Sulfoxides
![Medchemexpress LLC N-{4-[(2-chloro-6-fluorobenzyl)oxy]-3-methoxybenzyl}-2-(morpholin-4-yl)ethanamine | 875005-43-9 | 99.6% | C21H26ClFN2O3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259354.png-250.jpg)
Medchemexpress LLC N-{4-[(2-chloro-6-fluorobenzyl)oxy]-3-methoxybenzyl}-2-(morpholin-4-yl)ethanamine | 875005-43-9 | 99.6% | C21H26ClFN2O3 | 10MG
GLP-1R modulator C16 is a small-molecule allosteric modulator that enhances glucagon-like peptide-1 (GLP-1) binding to the GLP-1 receptor via a transmembrane site. Supplied for research use in solid form or as a DMSO solution, it is characterized by micromolar potency and high reported purity, and is intended for in vitro pharmacology and receptor modulation studies.
- Enhances GLP-1 binding to the GLP-1 receptor via a transmembrane allosteric site.
- Micromolar potency with EC50 ≈ 8.43 ± 3.82 μM.
- High purity suitable for biochemical and cell-based assays.
- Available as a solid and as a 10 mM solution in DMSO.
- Recommended storage: powder -20°C (long term) or 4°C; in solvent -80°C (long term).
Medchemexpress LLC CXCR7 modulator 2 | 2227426-37-9 | 98.7% | 522.68 | 100 MG
CXCR7 modulator 2 is a small molecule modulator of C-X-C Chemokine Receptor Type 7 (CXCR7) with a Ki of 13 nM. This compound exhibits potent CXCR7-binding affinity and β-arrestin activity, offering improved selectivity in GPCR panels and an enhanced therapeutic index in hERG patch-clamp assays. It demonstrates good aqueous solubility and is suitable for research applications.
- Potent CXCR7-binding affinity (Ki=13 nM)
- Beta-arrestin activity (EC50=11 nM)
- Improved selectivity in GPCR panel
- Improved therapeutic index in hERG patch-clamp assay
- Moderate to high in vitro turnover
- Good aqueous solubility
- Rapidly absorbed in vivo
- Reduces cardiac fibrosis in injury models
- Soluble in DMSO
Medchemexpress LLC Nur77 modulator 3 | 2097787-75-0 | 99.0% | 308.40 | 100 MG
Nur77 modulator 3 is a Nur77 modulator that induces Nur77 expression, inhibits hepatic stellate cells (HSCs) activation, and reduces extracellular matrix (ECM) deposition. It enhances Nur77-dependent autophagic flux and significantly inhibits the mTORC1 signaling pathway. This modulator can ameliorate HSCs activation, inflammation, and hepatic fibrosis *in vivo*.
- Induces Nur77 expression
- Inhibits hepatic stellate cells (HSCs) activation
- Reduces extracellular matrix (ECM) deposition
- Enhances Nur77-dependent autophagic flux
- Significantly inhibits the mTORC1 signaling pathway
- Ameliorates HSCs activation, inflammation, and hepatic fibrosis *in vivo*
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 50 MG
GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 8.43 ± 3.82 μM).
- Enhances GLP-1 binding to GLP-1R.
- Acts via a transmembrane site.
- High purity of 98.7% confirmed by LCMS.
- Recommended storage conditions for powder: -20°C for 3 years, 4°C for 2 years.
- Recommended storage conditions for in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC GPR120 modulator 2 | 1050506-87-0 | 97.1% | 387.88 | C20H18ClNO3S | 10 MG
GPR120 modulator 2 is a small-molecule research compound that modulates the free fatty acid receptor GPR120 and is intended for in vitro pharmacology and metabolic signaling studies.
- Targets the free fatty acid receptor GPR120.
- Molecular formula C20H18ClNO3S and molecular weight 387.88.
- CAS number 1050506-87-0 for unambiguous identification.
- High purity (97.1%) suitable for research applications.
- Available in small pack sizes, including 10 mg.
- Storage: powder at -20°C for long-term stability, 4°C short term; in solvent store at -80°C.
TARGETMOL CHEMICALS INC AMPA RECEPTOR MODULATOR- 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AMPA receptor modulator-1 can be activated by glutamate thereby modulating ion channels. purity: 98%
Medchemexpress LLC IL-17 modulator 1 (disodium) | 2446803-91-2 | 98.4% | C28H35N6Na2O6P | 25 MG
IL-17 modulator 1 disodium is an orally active, highly efficacious small molecule IL-17 modulator. It is designed for research into diseases such as psoriasis, ankylosing spondylitis, and psoriatic arthritis. The disodium salt form provides enhanced water solubility and stability, making it suitable for various research applications.
- Orally active and highly efficacious small molecule
- Enhanced water solubility and stability
- Useful for research into psoriasis
- Useful for research into ankylosing spondylitis
- Useful for research into psoriatic arthritis
Medchemexpress LLC Cytochrome P450 17A1 Antibody (YA478 | 57 kDa | 50 UL
The Cytochrome P450 17A1 Antibody (YA478) is a rabbit host antibody designed for research applications. It is supplied as a liquid with a concentration of 1.0 mg/mL and reacts with human, mouse, and rat samples.
- Reacts with human, mouse, and rat samples
- Suitable for Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, and Flow Cytometry
- Formulated in TBS (pH 7.4), 0.05% BSA, and 40% Glycerol
- Contains 0.05% Sodium Azide as a preservative
- Stable for 1 year when stored at -20°C
- Avoid repeated freeze/thaw cycles
eMolecules 67-68-5 | Dimethyl Sulfoxide | AA Blocks LLC | MFCD00002089 | 78.130 | C2H6OS | 0.000 | CS(C)=O | 500g | 598385589
Dimethyl Sulfoxide | AA Blocks LLC | 67-68-5 | MFCD00002089 | 78.130 | C2H6OS | 0.000 | CS(C)=O | 500g | 598385589
Medchemexpress LLC IL-17 modulator 4 | 2446803-65-0 | >99.0% | C27H34N6O2 | 1 MG
IL-17 modulator 4 is a proagent of IL-17 modulator 1, an orally active and highly efficacious IL-17 modulator. This compound is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome. It modulates IL-17A protein-protein interaction by stabilizing the conformation of the IL-17A dimer, preventing binding to the IL-17RA receptor and inhibiting the IL-17A-mediated signaling pathway. It demonstrates favorable pharmacokinetic properties with excellent oral bioavailability.
- Modulates IL-17A protein-protein interaction
- Stabilizes IL-17A dimer conformation
- Inhibits IL-17A-mediated signaling pathway
- Potential for research in inflammation and autoimmune diseases
- Exhibits good pharmacokinetic properties in rat models
- Offers high oral bioavailability
Medchemexpress LLC Sirtuin modulator 3 10mM 1mL | 1mL
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]
Medchemexpress LLC Sodium decane-1-sulfonate | 13419-61-9 | 244.33 | 1 G
Sodium decane-1-sulfonate is an anionic surfactant primarily used for the analysis of organic small molecule compounds by HPLC and ion-pair liquid chromatography. It appears as a solid and is intended for research use only.
- Anionic surfactant
- Used for analysis of organic small molecule compounds
- Applicable in HPLC and ion-pair liquid chromatography
- Solid appearance
- For research use only