Sulfoxides
Medchemexpress LLC MRGPRX2 modulator-1 | 2781839-42-5 | 99.03% | 459.39 | 5 MG
MRGPRX2 modulator-1 (example 17) is a mas-related g-protein receptor x2 (MRGPRX2) modulator. It can be used for the research of inflammation, pain, and autoimmune disorders.
- Research Reagent: For research use only.
- High Purity: 99.03%.
- Versatile Application: Useful for studying inflammation, pain, and autoimmune disorders.
- Multiple Formats: Available as solid or in DMSO solution.
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | 99.9% | 1 ML
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. This product is designed for researching Alzheimer's disease.
- Potent γ-secretase modulator
- Selectively reduces Aβ42 production
- Favors shorter Aβ species
- Suitable for Alzheimer's disease research
Medchemexpress LLC KAT modulator-1 (Compound 3) | 1314006-43-3 | 98.0% | 308.50 | C20H36O2 | 10 MG
KAT modulator-1 is a small-molecule modulator of lysine acetyltransferase (KAT) activity developed for epigenetics research. It has been shown to interact with full-length p300 but not with the isolated catalytic domain, making it a useful probe for studying KAT-protein interactions and regulatory mechanisms in biochemical and cell-based assays. The compound is supplied as a solid with documented storage recommendations and analytical data.
- Modulates lysine acetyltransferase (KAT) activity.
- Interacts with full-length p300 but not the catalytic domain.
- Suitable for biochemical and cell-based epigenetics studies.
- Supplied as a solid with defined storage stability.
- Molecular formula C20H36O2 and molecular weight 308.50.
- High chemical purity typically reported (about 98%).
Medchemexpress LLC 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-(2-oxo-2-phenylethyl)-1-(2-phenylethyl)- | 421578-93-0 | 99.8% | C24H21NO3 | 25 MG
GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM).
- Enhances GLP-1 binding to GLP-1R.
- Acts via a transmembrane site.
- High purity of 99.8%.
- White to off-white solid.
- Suitable for research applications.
Medchemexpress LLC Mutant p53 modulator-1 | 2746371-35-5 | 99.9% | C27H32F4N8O2 | 1 ML
Mutant p53 modulator-1 is a compound that acts as a modulator of mutant p53. It has been shown to reduce the progression of cancers that possess a p53 mutation. This compound is identified as 231B in patent WO2021231474A1.
- Molecular weight: 576.59
- Appearance: Solid
- Color: Light yellow to brown
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Powder at -20°C for 3 years, 4°C for 2 years. In solvent at -80°C for 6 months, -20°C for 1 month
- Solubility (in vitro): 100 mg/mL (173.43 mM) in DMSO (requires sonication; hygroscopic DMSO significantly impacts solubility, use newly opened DMSO)
TARGETMOL CHEMICALS INC CALCIUM CHANNEL-MODULATO 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Calcium channel-modulator-1 is a calcium channel-modulator (IC500.8 uM) with specialisation to block aortic constriction. purity: 99%
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 50 MG
GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 8.43 ± 3.82 μM).
- Enhances GLP-1 binding to GLP-1R.
- Acts via a transmembrane site.
- High purity of 98.7% confirmed by LCMS.
- Recommended storage conditions for powder: -20°C for 3 years, 4°C for 2 years.
- Recommended storage conditions for in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC GPR120 modulator 2 | 1050506-87-0 | 97.1% | 387.88 | C20H18ClNO3S | 10 MG
GPR120 modulator 2 is a small-molecule research compound that modulates the free fatty acid receptor GPR120 and is intended for in vitro pharmacology and metabolic signaling studies.
- Targets the free fatty acid receptor GPR120.
- Molecular formula C20H18ClNO3S and molecular weight 387.88.
- CAS number 1050506-87-0 for unambiguous identification.
- High purity (97.1%) suitable for research applications.
- Available in small pack sizes, including 10 mg.
- Storage: powder at -20°C for long-term stability, 4°C short term; in solvent store at -80°C.
