Sulfoxides
AdipoGen Diquat metabolite dipyridone
Chemical. CAS 35022-72-1. Formula C12H10N2O2. MW BD9837. Diquat metabolite dipyridone is a common degradation product of diquat. Diquat is a nonselective, defoliant, preharvest, and non-residual bipyridyl herbicide and crop desiccant, normally used as the dibromide salt, to control broad-leaved weeds and grasses. Its activity is based on the liberation of the superoxide anion radical and, subsequently, hydrogen peroxide, leading to tissue destruction by oxidative stress. This compound can be used as a reference compound for analytical studies.
Medchemexpress LLC Cytochrome P450 2E1 Antibody (YA2302) | 10 UL
Cytochrome P450 2E1 Antibody (YA2302) is a rabbit-derived, non-conjugated IgG monoclonal antibody that specifically targets Cytochrome P450 2E1. It is designed for research use and has applications in Western Blot (WB) for human, mouse, and rat species. This antibody is formulated in 10mM PBS, pH 7.4, containing 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide, and 50% glycerol.
- Monoclonal antibody targeting Cytochrome P450 2E1.
- Suitable for Western Blot (WB) applications.
- Reacts with human, mouse, and rat samples.
- Immunogen derived from human CYP2E1 aa52-114.
- Non-conjugated and unmodified.
Medchemexpress LLC Cytochrome P450 2C9 antibody (YA2166) | 50 UL
Cytochrome P450 2C9 Antibody (YA2166) is a Rabbit-derived, non-conjugated IgG monoclonal antibody targeting Cytochrome P450 2C9. It is for research use only.
- Rabbit-derived IgG monoclonal antibody
- Targets Cytochrome P450 2C9
- Reactivity: Human
- Applications: WB (1:500-1:1000), ICC/IF (1:50-1:200), FC (1:50-1:100)
- Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol
- Storage at -20°C for 1 year, avoid repeated freeze/thaw cycles
Medchemexpress LLC Cytochrome P450 27A1 antibody (YA2163) | 100 UL
Cytochrome P450 27A1 Antibody (YA2163) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets Cytochrome P450 27A1. This enzyme plays a crucial role in cholesterol homeostasis by catalyzing the hydroxylation of cholesterol and its derivatives, leading to bile acid synthesis and modulation of lipid metabolism genes.
- Rabbit-derived monoclonal antibody
- Targets Cytochrome P450 27A1
- Non-conjugated IgG
- Reactive with human, mouse, and rat samples
- Purified by affinity chromatography
- Predicted band size: 60 kDa; Observed band size: 50 kDa
- Suitable for WB, IHC-P, ICC/IF, and FC applications
Medchemexpress LLC Hsp110/sGC-modulator-1 | 99.6% | 490.86 g·mol⁻1 | C24H18ClF3N2O4 | 10 MG
Hsp110/sGC-modulator-1 is an orally active small-molecule regulator that modulates Hsp110 and soluble guanylate cyclase (sGC). It demonstrates potent dual-target activity, produces vasodilatory effects, and attenuates pulmonary vascular remodeling and right ventricular hypertrophy in preclinical studies. Supplied in milligram quantities for research use only. Molecular formula C24H18ClF3N2O4; molecular weight 490.86 g·mol⁻1; reported purity 99.58%.
- Dual-target activity against Hsp110 and sGC.
- Demonstrated vasodilatory and antiproliferative effects in preclinical models.
- Suitable for in vitro and in vivo preclinical research.
- Supplied in milligram quantities for screening and lead optimization.
- Reported purity 99.58% and characterized by HRMS.
Medchemexpress LLC Iduronate 2-sulfatase protein, human | 50936-59-9 | >95.0% | 1 MG
Recombinant human iduronate 2-sulfatase (IDS) is a lysosomal enzyme produced in HEK293 cells and supplied lyophilized for research use. It participates in the degradation of dermatan sulfate and heparan sulfate, and is suitable for biochemical assays and enzyme activity studies.
- Expression system: HEK293 cells
- Tag: C-terminal His
- Purity: >95.0% by reducing SDS-PAGE
- Molecular weight: ~75-95 kDa (glycosylated)
- Formulation: lyophilized from 0.22 μm filtered PBS, pH 7.4
- Storage: store lyophilized at -20°C; aliquot and freeze at -80°C for long term
- Activity: specific activity ~6.123 pmoL/min/μg
Medchemexpress LLC Cytochrome P450 3A4 Antibody (YA3715) | 10 UL
The CYP3A4 protein, a cytochrome P450 monooxygenase, is intricately involved in the metabolism of a diverse array of substrates, including sterols, steroid hormones, retinoids, and fatty acids. It plays a crucial role in various biological processes such as androgen and cholesterol metabolism, retinoid metabolism, and the oxidative metabolism of xenobiotics, acting as a major contributor to drug metabolism. This antibody also contributes to vitamin D catabolism and calcium homeostasis.
- Mouse-derived and non-conjugated IgG1 monoclonal antibody
- Targets Cytochrome P450 3A4
- Reactivity: Human, mouse, rat
- Formulated in PBS, pH 7.4
- Store at -20°C for 1 year
- Avoid repeated freeze / thaw cycles
- Liquid appearance
- Suitable for WB, IHC-P, ICC/IF, FC, ELISA applications
Medchemexpress LLC Iduronate 2-sulfatase | 50936-59-9 | >95.0% | 500 UG
Recombinant human iduronate 2-sulfatase (IDS) is a lysosomal enzyme produced in HEK293 cells and supplied lyophilized as an active, His-tagged protein for biochemical and enzymatic studies. It hydrolyzes the C2-sulfate ester of glycosaminoglycans and is provided with validated purity and activity specifications.
