Flavonoids
Apexbio Technology LLC Catechin 154-23-4 10mg
Catechin (154-23-4) is a small-molecule inhibitor targeting cyclooxygenase-1 (COX-1) It is designed to inhibit COX-1 activity thereby modulating inflammation-related pathways Catechin exerts its biological activity primarily through inhibition of COX-1 In cell-based assays catechin demonstrates inhibitory activity with an IC50 value of approximately 1 4 M Based on these pharmacological properties catechin holds research potential in studies of oxidative stress pathways inflammation processes and enzyme inhibition screening
Medchemexpress LLC 7,8-Dihydroxyflavone | 38183-03-8 | 254.24 | 25 MG
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). It displays therapeutic efficacy toward various neurological diseases.
- Protects primary cortical neurons and locus coeruleus neurons from Aβ-induced toxicity
- Promotes dendritic growth and synaptogenesis
- Prevents synaptic loss and memory deficits in an Alzheimer's Disease model
- Activates TrkB in the brain
- Inhibits kainic acid-induced toxicity
- Decreases infarct volumes in stroke
- Neuroprotective in a Parkinson disease model
TARGETMOL CHEMICALS INC Acacetin 50MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, exhibiting antinociceptive, anti-inflammatory, and antioxidant activities in different research models. Purity 98%
Apexbio Technology LLC AST 487 630124-46-8 5mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
TARGETMOL CHEMICALS INC Luteolin 7-diglucuronide 5MG
Also available in 1 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Luteolin 7-diglucuronide, the major flavonoid isolated from Verbena officinalis and Aloysia triphylla. Purity 98.44%
TARGETMOL CHEMICALS INC Catechin 10MG
Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. (-)-Catechin ((-)-Cianidanol), an isomer of catechin, inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 uM. Purity 98.06%
Medchemexpress LLC HY-N0014 100mg Medchemexpress, Icariin CAS:489-32-7 Purity:>98%
Medchemexpress, HY-N0014 100mg Icariin CAS:489-32-7 Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC 50 s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Naringin 10236-47-2 200mg
Naringin (CAS 10236-47-2) is a flavanone glycoside predominantly isolated from the fruit of Citrus paradisi Macfadyen (grapefruit) It is recognized for modulating various cellular pathways including inhibition of oxidative stress and inflammation through interaction with NF- B and MAPK signaling cascades Naringin has demonstrated antioxidative anti-inflammatory and potential anti-carcinogenic properties in cellular and animal models Widely used in biomedical research it serves as a tool compound for investigating mechanisms underlying chronic diseases metabolic syndromes and the modulation of drug-metabolizing enzymes For optimal stability it should be stored in a tightly sealed container under cool dry conditions
Medchemexpress LLC Acacetin, 5,7-dihydroxy-4'-methoxyflavone | 480-44-4 | 284.26 | 100 MG
Acacetin is an orally active flavonoid derived from *Dendranthema morifolium*. It acts by docking in the ATP binding pocket of PI3Kγ. Acacetin induces cell cycle arrest, apoptosis, and autophagy in cancer cells.
- Possesses potent anti-cancer and anti-inflammatory activity.
- Has potential for research into pain-related diseases.
- Decreases cancer cell viabilities in a dose-dependent manner.
- Induces apoptosis and autophagy.
Apexbio Technology LLC 7,8-Dihydroxyflavone 38183-03-8 10mM (in 1mL DMSO)
7 8-Dihydroxyflavone (CAS 38183-03-8) is a small-molecule compound that acts as a selective agonist of the tropomyosin receptor kinase B (TrkB) By mimicking the action of brain-derived neurotrophic factor (BDNF) it activates TrkB-mediated signaling pathways resulting in enhanced neuronal survival and modulation of synaptic plasticity 7 8-Dihydroxyflavone is widely utilized in experimental studies on neurodegenerative diseases and neurological disorders serving as a valuable tool for investigating neurotrophic signaling mechanisms and the development of potential therapeutics for central nervous system pathologies
Medchemexpress LLC Acacetin | 480-44-4 | 284.26 | 50 MG
Acacetin is an orally active flavonoid, 5,7-Dihydroxy-4'-methoxyflavone, isolated from Dendranthema morifolium. It acts as a PI3Kγ inhibitor, inducing cell cycle arrest, apoptosis, and autophagy in various cancer cells. This compound exhibits potent anti-cancer and anti-inflammatory activities, making it a promising candidate for pain-related disease research.
- Orally active flavonoid
- Derived from Dendranthema morifolium
- Docks in ATP binding pocket of PI3Kγ
- Causes cell cycle arrest in cancer cells
- Induces apoptosis and autophagy in cancer cells
- Potent anti-cancer activity
- Potent anti-inflammatory activity
- Potential for pain-related diseases research
- Suppresses microglial activation in neuroinflammation models
- Reduces neuronal cell death in ischemia models
- Decreases visceral and inflammatory nociception
Selleck Chemical LLC Luteolin S2320-1g
Luteolin (Luteoline Luteolol Digitoflavone) is a flavonoid found in Terminalia chebula which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15 0 M 6 4 M 13 9 M 11 1 M and 9 5 M respectively