Medchemexpress LLC IL-17 modulator 3 | 2467731-88-8 | 99.51% | 579.73 | 1 ML
IL-17 modulator 3 is an IL-17 modulator that can be used for the research of inflammation, cancer, and autoimmune diseases. This product is for research use only and not sold to patients.
- Used for research of inflammation
- Used for research of cancer
- Used for research of autoimmune diseases
![Medchemexpress LLC N-[(1S)-1-cycloheptyl-2-[4-[(2R)-3-(4-methylpiperazin-1-yl)-3-oxo-2-(propanoylamino)propyl]anilino] | 2467731-88-8 | 99.5% | C31H45N7O4 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260756.png-250.jpg)
Medchemexpress LLC N-[(1S)-1-cycloheptyl-2-[4-[(2R)-3-(4-methylpiperazin-1-yl)-3-oxo-2-(propanoylamino)propyl]anilino] | 2467731-88-8 | 99.5% | C31H45N7O4 | 10MG
IL-17 modulator 3 is a small-molecule IL-17 pathway modulator intended for research use in studies of inflammation, cancer, and autoimmune diseases. It is provided as a chemically characterized research reagent with documentation of purity and structural identifiers suitable for in vitro and preclinical investigations.
- High purity (99.5%).
- Solid powder with light yellow to yellow appearance.
- Molecular formula C31H45N7O4 and molecular weight 579.73.
- Structural identifiers available (SMILES and PubChem CID documented).
- Supplied in a 10 mg quantity for laboratory research use.
- Intended for use in inflammation, cancer, and autoimmune disease research applications.
TARGETMOL CHEMICALS INC AMPA RECEPTOR MODULATOR- 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AMPA receptor modulator-1 can be activated by glutamate thereby modulating ion channels. purity: 98%
Medchemexpress LLC GLP-1R modulator C5 | 421578-93-0 | 99.81% | C24H21NO3 | 50 MG
GLP-1R modulator C5 is an allosteric modulator that enhances GLP-1 binding to GLP-1R through a transmembrane site, with an EC50 of 1.59 ± 0.53 μM. It is intended for research use only.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R
- Intended for research use only
![Medchemexpress LLC 2(3h)-benzothiazolone, 6-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl | 142477-34-7 | 97.1% | 383.51 g/mol | C21H25N3O2S | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000214116.png-250.jpg)
Medchemexpress LLC 2(3h)-benzothiazolone, 6-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl | 142477-34-7 | 97.1% | 383.51 g/mol | C21H25N3O2S | 1 MG
A selective small-molecule research ligand for the 5-HT1A serotonin receptor that also exhibits activity at adrenergic α1 and dopamine D2 receptors. Supplied as a white to off-white solid with supporting analytical documentation (COA and datasheet) for preclinical pharmacology and receptor profiling studies.
- High affinity for 5-HT1A receptor, IC50 ≈ 2 nM.
- Measured off-target activity at adrenergic α1 and dopamine D2 receptors (IC50 ≈ 10 nM and 40 nM).
- Supplied as a stable solid suitable for frozen or refrigerated storage.
- Certificate of analysis and purity data available to support assay reproducibility.
- Useful as a pharmacological tool for serotonin receptor profiling and CNS research.
Medchemexpress LLC Dl-sulforaphane n-acetyl-l-cysteine | 334829-66-2 | 99.9% | 340.48 g/mol | C11H20N2O4S3 | 5 MG
DL-Sulforaphane N-acetyl-L-cysteine is a sulforaphane metabolite used in research as an orally active histone deacetylase (HDAC) inhibitor. It is reported to have an extended half-life and improved blood-brain barrier permeability versus the parent compound, and has been used to study autophagy, HDAC activity, and anticancer mechanisms. Supplied as a high-purity solid for laboratory research.
- Orally active HDAC inhibitor and sulforaphane metabolite.
- Longer half-life and improved blood-brain barrier permeability compared with parent compound.
- Reported to induce autophagy, cell-cycle arrest, and apoptosis in certain cancer cell lines.
- High-purity solid suitable for research applications.
- Soluble in DMSO; store powder frozen for long-term stability.