Carboximidamides
Apexbio Technology LLC CLONIDINE-100MG
Clonidine (CAS No 4205-90-7) is a pharmacologically active compound primarily researched within the neuroscience and pharmacology fields Originating as an antihypertensive agent its mechanism mainly involves acting as an agonist at the alpha-2 adrenergic receptors in the central nervous system leading to reduced sympathetic outflow and decreased blood pressure Clonidine exhibits potent activity in the nanomolar to low micromolar range in vitro demonstrating a strong affinity for its target receptors It is commonly used in various experimental applications including cell models to study receptor interactions and animal models to evaluate effects on hypertension pain and withdrawal symptoms In drug screening clonidine serves as a reference compound particularly in investigations of novel treatments for disorders like ADHD and anxiety Experimental concentrations typically depend on the specific research design
Medchemexpress LLC Glycyrrhisoflavone | 116709-70-7 | 5 MG
Glycyrrhisoflavone, an active prenylflavonoid, inhibits α-glucosidase. It is intended for research use only.
- Active prenylflavonoid
- Inhibits α-glucosidase
- For research use only
- Purity of 99.43%
- Appearance is off-white to light yellow solid
- Classified as a flavonoid, isoflavone, phenol, polyphenol
- Derived from Glycyrrhiza uralensis Fisch.
- Shows cytotoxicity against human PC3 cells (IC50 62.1 μM)
- Shows cytotoxicity against african green monkey Vero cells (IC50 52.8 μM)
eMolecules 50-01-1 | Guanidine hydrochloride | Chem-Impex | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 250g | 322126115
Guanidine hydrochloride | Chem-Impex | 50-01-1 | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 250g | 322126115
Medchemexpress LLC Auda | 479413-70-2 | 98.0% | 392.58 | 1 ML
AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor. It exhibits anti-inflammatory activity, making it suitable for various research applications.
- Potent soluble epoxide hydrolase (sEH) inhibitor
- Exhibits anti-inflammatory activity
- Suitable for research applications
Medchemexpress LLC Melagatran | 159776-70-2 | 99.3% | 429.51 g·mol⁻¹ | C22H31N5O4 | 5 MG
Melagatran is a reversible, selective, orally active small-molecule direct inhibitor of thrombin for preclinical research. It binds the thrombin active site (Ki ≈ 2 nM), blocking thrombin-mediated conversion of fibrinogen to fibrin and modulating NF-κB and AP-1 pathways. Typical research applications include thrombosis, atherosclerosis, and ischemic brain injury models.
- Direct and potent thrombin inhibition with low nanomolar Ki.
- Suitable for in vitro and in vivo cardiovascular research.
- High reported purity (~99.3%) for reliable results.
- Solid powder form facilitating storage and handling.
- Storage recommendations: powder at -20°C; solutions at -80°C for long-term storage.
Medchemexpress LLC PDE12-IN-1 | 2259620-80-7 | 98.9% | 616.48 | C31H27BrFN5O3 | 10 MG
PDE12-IN-1 is a selective phosphodiesterase 12 (PDE12) inhibitor provided for laboratory research use. It shows potent enzyme inhibition and modulates 2′,5′-linked adenylate polymer levels in cellular assays. Intended for in vitro biochemical and cell-based studies; not for human or clinical use.
- Selective PDE12 inhibition with reported pIC50 ≈ 9.1.
- Suitable for biochemical and cellular assays.
- High purity: 98.9%.
- Available in small pack sizes for screening and optimization.
- Molecular formula C31H27BrFN5O3; molecular weight 616.48.
Medchemexpress LLC 5-Ureidohydantoin (Standard) | 97-59-6 | MFCD00005260 | 158.12 | 50 MG
Allantoin (Standard) is the analytical standard of Allantoin. It is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth. This product is intended for research and analytical applications. The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
- Analytical standard for research and analytical applications.
- Promotes healthy skin.
- Stimulates new and healthy tissue growth.
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
Medchemexpress LLC Allantoin (5-Ureidohydantoin) | 97-59-6 | 98.9% | 158.12 | 100 MG
Allantoin is a skin conditioning agent that promotes healthy skin and stimulates new and healthy tissue growth. It possesses anti-oxidative and anti-inflammatory activities and can ameliorate chemically-induced pancreatic β-cell damage.
- Promotes healthy skin and stimulates new tissue growth
- Exhibits anti-oxidative and anti-inflammatory activities
- Attenuates apoptosis and cytotoxicity, increasing β-cell viability
- Activates imidazoline 3 (I3) receptors
- Increases neuronal cell proliferation in the hippocampal dentate gyrus region
- Lowers plasma glucose and increases plasma insulin levels
- Decreases blood pressure
Medchemexpress LLC Smap-2 (DT-1154) | 1809068-70-9 | 99.5% | 5 MG
SMAP-2 (DT-1154) is a small-molecule, orally active activator of protein phosphatase 2A (PP2A) with demonstrated anti-cancer activity in preclinical studies. It is supplied as a white to off-white solid and includes manufacturer-reported solubility and storage guidance.
- Orally bioavailable PP2A activator with anticancer activity.
- High purity: 99.53% (manufacturer reported).
- Molecular weight 532.57; formula C27H27F3N2O4S.
- Soluble in DMSO (300 mg/mL); in vivo formulation guidance provided.
- Powder storage: -20°C (3 years) or 4°C (2 years); in solvent: -80°C (2 years).
Medchemexpress LLC Siguazodan | 115344-47-3 | 99.1% | 10 MG
Siguazodan is a selective phosphodiesterase 3 (PDE3) inhibitor supplied as a high-purity research reagent. It increases intracellular cAMP, exhibits anti-platelet and vasodilatory activity in preclinical studies, and is provided as a solid suitable for laboratory use.
- Potent and selective PDE3 inhibitor.
- High purity (99.1%).
- Provided as a 10 MG solid for laboratory use.
- Demonstrated anti-platelet and vasodilatory effects in preclinical studies.
- Intended for research and analytical applications only.
Medchemexpress LLC AUDA | 479413-70-2 | 98.0% | 392.58 | 100 MG
AUDA is a potent soluble epoxide hydrolase (sEH) inhibitor that exhibits anti-inflammatory activity. It is effective against both mouse and human sEH, with IC50 values of 18 nM and 69 nM respectively.
- Potent soluble epoxide hydrolase (sEH) inhibitor
- Exhibits anti-inflammatory activity
- Suppresses the proliferation of rat VSMCs
- Upregulates COX-2 expression
- Augments the migratory ability of HCAECs
- Increases the adhesion ability of HCAECs
- Reduces TNF-α, MMP-9, and IL-1β expression levels
(F)(F)(F)F.CN(C)C(Cl)=[N+](C)C | 100g | 480127736](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000158643.jpg-250.jpg)
eMolecules 94790-35-9 | Chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate | Oakwood Chemicals | MFCD01862891 | 280.580 | C5H12ClF6N2P | 95.000 | F[P-](F)(F)(F)(F)F.CN(C)C(Cl)=[N+](C)C | 100g | 480127736
Chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate | Oakwood Chemicals | 94790-35-9 | MFCD01862891 | 280.580 | C5H12ClF6N2P | 95.000 | F[P-](F)(F)(F)(F)F.CN(C)C(Cl)=[N+](C)C | 100g | 480127736