The TL1A protein (VEGI protein) belongs to the tumor necrosis factor (TNF) family and is a receptor for TNFRSF25 and TNFRSF6B TL1A is involved in the activation of NF- B and C-Jun pathways which can be used as a regulator of mucosal immunity and participate in the immune pathway of inflammatory bowel disease (IBD) pathogenesis[1][2] TL1A originates from endothelial cells and inhibits the proliferation of breast cancer epithelial and myeloid tumor cells[3] The human TL1A protein has a transmembrane domain (36-56 a a ) that can be cleaved into membrane-type and soluble peptide fragments TL1A/TNFSF15 Trimer Protein Human (HEK293 His-Flag) is the extracullar part of TL1A protein (D91-L251) produced in HEK293 cells with N-terminal His- and Flag-tag