Quinolines and derivatives
Apexbio Technology LLC Rucaparib (AG-014699,PF-01367338) 459868-92-9 200mg
Rucaparib (AG-014699 PF-01367338 CAS 459868-92-9) is a small molecule inhibitor targeting poly(ADP-ribose) polymerase (PARP) a nuclear enzyme activated by DNA damage and central to the base excision repair pathway By blocking PARP activity rucaparib impairs DNA repair especially in cells with pre-existing DNA repair deficiencies such as those induced by genotoxic stress In prostate cancer research rucaparib induces radiosensitization notably in PTEN-deficient cells expressing ETS fusion proteins through inhibition of non-homologous end joining (NHEJ) It is thus relevant in studies investigating DNA damage response pathways cancer biology and therapeutic radiosensitization strategies
Apexbio Technology LLC Alagebrium chloride 341028-37-3 200mg
Alagebrium chloride (CAS 341028-37-3) is a small molecule inhibitor that targets advanced glycation end-products (AGEs) by cleaving pre-existing AGE-derived protein cross-links AGEs are formed through non-enzymatic reactions between reducing sugars and proteins or lipids progressively accumulating with age and contributing to tissue stiffening and functional decline By disrupting AGE-mediated cross-linking alagebrium chloride has been studied for its potential to restore tissue elasticity and improve organ function This compound is utilized in research investigating age-related pathological processes and therapeutic strategies for diseases associated with elevated AGE accumulation
Medchemexpress LLC RU.521 | 25MG
RU 521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation RU 521 suppresses dsDNA-activated reporter activity with an IC50 of 0 7 M RU 521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Gouti res syndrome (AGS)[1]
TARGETMOL CHEMICALS INC Repaglinide 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically apparent acute liver injury. Purity 99.66%
Apexbio Technology LLC Meclofenoxate hydrochloride 3685-84-5 200mg
Meclofenoxate hydrochloride (CAS 3685-84-5) is a synthetic compound formed from dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA) It is understood to influence cholinergic neurotransmission likely by increasing acetylcholine levels in the central nervous system through metabolic conversion of DMAE Preclinical studies have demonstrated that meclofenoxate hydrochloride enhances memory retention and supports various aspects of cognitive function This molecule is widely utilized in neurological and cognitive research to explore mechanisms underlying neuroprotection memory enhancement and age-related cognitive decline