Sulfoxides
Medchemexpress LLC 4-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(pyridin-3-yl)quinazoline | 796079-91-9 | 97.0% | 338.41 g/mol | C22H18N4 | 10 MG
GCase modulator-1 (compound 9g) is a quinazoline-derivative small molecule reported to modulate glucocerebrosidase (GCase) activity (reported AC50 = 2.23 μM). It is supplied as a research-grade powder for use in biochemical assays and in vitro studies; reported molecular weight is 338.41 g/mol and reported purity is ~97%.
- Modulates GCase (glucosidase) with reported AC50 = 2.23 μM.
- Quinazoline-derived small-molecule scaffold suitable for biochemical studies.
- Provided as a powder for preparation of assay solutions.
- Reported purity approximately 97% and molecular weight 338.41 g/mol.
- Intended for research use in vitro; not for human or clinical use.
Cayman Chemical Sulindac sulfide
An active metabolite of sulindac; inhibits COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications; inhibits colorectal cancer growth in vitro and in vivo
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide suitabl
Dimethyl sulfoxide (DMSO) is a polar organic solvent. DMSO activated by various electrophiles (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. Due to its higher stability it has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction.
Medchemexpress LLC Cytochrome P450 2E1 antibody (YA2302) | 100 UL
Cytochrome P450 2E1 antibody (YA2302) is a rabbit-derived and non-conjugated IgG monoclonal antibody targeting Cytochrome P450 2E1. It is for research use only.
- Host: Rabbit
- Clonality: Recombinant, monoclonal
- Species reactivity: Human, mouse, rat
- Immunogen: A synthesized peptide derived from human CYP2E1 aa52-114
- Application & dilution ratio: WB 1:500-1:1000
- Sensitivity: Endogenous
- Conjugation: Non-conjugated
- Modification: Unmodified
- Isotype: IgG
- Appearance: Liquid
- Formulation: Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol
- Storage & stability: Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles
- Shipping: Shipping with blue ice
eMolecules 79685-17-9 | 5-Bromo-2-(methylsulfinyl)pyrimidine | MFCD19689658 | 1g
Ambeed | 5-Bromo-2-(methylsulfinyl)pyrimidine | 1g | 600835143 | A245047 | 79685-17-9 | MFCD19689658 | 221.070 | C5H5BrN2OS
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Medchemexpress LLC (R)-IL-17 modulator 4 | 2446804-29-9 | 99.6% | C27H34N6O2 | 1 ML
(R)-IL-17 modulator 4 is the R-configure of IL-17 modulator 4. It is a proagent of IL-17 modulator 1, which is an orally active, highly efficacious IL-17 modulator. This product is promising for research into IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome. It is for research use only and not sold to patients.
- R-enantiomer of IL-17 modulator 4
- Functions as a proagent of IL-17 modulator 1
- Orally active and highly efficacious IL-17 modulator
- Potentially useful for research into IL-17A mediated diseases
- Supports studies on inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome
- For research use only
- High purity of 99.6%
- Molecular weight of 474.60
- Chemical formula C27H34N6O2
- Solid appearance
- Off-white to gray color
- Targets IL-17
TARGETMOL CHEMICALS INC AMPA RECEPTOR MODULATOR- 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARP(gamma)2 dependent AMPA receptor is 10.1. purity: 99%
TARGETMOL CHEMICALS INC ABEMACICLIB METABOLITE M 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Abemaciclib metabolite M20 (CDK4/6-IN-4) is an active metabolite of Abemaciclib. Abemaciclib metabolite M20 is a selective CDK4/6 inhibitor and can be used for researches on the treatment of cancer. purity: 98%
Medchemexpress LLC IL-17A modulator-1 | 2748749-29-1 | 98.8% | C33H31N5O4 | 25 MG
IL-17A modulator-1 is a compound that modulates the activity of IL-17A, an important cytokine involved in immune responses. Derived from patent WO2021239743+A1, this modulator inhibits the biological action of IL-17A with a pIC50 of 8.2, making it suitable for research into various diseases and disorders associated with IL-17A activity, including those with immune components, autoimmune pathologies, cancer, and neurodegenerative disorders. The product is provided as a white to off-white solid.
- Modulates IL-17A activity
- Inhibits biological action of IL-17A
- Suitable for research into immune, autoimmune, cancer, and neurodegenerative disorders
- White to off-white solid appearance
Cayman Chemical AM630 Other Receptor Modulator
An inverse agonist at CB2 and partial agonist at CB1 receptors; binds selectively to CB2 over CB1 receptors (Kis = 31.2 and 5,152 nM, respectively); blocks the antinociceptive effects of cannabinoids; decreases proliferation and induces cell cycle arrest in renal cell carcinoma cells
Cayman Chemical AM630 Other Receptor Modulator
An inverse agonist at CB2 and partial agonist at CB1 receptors; binds selectively to CB2 over CB1 receptors (Kis = 31.2 and 5,152 nM, respectively); blocks the antinociceptive effects of cannabinoids; decreases proliferation and induces cell cycle arrest in renal cell carcinoma cells
eMolecules 1774-35-2 | Ambeed | p-Tolyl Sulfoxide | 5g | 536766794 | A760993 | MFCD00008546 | 230.33 | C14H14OS
Ambeed | 6-Chloro-2-(trifluoromethyl)nicotinic acid | 100mg | 525078663 | A163084 | 261635-83-0 | MFCD11840271 | 225.550 | C7H3ClF3NO2
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Medchemexpress LLC Sonidegib metabolite 25mg | 1221722-10-6 | 25 MG
Sonidegib metabolite M48 is the primary circulating metabolite of sonidegib, provided as a research-grade chemical for laboratory studies. The compound has formula C15H11F3O3, molecular weight 296.24 g·mol⁻¹, and is supplied with documented purity and storage recommendations for research use only.
- Research use only; not for human or clinical use.
- High reported purity: 98.0%.
- White to off-white solid suitable for analytical and in vitro studies.
- Available in small research quantities for assay development and metabolic studies.
- Stable at room temperature for up to 3 years under recommended storage conditions.
Medchemexpress LLC Sirtuin modulator 3 100mg | 100mg
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]
Apexbio Technology LLC Sulindac sulfone 59864-04-9 10mg
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation