Tetrahydroisoquinolines
Sigma Aldrich Tetrahydro-2-(2-propynyloxy)-2H-pyran
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 1,5-Dihydroxy-1,2,3,4-tetrahydronaphthalene
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 2,3-Dimethylindole
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 1,2,3,4-Tetrahydroisoquinoline
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Medchemexpress LLC SR10067 | 1380548-02-6 | 99.2% | 465.58 g·mol⁻1 | C31H31NO3 | 25 MG
SR10067 is a potent, selective, brain-penetrant REV-ERB agonist used as a research tool to study circadian biology, metabolic regulation, and neuropsychiatric disorders. It has reported IC50 values of approximately 160-170 nM and a molecular weight of 465.58 g·mol⁻1.
- Potent, selective REV-ERB agonist with low-nanomolar activity.
- Brain-penetrant small molecule suitable for in vivo studies.
- High chemical purity (≈99.2% by supplier analysis).
- Molecular formula C31H31NO3 and molecular weight 465.58 g·mol⁻1.
- Stable as powder at -20°C for long-term storage.
- Suitable for receptor assays, cell-based studies, and in vivo pharmacology.
Medchemexpress LLC Ecteinascidin 770 | 114899-80-8 | 99.8% | 770.85 g/mol | C40H42N4O10S | 5 MG
Ecteinascidin 770 (ET-770) is a tetrahydroisoquinoline alkaloid research compound with potent anticancer activity. It is supplied as a solid (white to yellow) and as a DMSO solution for laboratory use; intended for in vitro research and should be handled according to supplier documentation and SDS guidance.
- Potent anticancer activity; IC50 4.83 nM against U373MG cells.
- High purity typically around 99.8%.
- Molecular formula C40H42N4O10S and molecular weight 770.85 g/mol.
- Available in small-scale solid pack sizes and as a 10 mM solution in DMSO.
- Solid appearance: white to yellow powder; soluble in DMSO for assays.
Medchemexpress LLC Ys-370 | 2470908-79-1 | MFCD34676892 | 98.1% | 663.60 g/mol | C37H35BrN4O3 | 5 MG
YS-370 is a small-molecule P-glycoprotein (P-gp) inhibitor for research use. It is a white to off-white solid (CAS 2470908-79-1) with molecular formula C37H35BrN4O3 and molecular weight 663.60 g/mol, intended for in vitro and preclinical P-gp inhibition studies.
- High purity, 98.1% (reported by HPLC).
- Solid form, white to off-white, stable for storage.
- Available in small pack sizes for screening, 5 mg to 100 mg.
- Suitable for in vitro and in vivo P-gp inhibition assays.
- Analytical data available: COA, H NMR, LC-MS.
Medchemexpress LLC Ecteinascidin 770 | 114899-80-8 | 99.8% | 770.85 g/mol | C40H42N4O10S | 10 MG
Ecteinascidin 770 is a 1,2,3,4-tetrahydroisoquinoline alkaloid natural product used in preclinical cancer research for its potent cytotoxic and apoptosis-inducing activities. It is typically handled as a solid and prepared in solvent for in vitro assays, showing low-nanomolar inhibitory potency across several human tumor cell lines.
- Induces apoptosis in tumor cell lines.
- Exhibits low-nanomolar potency (reported IC50 values in multiple lines).
- Molecular formula C40H42N4O10S and molecular weight ~770.85 g/mol.
- Soluble in DMSO for biological testing.
- Supplied as a small solid vial suitable for research use.
Medchemexpress LLC Encequidar mesylate | 849675-87-2 | MFCD25976626 | 99.8% | 784.8 g/mol | C39H40N6O10S | 5 MG
Encequidar mesylate is the mesylate salt of encequidar, a potent, competitive inhibitor of P-glycoprotein (P-gp/ABCB1) used as a research tool to probe transporter-mediated drug disposition, oral bioavailability, and drug-drug interactions. It is provided as a high-purity solid suitable for in vitro and in vivo studies.
- Potent competitive inhibitor of P-glycoprotein for transporter studies.
- High reported purity (99.82%), suitable for analytical and biological work.
- Available in small pre-weighed quantities for dosing and assay use.
- Provides molecular formula and molecular weight for formulation and calculation.
- Supplied as a mesylate salt to improve stability and handling.
Medchemexpress LLC Ecteinascidin 770 | 114899-80-8 | 99.8% | 770.85 | C40H42N4O10S | 50 MG
Ecteinascidin 770 is a tetrahydroisoquinoline alkaloid with potent cytotoxic and anticancer activity. It shows low-nanomolar IC50 values across multiple human cancer cell lines and is intended for preclinical in vitro research. The compound is provided as a high-purity solid or as a DMSO solution and is documented with CAS 114899-80-8, formula C40H42N4O10S, and molecular weight 770.85.
