Sulfoxides
Medchemexpress LLC IL-17A modulator-3 | 2467732-95-0 | 99.37% | 639.80 | 25 MG
IL-17A modulator-3 (compound 253) is an IL-17A modulator that inhibits IL-17A/A with an IC50 value of less than 10 μM. This compound is suitable for research into inflammation, cancer, and autoimmune diseases.
- Inhibits IL-17A/A with an IC50 value of less than 10 μM
- Used for research on inflammation, cancer, and autoimmune diseases
- Molecular weight: 639.80
- Appearance: White to off-white solid
Medchemexpress LLC Cytochrome P450 24A1 Antibody (YA2121) | 10 UL
Cytochrome P450 24A1 Antibody (YA2121) is a non-conjugated, Rabbit-derived IgG monoclonal antibody, specifically designed to target Cytochrome P450 24A1. It is intended for research use only.
- Host: Rabbit
- Clonality: Recombinant, Monoclonal
- Species reactivity: Human
- Isotype: IgG
- Conjugation: Non-conjugated
- Formulation: Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
- Storage & stability: Stored at -20°C for 1 year, avoiding repeated freeze/thaw cycles.
- Applications: Western blot (WB) with a dilution ratio of 1:500-1:1000.
- Function: This cytochrome P450 monooxygenase is crucial for vitamin D catabolism and calcium homeostasis, inactivating calcidiol and calcitriol through C24- and C23-oxidation pathways.
- Subcellular localization: Mitochondrion
Medchemexpress LLC Sodium decane-1-sulfonate | 13419-61-9 | 244.33 | 5 G
Sodium decane-1-sulfonate is an anionic surfactant primarily used for the analysis of organic small molecule compounds via HPLC and ion-pair liquid chromatography. This product is intended for research use only and is not sold to patients.
- Anionic surfactant
- Used for analysis of organic small molecule compounds
- Applied in HPLC
- Applied in ion-pair liquid chromatography
- For research use only
Medchemexpress LLC Sonidegib metabolite 25mg | 1221722-10-6 | 25 MG
Sonidegib metabolite M48 is the primary circulating metabolite of sonidegib, provided as a research-grade chemical for laboratory studies. The compound has formula C15H11F3O3, molecular weight 296.24 g·mol⁻¹, and is supplied with documented purity and storage recommendations for research use only.
- Research use only; not for human or clinical use.
- High reported purity: 98.0%.
- White to off-white solid suitable for analytical and in vitro studies.
- Available in small research quantities for assay development and metabolic studies.
- Stable at room temperature for up to 3 years under recommended storage conditions.
Medchemexpress LLC 3',4'-Tetramethylene-α-pyrrolidinobutiophenone hydrochloride | 2749504-65-0 | 99.9% | 307.86 | 5 MG
This product is a laboratory chemical, 3',4'-Tetramethylene-α-pyrrolidinobutiophenone hydrochloride, intended for research use only and suitable for the manufacture of substances. It should be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities. The substance is stable under recommended storage conditions but is incompatible with strong acids/alkalis and strong oxidizing/reducing agents. It is not classified as a hazardous substance or mixture.
- Identified for laboratory use and substance manufacturing.
- Stable under recommended storage conditions.
- High purity of 99.9%.
- Molecular formula C18H26CINO.
- Powder storage: -20°C for 3 years, 4°C for 2 years.
- In solvent storage: -80°C for 6 months, -20°C for 1 month.
- Not a hazardous substance or mixture.
Medchemexpress LLC 3-isoxazolecarboxamide, N-(2-cyclohexyl-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazol-4-yl)-4-methyl-5-... | 1825371-51-4 | 99.8% | 446.54 | 1 MG
Smurf1 modulator-1 (Compound 20) is a selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1), with an IC50 of 180 nM. This product is for research use only and not sold to patients.
- Selective inhibitor for Smad ubiquiquitination regulatory factor 1 (Smurf1).
- IC50 of 180 nM.
- For research use only.
- Appearance is a white to off-white solid.
- Specific storage conditions for powder and in solvent.
- Soluble in DMSO.
Medchemexpress LLC Hydrazinecarbothioamide, 2-(1H-indol-3-ylmethylene)-N-(4-methylphenyl)-, (2E)- | 2097787-75-0 | 99.0% | 308.40 | 25 MG
Hydrazinecarbothioamide, 2-(1H-indol-3-ylmethylene)-N-(4-methylphenyl)-, (2E)- | 2097787-75-0 | 99.0% | 308.40 | 25 MG
Medchemexpress LLC Elafibranor sulfoxide | 95.0% | 400.49 | 25 MG
Elafibranor (GFT505) sulfoxide is a sulfoxide metabolite of Elafibranor (HY-16737). Elafibranor is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively. Elafibranor can be used for the study of primary biliary cholangitis.
- Purity: 95.0%
- Molecular weight: 400.49
- Formula: C22H24O5S
- Appearance: Solid
- Color: Light yellow to yellow
- Solubility (in vitro): 100 mg/mL (DMSO)
- Storage (powder): -20°C 3 years, 4°C 2 years
- Storage (in solvent): -80°C 6 months, -20°C 1 month
- Research use only
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Cayman Chemical AM630 Other Receptor Modulator
An inverse agonist at CB2 and partial agonist at CB1 receptors; binds selectively to CB2 over CB1 receptors (Kis = 31.2 and 5,152 nM, respectively); blocks the antinociceptive effects of cannabinoids; decreases proliferation and induces cell cycle arrest in renal cell carcinoma cells