Sulfoxides
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | C22H31NO2 | 25 MG
CB2R/FAAH modulator-3 is a dual-targeting modulator that acts as a CB2R agonist and FAAH inhibitor. It has potential applications in studies related to cancer, neurodegenerative diseases, and COVID-19 infection.
- Acts as a dual-targeting modulator
- Functions as a CB2R agonist and FAAH inhibitor
- Exhibits Ki values of 20.1 nM for CB2R and 67.6 nM for CB1R
- Has an IC50 value of 3.4 μM for FAAH
- Reduces pro-inflammatory cytokines such as TNFα, IFN-γ, IL-1β, and IL6 in unstimulated monocytes and macrophages at 10 μM
Medchemexpress LLC LRH-1 modulator-1 | 2244781-29-9 | 99.4% | 464.66 | 5 MG
(+)-LRH-1 modulator-1 is a stereoisomer of LRH-1 modulator-1. LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. It has anti-inflammatory effects in intestinal organoids, inducing the anti-inflammatory cytokine IL-10 and reducing the inflammatory cytokines IL-1b and TNFa.
- Potent LRH-1 modulator/agonist
- Anti-inflammatory effects in intestinal organoids
- Induces anti-inflammatory cytokine IL-10
- Reduces inflammatory cytokines IL-1b and TNFa
Medchemexpress LLC (R)-Sulforaphane | 142825-10-3 | 99.95% | 177.29 | 5 MG
(R)-Sulforaphane is an orally active and potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. It primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. This compound modulates gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and AP-1.
- Can be used in studies of tumor biology, antioxidant defense mechanisms, inflammation, and immune responses
- Promotes transcription of tumor-suppressing proteins
- Effectively inhibits HDAC activity
- Offers cardiac protection by activating the Keap1/Nrf2/ARE pathway and inducing HO-1 expression
- Suppresses high glucose-induced pancreatic cancer via AMPK-dependent signal transmission
- Storage at -20°C, protect from light, stored under nitrogen
- Unstable in solutions, freshly prepared is recommended
Medchemexpress LLC Sonidegib metabolite 50mg | 1221722-10-6 | 296.24 g·mol⁻¹ | C15H11F3O3 | 50 MG
Sonidegib metabolite M48 (2-methyl-3-[4-(trifluoromethoxy)phenyl]benzoic acid) is the primary circulating metabolite of sonidegib, supplied as a research-grade reference standard for pharmacokinetic, metabolic, and analytical studies.
- For research use only; not for human or clinical use.
- High purity: 98.0%.
- White to off-white solid, stable under recommended storage.
- Comprehensive analytical data available (COA, HNMR, LC-MS).
- Recommended storage: room temperature (solid) for up to 3 years; in solvent: -80°C for 2 years, -20°C for 1 year.
- Suitable as a reference standard for PK and metabolism studies.
Medchemexpress LLC Quetiapine sulfoxide dihydrochloride | 329218-11-3 | MFCD09031385 | 98.6% | 472.43 g·mol-1 | C21H27Cl2N3O3S | 10 MG
Quetiapine sulfoxide dihydrochloride is the dihydrochloride salt of quetiapine sulfoxide, a primary metabolite of the antipsychotic quetiapine. It is provided as a research-grade biochemical reference for analytical, metabolic, and pharmacokinetic studies.
- Main metabolite of quetiapine used in metabolism research and metabolite identification.
- Provided as a stable dihydrochloride salt to improve solubility and handling.
- High purity suitable for analytical and reference-standard applications.
- Available in small milligram pack sizes and as a 10 mM solution for assay preparation.
TARGETMOL CHEMICALS INC NOT Receptor Modulator 1 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.NOT Receptor Modulator 1 (2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol) is a modulator of nuclear receptor NOT. Purity 97.01%
Medchemexpress LLC Iduronate 2-sulfatase, recombinant human (His-tag) | 50936-59-9 | >95.0% | 5 UG
Recombinant human iduronate 2-sulfatase (IDS) produced in HEK293 cells and provided as a lyophilized, C-terminal His-tagged protein for research applications. The glycosylated enzyme is highly pure and supplied with low endotoxin; enzymatic activity is reported by manufacturer assay. Follow storage and reconstitution instructions for optimal stability.
- Expressed in HEK293 cells
- C-terminal His tag for purification and detection
- Purity >95.0% by reducing SDS-PAGE
- Endotoxin <1 EU/μg
- Specific activity ~6.1 pmoL/min/μg
- Lyophilized formulation; reconstitute per instructions
- Store frozen; aliquot to avoid freeze-thaw
Apexbio Technology LLC Sulindac sulfone 59864-04-9 5mg
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation
Medchemexpress LLC GPR120 modulator 1 | 1050506-75-6 | 98.1% | 389.85 g/mol | C19H16ClNO4S | 10 MG
GPR120 modulator 1 is a small-molecule research compound used to modulate G protein-coupled receptor 120 (GPR120) in studies of metabolic and inflammatory pathways. It is intended for in vitro and preclinical research use and is supplied as a purified solid with reported purity suitable for biochemical assays.
- Small-molecule modulator of GPR120 for receptor biology studies.
- High reported purity for reliable assay performance.
- Available in small pack sizes suitable for screening and characterization.
- Provided with supporting documents including datasheet and safety information.
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Medchemexpress LLC Sodium butane-1-sulfonate | 2386-54-1 | MFCD00007540 | 98.0% | 160.17 g·mol⁻¹ | C4H9NaO3S | 100 MG
Sodium butane-1-sulfonate is the sodium salt of 1-butanesulfonic acid used as a reagent in chromatographic and analytical workflows. It is water-soluble and commonly employed as a mobile phase additive to improve separation of arsenic and selenium species in HPLC and related methods. Typical specifications include a molecular weight of 160.17 g·mol⁻¹ and high purity suitable for analytical applications.
- Water-soluble sodium salt suitable for aqueous mobile phases.
- Facilitates chromatographic separation of arsenic and selenium compounds.
- High purity for analytical and HPLC applications.
- Available in small-scale lab pack sizes for research use.
- Stable solid form with molecular weight 160.17 g·mol⁻¹.
eMolecules 67-68-5 | Dimethyl Sulfoxide | AA Blocks LLC | MFCD00002089 | 78.130 | C2H6OS | 0.000 | CS(C)=O | 5g | 784389375
Dimethyl Sulfoxide | AA Blocks LLC | 67-68-5 | MFCD00002089 | 78.130 | C2H6OS | 0.000 | CS(C)=O | 5g | 784389375
Medchemexpress LLC NR2F6 modulator-1 | 904449-84-9 | 99.5% | 419.45 | 100 MG
NR2F6 modulator-1 is a potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator. It can be used for researching immune modulation and modulation of cancer stem cell activity.
- Potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator.
- Useful for researching immune modulation.
- Useful for researching modulation of cancer stem cell activity.
Medchemexpress LLC Sulindac | 38194-50-2 | 99.68% | C20H17FO3S | 100 MG
Sulindac (MK-231) is an orally active nonsteroidal anti-inflammatory agent and an immunomodulatory agent. It is used for the research of arthritis of the spine, gouty arthritis, and various cancers, including colorectal cancer (CRC) and lung cancer.
- Store powder at -20°C for 3 years or 4°C for 2 years.
- Store in solvent at -80°C for 2 years or -20°C for 1 year.