- High purity (≈99.8%).
- Potent cytotoxic activity with low-nanomolar IC50 in multiple human cancer cell lines.
- Suitable for in vitro and preclinical research applications.
- Available in mg-scale quantities and as DMSO solutions.
- Characterized by CAS 114899-80-8, formula C40H42N4O10S, molecular weight 770.85.
Medchemexpress LLC TCS-OX2-29 | 372523-75-6 | 99.6% | 397.51 g/mol | C23H31N3O3 | 25 MG
TCS-OX2-29 is a potent, selective orexin-2 receptor (OX2R) antagonist used in neuropharmacology research to probe orexin signaling and sleep-wake regulation. Reported activity includes an IC50 of 40 nM and a pKi of 7.5, with approximately 250-fold selectivity for OX2 over OX1. The compound is supplied as a high-purity solid and is available in DMSO solution formats for easy reconstitution.
- Potent OX2R antagonist with IC50 ≈ 40 nM.
- High selectivity for OX2 over OX1 (~250-fold).
- High purity suitable for research applications (≈99.6%).
- Available as a solid and as 10 mM DMSO solution for reconstitution.
- Molecular weight 397.51 g/mol; molecular formula C23H31N3O3.
Medchemexpress LLC 1(2H)-isoquinolinone, 5-hydroxy- | 5154-02-9 | MFCD00006900 | 99.1% | 161.16 g·mol⁻¹ | C9H7NO2 | 1 ML
1,5-Isoquinolinediol is a small-molecule poly(ADP-ribose) polymerase (PARP) inhibitor (CAS 5154-02-9) used in biochemical research. It exhibits in vitro potency with reported IC50 values of 0.18-0.37 μM and is employed to study PARP-mediated oxidative stress, including diabetes-induced NADPH oxidase-derived retinal damage.
- High purity suitable for research applications.
- Reported IC50 0.18-0.37 μM against PARP.
- Molecular formula C9H7NO2; molecular weight 161.16 g·mol⁻¹.
- Available as solid and as a 10 mM solution in DMSO.
- Used to study PARP-related oxidative stress and retinal models.
- Supplied with a certificate of analysis for batch-specific quality.
Medchemexpress LLC D-tetrahydropalmatine | 3520-14-7 | MFCD11046348 | 99.8% | 355.43 | C21H25NO4 | 10 MG
D-Tetrahydropalmatine is an isoquinoline alkaloid research reagent that acts as a dopamine receptor antagonist with preferential affinity for D1 receptors and reported inhibition of organic cation transporter 1 (OCT1). It is supplied as a solid for pharmacological and biochemical studies of dopamine signaling.
- CAS number: 3520-14-7.
- Molecular formula: C21H25NO4.
- Molecular weight: 355.43.
- Purity: 99.8%.
- Appearance: white to light yellow solid.
- Solubility: 50 mg/mL in DMSO (≈140.67 mM).
- Storage: powder at -20°C for up to 3 years; in solution at -80°C for extended storage.
- Intended use: for research only, not for diagnostic or therapeutic applications.
Medchemexpress LLC Cephaeline dihydrochloride | 5853-29-2 | MFCD01732155 | 99.0% | 539.53 | C28H40Cl2N2O4 | 10 MG
Cephaeline dihydrochloride is the dihydrochloride salt of cephaeline, a small-molecule research reagent that acts as a selective inhibitor of cytochrome P450 2D6. It is supplied as a solid, white to off-white powder with high purity and solubility properties suitable for in vitro and selected in vivo formulations.
- Selective CYP2D6 inhibitor with reported IC50 of 121 μM.
- High purity suitable for research use (≈99%).
- Molecular formula C28H40Cl2N2O4; molecular weight 539.53.
- Solid, white to off-white appearance.
- Soluble in DMSO and water; demonstrated in defined in vivo formulations.
- Recommended storage sealed, away from moisture and light; long-term storage in solvent at -80°C.
- Common applications include enzyme inhibition assays and pharmacology studies.
Medchemexpress LLC SR10067 | 1380548-02-6 | 99.2% | 465.58 | C31H31NO3 | 50 MG
SR10067 is a potent, selective, brain-penetrant REV-ERBα/β agonist used in preclinical research on circadian regulation, metabolic and neuropsychiatric disorders. Reported IC50 values are approximately 160 nM (Rev-Erbβ) and 170 nM (Rev-Erbα).
- Potent REV-ERB agonist with low-nanomolar activity.
- Brain-penetrant small molecule suitable for in vivo studies.
- High purity (≈99.2%) suitable for research applications.
- Molecular weight 465.58 and formula C31H31NO3.
- Solid, white to off-white appearance; storage guidelines provided by supplier.
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