Sulfoxides
Medchemexpress LLC Tnfa Activ Modulator 3 Reconst | HY-160412-1MM/1ML RECONST
Tnfa Activ Modulator 3 Reconst
Medchemexpress LLC GLP-1R modulator C5 | 421578-93-0 | 99.8% | C24H21NO3 | 10MG
GLP-1R modulator C5 is a small-molecule allosteric modulator that enhances GLP-1 binding to the GLP-1 receptor via a transmembrane site. It is intended for research use and is characterized by an EC50 of 1.59 ± 0.53 μM, molecular formula C24H21NO3, and molecular weight 371.43 g·mol⁻1.
- Allosteric enhancer of GLP-1 binding to GLP-1R.
- Measured EC50 of 1.59 ± 0.53 μM.
- Available as solid (5-100 mg) and 10 mM solution in DMSO.
- High purity (99.81% by LCMS).
- Supplied with certificate of analysis for analytical verification.
Medchemexpress LLC IL-17 modulator 4 | 2446803-65-0 | >99.0% | C27H34N6O2 | 1 ML
IL-17 modulator 4 is a proagent of IL-17 modulator 1, active against IL-17A mediated diseases. This orally active modulator shows promise for the research of conditions including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome. It inhibits IL-17A-mediated signaling pathways by stabilizing the IL-17A dimer and preventing its binding to the IL-17RA receptor.
- Modulates IL-17A protein-protein interaction
- Stabilizes IL-17A dimer conformation
- Prevents IL-17A from binding to IL-17RA receptor
- Inhibits IL-17A-mediated signaling pathways
- Exhibits good pharmacokinetic properties in rat models
- Oral bioavailability of 100% in rat models
Medchemexpress LLC Sulforaphane | 4478-93-7 | 99.75% | 177.29 | 200 MG
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. It promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. It protects the heart through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission and exhibits both anticancer and anti-inflammatory properties.
- Targets: HDAC, Keap1-Nrf2, Apoptosis, Bcl-2 family, Caspase, Reactive oxygen species (ROS)
- Research areas: Inflammation/Immunology, Cancer
eMolecules (4-(METHYLSULFINYL)PHENYL)METHANAMINE HCL | 1189719-93-4 | MFCD11100897 | 1g
AstaTech | (4-(METHYLSULFINYL)PHENYL)METHANAMINE HCL | 1g | 112531629 | AR2414 | 95.000 | 1189719-93-4 | MFCD11100897 | 205.700 | C8H12ClNOS
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Medchemexpress LLC Ritonavir metabolite (Desthiazolylmethyloxycarbonyl Ritonavir) | 176655-55-3 | 99.6% | 579.80 | 5 MG
Ritonavir metabolite is a metabolite of Ritonavir, which is an HIV protease inhibitor. The product appears as a white to off-white solid.
- Purity of 99.6%
- Molecular weight of 579.80
- CAS number 176655-55-3
- Storage at -20°C for powder, -80°C for 6 months in solvent
- Shipping at room temperature in continental US
Medchemexpress LLC Smurf1 modulator-1 | 1825371-51-4 | 99.8% | 446.54 | 5 MG
Smurf1 modulator-1 (Compound 20) is a selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1), with IC50 of 180 nM.
- Selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1) with an IC50 of 180 nM.
- For research use only.
Medchemexpress LLC Nourseothricin sulfate | 96736-11-7 | 99.9% | 25 MG
Nourseothricin sulfate is a broad-spectrum antibiotic that targets the outer membrane of Gram-negative bacteria. It inhibits protein biosynthesis in prokaryotic cells and suppresses the growth of eukaryotes like fungi. It can also be utilized as a selective marker for a wide array of organisms.
- Broad-spectrum antibiotic
- Targets outer membrane of Gram-negative bacteria
- Serves as a dominant selective marker for *Fonsecaea pedrosoi*
- Inhibits protein biosynthesis in prokaryotic cells
- Suppresses the growth of eukaryotes like fungi
- Can be used as a selective marker for various organisms, including bacteria, yeast, filamentous fungi, and plant cells
Medchemexpress LLC Acetic acid, 2-[4-[[4-(2-chlorophenyl)-2-thiazolyl]methoxy]-2-methylphenoxy]- | 1050506-75-6 | 98.1% | C19H16ClNO4S | 1 ML
GPR120 modulator 1 is a G protein coupled receptor 120 (GPR120) modulator. This compound, extracted from patent US8394841B2 (compound example F1), is suitable for research into diseases linked to abnormal or deregulated GPR120, including diabetes.
- Modulates G protein coupled receptor 120 (GPR120)
- Supports research on diseases linked to GPR120 deregulation, such as diabetes
- Purity of 98.1% (HPLC)
- White to off-white solid appearance
- Chemical formula C19H16ClNO4S
Sigma Aldrich Fine Chemicals Biosciences Cytochrome P450 3A4 human
Supplied as purified soluble proteins rather than microsomal preparations.
Medchemexpress LLC Iduronate 2-sulfatase, recombinant human (His-tag) | 50936-59-9 | >95.0% | 5 UG
Recombinant human iduronate 2-sulfatase (IDS) produced in HEK293 cells and provided as a lyophilized, C-terminal His-tagged protein for research applications. The glycosylated enzyme is highly pure and supplied with low endotoxin; enzymatic activity is reported by manufacturer assay. Follow storage and reconstitution instructions for optimal stability.
- Expressed in HEK293 cells
- C-terminal His tag for purification and detection
- Purity >95.0% by reducing SDS-PAGE
- Endotoxin <1 EU/μg
- Specific activity ~6.1 pmoL/min/μg
- Lyophilized formulation; reconstitute per instructions
- Store frozen; aliquot to avoid freeze-thaw
Apexbio Technology LLC Sulindac sulfone 59864-04-9 5mg
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation
Cayman Chemical Sulforaphane Inhibitors
An isothiocyanate that potently induces chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression; at 15 μM, inhibits class I and II HDAC activity and suppresses tumor growth selectively in cancerous prostate epithelial cells without affecting normal cells
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg