Sulfoxides
Medchemexpress LLC Elafibranor sulfoxide | 95.0% | 400.49 | 25 MG
Elafibranor (GFT505) sulfoxide is a sulfoxide metabolite of Elafibranor (HY-16737). Elafibranor is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively. Elafibranor can be used for the study of primary biliary cholangitis.
- Purity: 95.0%
- Molecular weight: 400.49
- Formula: C22H24O5S
- Appearance: Solid
- Color: Light yellow to yellow
- Solubility (in vitro): 100 mg/mL (DMSO)
- Storage (powder): -20°C 3 years, 4°C 2 years
- Storage (in solvent): -80°C 6 months, -20°C 1 month
- Research use only
Medchemexpress LLC Cytochrome P450 3A4 Antibody (YA3715) | 10 UL
The CYP3A4 protein, a cytochrome P450 monooxygenase, is intricately involved in the metabolism of a diverse array of substrates, including sterols, steroid hormones, retinoids, and fatty acids. It plays a crucial role in various biological processes such as androgen and cholesterol metabolism, retinoid metabolism, and the oxidative metabolism of xenobiotics, acting as a major contributor to drug metabolism. This antibody also contributes to vitamin D catabolism and calcium homeostasis.
- Mouse-derived and non-conjugated IgG1 monoclonal antibody
- Targets Cytochrome P450 3A4
- Reactivity: Human, mouse, rat
- Formulated in PBS, pH 7.4
- Store at -20°C for 1 year
- Avoid repeated freeze / thaw cycles
- Liquid appearance
- Suitable for WB, IHC-P, ICC/IF, FC, ELISA applications
Cayman Chemical Sulforaphane Inhibitors
An isothiocyanate that potently induces chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression; at 15 μM, inhibits class I and II HDAC activity and suppresses tumor growth selectively in cancerous prostate epithelial cells without affecting normal cells
Medchemexpress LLC MRGPRX2 modulator-1 | 2781839-42-5 | 99.03% | 459.39 | 5 MG
MRGPRX2 modulator-1 (example 17) is a mas-related g-protein receptor x2 (MRGPRX2) modulator. It can be used for the research of inflammation, pain, and autoimmune disorders.
- Research Reagent: For research use only.
- High Purity: 99.03%.
- Versatile Application: Useful for studying inflammation, pain, and autoimmune disorders.
- Multiple Formats: Available as solid or in DMSO solution.
Cayman Chemical SulIndac sulfon 10mg
An oxidized metabolite of sulindac that is produced in many mammals but minimally in mice and rats; generally considered to be inactive against COX enzymes, although it can reduce azoxymethane-induced colon cancer in rats; inhibits aldose reductase (IC50 = 367 nM) in vitro
Cayman Chemical Sulindac sulfide
An active metabolite of sulindac; inhibits COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications; inhibits colorectal cancer growth in vitro and in vivo
Medchemexpress LLC 3-isoxazolecarboxamide, N-(2-cyclohexyl-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazol-4-yl)-4-methyl-5-... | 1825371-51-4 | 99.8% | 446.54 | 1 MG
Smurf1 modulator-1 (Compound 20) is a selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1), with an IC50 of 180 nM. This product is for research use only and not sold to patients.
- Selective inhibitor for Smad ubiquiquitination regulatory factor 1 (Smurf1).
- IC50 of 180 nM.
- For research use only.
- Appearance is a white to off-white solid.
- Specific storage conditions for powder and in solvent.
- Soluble in DMSO.