Quinolines and derivatives
Medchemexpress LLC Hydroquinidine | 1435-55-8 | 99.9% | 1 ML
Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that demonstrates strong anti-cancer activity against colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and possesses antiarrhythmic efficacy.
- Potent ion channel blocker
- Exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Possesses antiarrhythmic efficacy
- For research use only
Medchemexpress LLC Hydroquinidine | 1435-55-8 | 100.0% | 25 G
Hydroquinidine, also known as Dihydroquinidine, is a potent ion channel blocker with demonstrated anti-cancer activity against colon, pancreatic, and hepatocellular cancer cells. It is also known to prolong the QT interval and exhibit antiarrhythmic efficacy.
- Potent ion channel blocker
- Demonstrates strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Exhibits antiarrhythmic efficacy
- Molecular formula: C20H26N2O2
- Molecular weight: 326.44
- Appearance: White to off-white solid
- For research use only
Medchemexpress LLC Hydroquinidine | 1435-55-8 | 100.0% | 1 G
Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker with strong anti-cancer activity across colon, pancreatic, and hepatocellular cancer cells. It is also known for its ability to prolong the QT interval and demonstrates antiarrhythmic efficacy.
- Potent ion channel blocker
- Exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Shows antiarrhythmic efficacy
- Demonstrates anti-clonogenic and anti-tumorigenic activities in pancreatic cancer cells
- Modulates gene expression, increasing CDKN1A, CDKN1B, and PUMA
- Reduces expression of BIRC5, AKT, MKI67, PCNA, and CCNE1 in various cancer cell lines
Medchemexpress LLC Hydroquinidine | 1435-55-8 | 99.97% | 5 G
Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and demonstrates antiarrhythmic efficacy.
- Potent ion channel blocker
- Strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Antiarrhythmic efficacy
- For research use only
Medchemexpress LLC Hydroquinidine (Dihydroquinidine) | 1435-55-8 | 99.9% | 50 G
Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that demonstrates strong anti-cancer activity against colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and possesses antiarrhythmic efficacy.
- Exhibits anti-clonogenic and anti-tumorigenic activities in pancreatic cancer cells in vitro.
- Gene expression profiling shows changes in CDKN1A, CDKN1B, PUMA, BIRC5, AKT, MKI67, PCNA, and CCNE1 in various cancer cell lines.
- Investigated for Brugada Syndrome in a Phase 3 clinical trial.
eMolecules 6-HYDROXYQUINOLINE-8-CARBOXYLICACID | 70585-55-6 | MFCD12024807 | 0.25g
AstaTech | 6-HYDROXYQUINOLINE-8-CARBOXYLICACID | 0.25g | 449771839 | K10277 | 95.000 | 70585-55-6 | MFCD12024807 | 189.170 | C10H7NO3
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Medchemexpress LLC CP 339818 (hydrochloride) | 478341-55-8 | 99.6% | 340.89 | 1 MG
CP 339818 hydrochloride is a non-peptide blocker of Kv1.3 (IC50 = 200 nM) and Kv1.4 channels. It also inhibits HCN channels with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl-), respectively. The compound exhibits significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. It can be utilized for studying the physiological functions of HCN and Kv channels.
- Non-peptide Kv1.3 and Kv1.4 channel blocker.
- Inhibits HCN channels (HCN1 and HCN4).
- Selectively blocks Kv1.3, inhibiting human T cell activation.
- Useful for studying physiological functions of HCN and Kv channels.
- Suppresses human T cell activation.
- Effectively blocks remaining outward potassium current in Kv2.1⁻/⁻ β cells.
- Inhibitory effect on HCN1 and HCN4 is weakened in low-concentration Cl- internal solution and is voltage-dependent.
Medchemexpress LLC CP 339818 (hydrochloride) | 478341-55-8 | 99.6% | 340.89 | 25 MG
CP 339818 hydrochloride is a non-peptide blocker for Kv1.3 and Kv1.4 channels. It also inhibits HCN channels and exhibits significantly weaker blocking effects on several other Kv channels. This compound selectively blocks Kv1.3, thereby inhibiting the activation process of human T cells, and is useful for studying the physiological functions of HCN and Kv channels.
- Kv1.3 channel blocker (IC50 = 200 nM).
- Kv1.4 channel blocker.
- Inhibits HCN channels (HCN1 and HCN4).
- Selectively inhibits human T cell activation.
- Suitable for studying physiological functions of HCN and Kv channels.
Medchemexpress LLC CP 339818 hydrochloride | 478341-55-8 | 99.6% | 340.89 | 1 ML
CP 339818 hydrochloride is a non-peptide blocker of Kv1.3 (IC50 = 200 nM) and Kv1.4 channels. It also inhibits HCN channels with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl-), respectively. The compound exhibits significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. It selectively blocks Kv1.3, which in turn inhibits the activation process of human T cells. CP 339818 hydrochloride can be utilized for studying the physiological functions of HCN and Kv channels. For research use only, not for sale to patients.
- Non-peptide blocker of Kv1.3 and Kv1.4 channels.
- Inhibits HCN1 and HCN4 channels.
- Selectively blocks Kv1.3, inhibiting human T-cell activation.
- Useful for studying physiological functions of HCN and Kv channels.
Medchemexpress LLC CP 339818 hydrochloride | 478341-55-8 | 99.6% | 340.89 g/mol | C21H25ClN2 | 5 MG
CP 339818 hydrochloride is a small-molecule, non-peptide ion-channel inhibitor used in electrophysiology and pharmacology research. It blocks Kv1.3 and Kv1.4 channels and inhibits HCN channels, making it useful for studying Kv- and HCN-mediated currents and T-cell activation.
- Non-peptide Kv1.3 and Kv1.4 channel blocker.
- Inhibits HCN channel isoforms with micromolar potency.
- High-purity white to off-white solid suitable for research use.
- Soluble in DMSO up to 62.5 mg/mL.
- Store sealed at 4°C; in solution, keep at -80°C (up to 6 months) or -20°C (up to 1 month).
- Molecular weight 340.89 g/mol; formula C21H25ClN2.
Medchemexpress LLC Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)- | 1435-55-8 | 99.97% | 10 G
Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and demonstrates antiarrhythmic efficacy.
- Strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Demonstrates antiarrhythmic efficacy
- Has anti-clonogenic and anti-tumorigenic activities on pancreatic cancer cells in vitro
- For research use only
eMolecules 3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide | 2003260-55-5 | MFCD31382180 | 10mg
Ambeed | 3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide | 10mg | 552759707 | A860757 | | 2003260-55-5 | MFCD31382180 | 382.463 | C25H22N2O2
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