Quinolines and derivatives
Apexbio Technology LLC Rucaparib (AG-014699,PF-01367338) 459868-92-9 200mg
Rucaparib (AG-014699 PF-01367338 CAS 459868-92-9) is a small molecule inhibitor targeting poly(ADP-ribose) polymerase (PARP) a nuclear enzyme activated by DNA damage and central to the base excision repair pathway By blocking PARP activity rucaparib impairs DNA repair especially in cells with pre-existing DNA repair deficiencies such as those induced by genotoxic stress In prostate cancer research rucaparib induces radiosensitization notably in PTEN-deficient cells expressing ETS fusion proteins through inhibition of non-homologous end joining (NHEJ) It is thus relevant in studies investigating DNA damage response pathways cancer biology and therapeutic radiosensitization strategies
Apexbio Technology LLC Alagebrium chloride 341028-37-3 200mg
Alagebrium chloride (CAS 341028-37-3) is a small molecule inhibitor that targets advanced glycation end-products (AGEs) by cleaving pre-existing AGE-derived protein cross-links AGEs are formed through non-enzymatic reactions between reducing sugars and proteins or lipids progressively accumulating with age and contributing to tissue stiffening and functional decline By disrupting AGE-mediated cross-linking alagebrium chloride has been studied for its potential to restore tissue elasticity and improve organ function This compound is utilized in research investigating age-related pathological processes and therapeutic strategies for diseases associated with elevated AGE accumulation
Medchemexpress LLC RU.521 | 25MG
RU 521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation RU 521 suppresses dsDNA-activated reporter activity with an IC50 of 0 7 M RU 521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Gouti res syndrome (AGS)[1]
TARGETMOL CHEMICALS INC Repaglinide 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically apparent acute liver injury. Purity 99.66%
Medchemexpress LLC Madecassoside | 34540-22-2 | 975.12 | 200 MG
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica with anti-inflammatory, antioxidant, and anti-aging properties. It is orally active and inhibits inflammation, oxidation, apoptosis, and autophagy by inhibiting p38 MAPK and NF-κB activities, exhibiting anti-apoptotic properties, and activating Nrf2 expression. It has potential applications in endocrine, cardiovascular, and skin diseases.
- Isolated from Centella asiatica.
- Anti-inflammatory, antioxidant, and anti-aging effects.
- Orally active.
- Inhibits inflammation, oxidation, apoptosis, and autophagy.
- Inhibits p38 MAPK and NF-κB activities.
- Exhibits anti-apoptotic properties.
- Activates Nrf2 expression to reduce neurotoxicity.
- Potential for endocrine, cardiovascular, and skin diseases.
Medchemexpress LLC Endothelin-1 (1-31) (Human) | 133972-52-8 | 99.7% | 3628.16 | 1 MG
Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent derived from the selective hydrolysis of big ET-1 by chymase. In vitro, it induces human mesangial cell proliferation and ERK activation. In vivo, it induces contraction in the mouse mesenteric artery, possibly mediated by the ETA receptor. This contraction can be increased by aging, and gender differences have been observed in chronic diabetic conditions.
- Potent vasoconstrictor.
- Hypertensive agent.
- Derived from selective hydrolysis of big ET-1 by chymase.
- Induces human mesangial cell proliferation and ERK activation in vitro.
- Induces contraction in mouse mesenteric artery in vivo.
- Possible ETA receptor mediation.
- Effects can be increased by aging.
- Gender differences observed in chronic diabetic conditions.
Apexbio Technology LLC Meclofenoxate hydrochloride 3685-84-5 200mg
Meclofenoxate hydrochloride (CAS 3685-84-5) is a synthetic compound formed from dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA) It is understood to influence cholinergic neurotransmission likely by increasing acetylcholine levels in the central nervous system through metabolic conversion of DMAE Preclinical studies have demonstrated that meclofenoxate hydrochloride enhances memory retention and supports various aspects of cognitive function This molecule is widely utilized in neurological and cognitive research to explore mechanisms underlying neuroprotection memory enhancement and age-related cognitive decline
Medchemexpress LLC RU-521 | 2262452-06-0 | 100.0% | 415.23 | 50 MG
RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor. It inhibits cGAS-mediated interferon upregulation and suppresses dsDNA-activated reporter activity.
- Inhibits cGAS-mediated interferon upregulation.
- Suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM.
- Reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).
- Reduces symptoms from sepsis in mice, increasing cardiac function and decreasing inflammatory responses.
Medchemexpress LLC Scopoletin | 92-61-5 | MFCD00006872 | 99.9% | 192.17 | 200 MG
Scopoletin is an inhibitor of acetylcholinesterase (AChE). This compound is used in research to study its effects on cellular processes, including proliferation and apoptosis in various cell lines, and its impact on cognitive functions in animal models.
- Enhances K+-stimulated release of ACh from rat frontal cortex synaptosomes.
- Inhibits PC3 proliferation by inducing apoptosis of PC3 cells.
- Increases T-maze alternation and ameliorates scopolamine-induced cholinergic deficit and age-associated deficits in object memory in mice.
- Available as solid or solution formulations in various quantities.
- For research use only.
Medchemexpress LLC Verteporfin | 129497-78-5 | 98.2% | 200 MG
Verteporfin (CL 318952) is a photosensitizer used in photodynamic therapy to eliminate abnormal blood vessels in the eye, especially those associated with age-related macular degeneration. It functions as a YAP inhibitor by disrupting YAP-TEAD interactions, inducing cell apoptosis. This compound also acts as an autophagy inhibitor, blocking autophagosome formation at an early stage.
- Acts as a YAP inhibitor, disrupting YAP-TEAD interactions.
- Induces cell apoptosis.
- Inhibits autophagy by blocking autophagosome formation at an early stage.
- Utilized as a photosensitizer for photodynamic therapy.
- Shows light-independent anti-leukemic activity.
- Reduces mitochondrial membrane potential in PDX cells.
- Reverses certain drug resistances by inhibiting YAP expression.
Medchemexpress LLC Thioridazine | 50-52-2 | MFCD00242875 | 99.5% | 200 MG
Thioridazine is an antagonist of the dopamine receptor D2 family proteins, exhibiting potent anti-psychotic and anti-anxiety activities. It is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with an anti-angiogenic effect, showing antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity in targeting cancer stem cells (CSCs).
- Reduces cell viability of NCI-N87 and AGS cells
- Reduces cell viability of cervical and endometrial cancer cells
- Induces gastric cancer cell death via the mitochondrial apoptosis pathway
- Modulates cell cycle progression by interfering with the PI3K/Akt pathway and induces G1 cell cycle arrest
- Inhibits the growth of antibiotic-sensitive and multidrug-resistant strains of A. baumannii
- Extends the survival of tumor-bearing mice
- Reduces oral behavior and selectively blocks repetitive head bobbing