- Expressed in HEK293 cells.
- C-terminal 10xHis tag for purification.
- Purity >95.0% by reducing SDS-PAGE.
- Specific activity 6.123 pmoL/min/μg (PNCS substrate assay).
- Lyophilized from 0.22 μm filtered PBS, pH 7.4.
- Approximate molecular weight 75-95 kDa due to glycosylation.
- Store at -20°C; after reconstitution stable at 4°C for 1 week.
- Available in a 500 μg size.
Medchemexpress LLC Cytochrome P450 2E1 Antibody (YA2302) | 50 UL
Cytochrome P450 2E1 Antibody (YA2302) is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting Cytochrome P450 2E1. It is for research use only and demonstrates endogenous sensitivity. This antibody is supplied as a liquid formulation in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide, and 50% glycerol.
- Involved in fatty acid metabolism and potentially xenobiotic oxidative metabolism.
- Catalyzes hydroxylation of carbon-hydrogen bonds, specifically at the omega-1 position of saturated fatty acids.
- Subcellular localization includes endoplasmic reticulum membrane, microsome membrane, and mitochondrion inner membrane.
- Application in western blot (WB) with a dilution ratio of 1:500-1:1000.
- Species reactivity includes human, mouse, and rat.
- Immunogen is a synthesized peptide derived from human CYP2E1 aa52-114.
Medchemexpress LLC Cytochrome P450 2E1 antibody (YA2302) | 100 UL
Cytochrome P450 2E1 antibody (YA2302) is a rabbit-derived and non-conjugated IgG monoclonal antibody targeting Cytochrome P450 2E1. It is for research use only.
- Host: Rabbit
- Clonality: Recombinant, monoclonal
- Species reactivity: Human, mouse, rat
- Immunogen: A synthesized peptide derived from human CYP2E1 aa52-114
- Application & dilution ratio: WB 1:500-1:1000
- Sensitivity: Endogenous
- Conjugation: Non-conjugated
- Modification: Unmodified
- Isotype: IgG
- Appearance: Liquid
- Formulation: Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol
- Storage & stability: Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles
- Shipping: Shipping with blue ice
Medchemexpress LLC Cytochrome P450 3A4 Antibody (YA3715) | 50 UL
Cytochrome P450 3A4 (CYP3A4) is a cytochrome P450 monooxygenase extensively involved in the metabolism of various substrates, including sterols, steroid hormones, retinoids, and fatty acids. This protein utilizes molecular oxygen to hydroxylate carbon-hydrogen bonds and contributes significantly to androgen and cholesterol metabolism. It also plays a crucial role in retinoid metabolism by oxidizing all-trans-retinol to all-trans-retinal and is a major contributor to the oxidative metabolism of xenobiotics, influencing drug metabolism, vitamin D catabolism, and calcium homeostasis.
- Mouse-derived antibody
- Reacts with human, mouse, and rat samples
- Non-conjugated for broad application
- Formulated in PBS with 0.05% sodium azide
- Stable for 1 year when stored at -20°C
- Avoid repeated freeze/thaw cycles
- Applicable in WB, IHC-P, ICC/IF, FC, and ELISA experiments
- Liquid appearance
Medchemexpress LLC Cytochrome P450 24A1 Antibody (YA2121) | 10 UL
Cytochrome P450 24A1 Antibody (YA2121) is a non-conjugated, Rabbit-derived IgG monoclonal antibody, specifically designed to target Cytochrome P450 24A1. It is intended for research use only.
- Host: Rabbit
- Clonality: Recombinant, Monoclonal
- Species reactivity: Human
- Isotype: IgG
- Conjugation: Non-conjugated
- Formulation: Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
- Storage & stability: Stored at -20°C for 1 year, avoiding repeated freeze/thaw cycles.
- Applications: Western blot (WB) with a dilution ratio of 1:500-1:1000.
- Function: This cytochrome P450 monooxygenase is crucial for vitamin D catabolism and calcium homeostasis, inactivating calcidiol and calcitriol through C24- and C23-oxidation pathways.
- Subcellular localization: Mitochondrion
Medchemexpress LLC Iduronate 2-sulfatase (recombinant human) | 50936-59-9 | >95.0% | 100 UG
Recombinant human iduronate 2-sulfatase (IDS) expressed in HEK293 cells and supplied as a His-tagged, lyophilized protein for research use. IDS catalyzes removal of 2-sulfate groups from iduronate residues in glycosaminoglycans; the product includes documented purity, endotoxin, activity, and storage specifications to support biochemical and cell-based assays.
- Expressed in HEK293 cells for human-like glycosylation
- C-terminal His tag enables detection and purification
- Lyophilized from PBS (pH 7.4) for stability and convenient handling
- Purity greater than 95% by reducing SDS-PAGE
- Endotoxin level <1 EU/μg, suitable for many cell-based assays
- Specific activity 6.123 pmoL/min/μg measured with PNCS substrate
- Store at -20°C; aliquot and keep at -80°C for extended storage
Medchemexpress LLC Cytochrome P450 2C9 Antibody (YA2166) | 100 UL
Cytochrome P450 2C9 Antibody (YA2166) is a Rabbit-derived, non-conjugated IgG monoclonal antibody targeting Cytochrome P450 2C9. It is for research use only and is involved in the metabolism of various endogenous substrates, including fatty acids and steroids, contributing to the pharmacokinetic variability of drugs.
- Host: Rabbit
- Clonality: Recombinant, monoclonal
- Species reactivity: Human
- Conjugation: Non-conjugated
- Isotype: IgG
- Formulation: Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol
- Storage: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles
- Shipping: Shipping with blue ice
- Application & dilution ratio: WB: 1:500-1:1000; ICC/IF: 1:50-1:200; FC: 1:50-1:100