Enamines
Nifedipine, 98%
CAS: 21829-25-4 Molecular Formula: C17H18N2O6 Molecular Weight (g/mol): 346.34 MDL Number: MFCD00057326 InChI Key: HYIMSNHJOBLJNT-UHFFFAOYSA-N Synonym: nifedipine,procardia,adalat,procardia xl,adalat cc,cordipin,corinfar,fenihidine,citilat,oxcord PubChem CID: 4485 ChEBI: CHEBI:7565 IUPAC Name: 3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate SMILES: COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1[N+]([O-])=O)C(=O)OC
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.66 g·mol⁻¹ | C27H26F3N7O6S2 | 25 MG
PF-562271 besylate is a small-molecule, ATP-competitive and reversible inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2). It exhibits low-nanomolar potency in biochemical assays and is used in biochemical and cell-based studies to investigate FAK/Pyk2 signaling, cell migration, and cancer-related pathways. Supplied as a high-purity solid for research use.
- Potent ATP-competitive, reversible inhibition of FAK and Pyk2.
- Low-nanomolar biochemical potency (FAK IC50 ≈ 1.5 nM; Pyk2 IC50 ≈ 13 nM).
- Suitable for biochemical and cell-based assays investigating signaling and migration.
- High purity appropriate for research applications.
- Soluble in DMSO and largely insoluble in water.
- Available in small research pack sizes for laboratory studies.
Medchemexpress LLC Molibresib besylate | 1895049-20-3 | 97.0% | 1 ML
Molibresib besylate is an orally active pan-BET inhibitor that targets and binds to BRD2, BRD3, BRD4, and BRDT. It competitively occupies acetylated lysine binding sites, disrupting the interaction between BET proteins and chromatin. This action inhibits MYC expression and target gene transcription, demonstrating broad antiproliferative activity by inhibiting cancer cell growth and inducing growth arrest.
- Inhibits cancer cell proliferation and induces cell cycle arrest.
- Downregulates mitosis-related genes and upregulates p-ERK1/2.
- Shows synergistic anti-proliferative effects with MEK inhibitors.
- Reduces tumor burden and prolongs survival in mouse models of leukemia.
- Applicable to research in acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, and other advanced solid tumors.
Medchemexpress LLC Molibresib (besylate) | 1895049-20-3 | 97.0% | 50 MG
Molibresib besylate is an orally active pan-BET inhibitor that targets BRD2, BRD3, BRD4, and BRDT. It disrupts the interaction between BET proteins and chromatin, inhibiting MYC expression and target gene transcription. This compound exhibits broad antiproliferative activity, inhibiting cancer cell growth and inducing growth arrest. It is widely applicable to research related to acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, small-cell lung cancer, and various advanced refractory solid tumors.
- Orally active pan-BET inhibitor.
- Targets BRD2, BRD3, BRD4, and BRDT.
- Inhibits MYC expression and target gene transcription.
- Exhibits broad antiproliferative activity.
- Shows synergistic effect with MEK inhibitors.
- Applicable for research in acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, and small-cell lung cancer.
Apexbio Technology LLC AMLODIPINE-MALEATE-1G
Amlodipine maleate (CAS No 88150-47-4) is a calcium channel blocker commonly used in cardiovascular research Originating from the dihydropyridine class its mechanism of action involves inhibiting the influx of calcium ions through L-type calcium channels leading to vasodilation and reduced blood pressure This compound has demonstrated in vitro activity in the nanomolar to low micromolar range making it a valuable tool for studying cardiac function and vascular smooth muscle relaxation It is often utilized in cell models including cardiomyocytes and endothelial cells as well as in animal studies to explore hypertension and related pathologies Additionally amlodipine maleate is employed in high-throughput drug screening assays to identify potential therapeutic agents Experimental concentrations typically depend on the specific research design
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.66 g/mol | C27H26F3N7O6S2 | 1 ML
PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 used in biochemical, cell-based, and in vivo research. It is supplied as a 10 mM solution in DMSO and exhibits low-nanomolar activity against FAK and nanomolar activity against Pyk2.
- Potent inhibition of FAK and Pyk2 (FAK IC50 = 1.5 nM; Pyk2 IC50 = 13 nM).
- Supplied as a ready-to-use 10 mM solution in DMSO for in vitro assays.
- High reported purity suitable for research use (99.17%).
- Demonstrated antiproliferative activity across multiple cancer cell lines.
- Validated pharmacological effects in vivo, including inhibition of FAK phosphorylation.
Apexbio Technology LLC AMLODIPINE-MALEATE-500MG
Amlodipine maleate (CAS No 88150-47-4) is a calcium channel blocker commonly used in cardiovascular research Originating from the dihydropyridine class its mechanism of action involves inhibiting the influx of calcium ions through L-type calcium channels leading to vasodilation and reduced blood pressure This compound has demonstrated in vitro activity in the nanomolar to low micromolar range making it a valuable tool for studying cardiac function and vascular smooth muscle relaxation It is often utilized in cell models including cardiomyocytes and endothelial cells as well as in animal studies to explore hypertension and related pathologies Additionally amlodipine maleate is employed in high-throughput drug screening assays to identify potential therapeutic agents Experimental concentrations typically depend on the specific research design
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.66 | C27H26F3N7O6S2 | 10 MG
PF-562271 besylate is the besylate salt of PF-562271, a potent ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 used in cancer research to probe signaling pathways, tumor growth, and cell adhesion. The compound is supplied as a high-purity solid for in vitro and in vivo studies.
