding to other CNS targets.
- Bioavailable nNOS inhibitor
- Antiviral activity against vaccinia virus
- Potential for antineurodegenerative agent research
- Low human nNOS inhibition
- Low selectivity versus human eNOS
- Significant binding to other CNS targets
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000596826 DORDAVIPRONE 200MG
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Medchemexpress LLC Guanidinoethyl sulfo 25mg | 25MG
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Guanidinoethyl sulfo 25mg | 25MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000377939 CDK2-IN-31 1MG
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Medchemexpress LLC Pizotifen | 15574-96-6 | MFCD00864192 | 99.6% | C19H21NS | 200 MG
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Pizotifen, also known as Pizotyline, is a potent 5-HT2 receptor antagonist with high affinity for the 5-HT1C binding site. It is also recognized for its antidepressant properties, specifically as a 5-HT2A receptor antagonist.
- Acts as a potent 5-HT2 receptor antagonist.
- Shows strong affinity for the 5-HT1C binding site.
- Functions as an antidepressant 5-HT2A receptor antagonist.
- Capable of inhibiting serotonin-enhanced ADP-induced platelet aggregation.
- Studies have shown no significant differences in implantations, live, dead fetuses, resorptions, or the occurrence of external, skeletal, and visceral anomalies compared to control groups.
- No significant differences in chromosome aberrations in bone marrow cells of treated mice.
- No elevation in micronuclei frequency in the micronucleus test.
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Medchemexpress LLC Tertiapin-Q | 910044-56-3 | 99.8% | 2452.00 | 1 MG
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Tertiapin-Q is a highly selective blocker of G protein-coupled inwardly rectifying potassium (GIRK1/4) heterodimer and renal outer medullary potassium channel (ROMK1/Kir1.1). It also potently and selectively blocks Kir3.1-Kir3.4 channels and calcium activated large conductance potassium channels. Tertiapin-Q significantly prolongs the atrial effective refractory period in control and rapid atrial pacing rabbits, with a greater effect in the latter. Additionally, it acts as a muscarinic acetylcholine receptor-operated K+ current (IK,Ach) blocker.
- Highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1)
- Potently blocks Kir3.1-Kir3.4 channels and calcium activated large conductance potassium channels
- Prolongs atrial effective refractory period
- Acts as a muscarinic acetylcholine receptor-operated K+ current blocker
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000656263 AF488 AMINE 25MG
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Selleck Chemical LLC Dihydroethidium
Dihydroethidium (DHE HE Hydroethidine PD-MY 003) is a cell-permeable blue fluorogenic probe used for detecting intracellular superoxide radical anion
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Apexbio Technology LLC IAA-94 54197-31-8 5mg
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IAA-94 (CAS 54197-31-8) is a small-molecule inhibitor of epithelial chloride channels modulating cellular electrophysiological properties by disrupting chloride ion transport Experimental studies have demonstrated that IAA-94 can interfere with interactions involving the negative factor (Nef) protein during infection indicating its capacity to modulate Nef-mediated processes Due to its specificity in targeting chloride channels IAA-94 is widely utilized in investigations of ion channel-related signaling pathways in tumor cells and serves as a valuable tool in studies of cell electrophysiology and infection mechanisms
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000383580 CLOBETASOL PROPIONAT 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000383506 SRS16-86 25MG
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