- Potent inhibition of FAK and Pyk2 (FAK IC50 ~1.5 nM; Pyk2 IC50 ~13 nM).
- High reported purity (99.17%).
- Provided as a solid, off-white to light-yellow material suitable for handling and formulation.
- Demonstrated antiproliferative activity in multiple human cell lines.
- Used for in vitro and in vivo studies of tumor growth, signaling, and angiogenesis.
- Available in a 10 mg package for research use.
Apexbio Technology LLC Cisatracurium Besylate 96946-42-8 100mg
Cisatracurium Besylate (CAS 96946-42-8) is a non-depolarizing neuromuscular blocking agent that acts by competitively inhibiting acetylcholine at nicotinic receptors on the neuromuscular junction This inhibition prevents depolarization of the muscle cell membrane resulting in skeletal muscle relaxation Cisatracurium Besylate is utilized in biomedical research to study neuromuscular transmission skeletal muscle function and mechanisms underlying muscle paralysis It is also frequently used as an adjunct in anesthesia research to model conditions requiring controlled muscle relaxation such as intubation or mechanical ventilation
Apexbio Technology LLC Cisatracurium Besylate 96946-42-8 25mg
Cisatracurium Besylate (CAS 96946-42-8) is a non-depolarizing neuromuscular blocking agent that acts by competitively inhibiting acetylcholine at nicotinic receptors on the neuromuscular junction This inhibition prevents depolarization of the muscle cell membrane resulting in skeletal muscle relaxation Cisatracurium Besylate is utilized in biomedical research to study neuromuscular transmission skeletal muscle function and mechanisms underlying muscle paralysis It is also frequently used as an adjunct in anesthesia research to model conditions requiring controlled muscle relaxation such as intubation or mechanical ventilation
Apexbio Technology LLC Cisatracurium Besylate 96946-42-8 10mM (in 1mL DMSO)
Cisatracurium Besylate (CAS 96946-42-8) is a non-depolarizing neuromuscular blocking agent that acts by competitively inhibiting acetylcholine at nicotinic receptors on the neuromuscular junction This inhibition prevents depolarization of the muscle cell membrane resulting in skeletal muscle relaxation Cisatracurium Besylate is utilized in biomedical research to study neuromuscular transmission skeletal muscle function and mechanisms underlying muscle paralysis It is also frequently used as an adjunct in anesthesia research to model conditions requiring controlled muscle relaxation such as intubation or mechanical ventilation
Medchemexpress LLC CDK2-IN-4 | 1316652-41-1 | 99.3% | 326.37 g/mol | C16H14N4O2S | 5 MG
NCC-149 is a selective histone deacetylase 8 (HDAC8) inhibitor used in cell biology research, including studies of neural differentiation. The product is provided with supporting documentation for purity, handling, and storage, and is available both as a solid and as a DMSO solution.
- Selective HDAC8 inhibitor for neural differentiation studies.
- Documented purity approximately 99.3% based on certificate of analysis.
- Available as a solid and as a 10 mM solution in DMSO.
- Datasheet, certificate of analysis, and safety data sheet provided for quality and safety information.
- Storage recommendations included for powdered material and solutions.
Apexbio Technology LLC Amlodipine Besylate 111470-99-6 10mM (in 1mL DMSO)
Amlodipine Besylate (CAS 111470-99-6) is a long-acting calcium channel blocker that reduces blood pressure primarily through inhibition of calcium ion influx via voltage-gated calcium channels Calcium channel modulation influences critical cellular signaling pathways In cortical neurons exposed to oxidative stress Amlodipine Besylate ( 5 M) preserves cellular viability by reducing oxidative damage enhancing pro-survival signals and suppressing apoptotic pathways It has also demonstrated proliferative effects on human epidermoid carcinoma (A431) cells Furthermore clinical studies indicate that Amlodipine Besylate decreases peripheral vascular resistance and myocardial oxygen demand in angina patients and effectively lowers arterial pressure in hypertensive feline models
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.7 g/mol | C27H26F3N7O6S2 | 1 MG
PF-562271 besylate is an ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) used as a research tool in cell-signaling and oncology studies. It exhibits potent biochemical activity (FAK IC50 ≈ 1.5 nM; Pyk2 IC50 ≈ 13-14 nM), is supplied as the besylate salt, and is available at high purity for in vitro and in vivo research.
- Potent ATP-competitive, reversible inhibitor of FAK and Pyk2.
- Low nanomolar biochemical potency for target kinases.
- Provided as a besylate salt for improved stability and handling.
- High reported purity suitable for research applications.
- Used in cellular and animal model studies of tumor signaling pathways.
Medchemexpress LLC Molibresib besylate | 1895049-20-3 | 97.0% | 100 MG
Molibresib besylate is an orally active pan-BET inhibitor. It targets BRD2, BRD3, BRD4, and BRDT, disrupting their interaction with chromatin by occupying acetylated lysine binding sites. This inhibits MYC expression and target gene transcription. It exhibits broad antiproliferative activity, useful for research in acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, small-cell lung cancer, and other advanced refractory solid tumors.
- Disrupts BET protein-chromatin interaction
- Inhibits MYC expression and target gene transcription
- Exhibits broad antiproliferative activity
- Induces growth arrest and downregulates mitosis-related genes
- Upregulates p-ERK1/2 levels
- Shows synergistic effects with MEK inhibitors
- Modulates immune microenvironment and prolongs survival in models