Flavonoids
AdipoGen Luteolin
Chemical. CAS 491-70-3. Formula C15H10O6. MW 286.2. Synthetic. Anticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase 15-LOX inhibitor. IL-6 production inhibitor. Fatty acid synthase FAS inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-gamma inhibitor. Neuroprotective. Monoamine transporter activator. Inhibitor of phosphodiesterases 1-5 PDE1-5. PKCepsilon and Src kinase inhibitor. HDAC inhibitor. Autophagy modulator Phosphatidylinositol 3-kinase PI3K / Akt signaling inhibitor. p90 ribosomal S6 kinase RSK1/RSK2 kinase activity inhibitor.
Cayman Chemical ApIgenIn 7OGlucuronIdehyd 10mg
A flavonoid with diverse biological activities; inhibits MMP-3, MMP-8, MMP-9, and MMP-13 (IC50s = 12.87, 22.39, 17.52, and 0.27 μM, respectively); inhibits PTP1B, AChE, and aldose reductase (IC50s = 7.14, 62.96, and 107.1 µM, respectively; inhibits LPS-induced production of nitric oxide, PGE2, and TNF-α in RAW 264.7 cells at 100 µM; improves survival in a mouse model of septic shock induced by LPS at 5 or 10 mg/kg
Medchemexpress LLC Luteolin-4'-O-glucoside | 6920-38-3 | 1 MG
Luteolin-4'-O-glucoside is an IL-5 inhibitor with an IC50 of 3.7 μM. It resists hyperuricemia and acute gouty arthritis activity and also exhibits anticancer activity. This compound has a molecular weight of 448.38, a chemical formula of C21H20O11, and appears as an off-white to yellow solid. It is classified as a flavonoid and phenol, and is initially sourced from plants such as Punicaceae Punica granatum L. This product is intended for research use only.
- IL-5 inhibitor with an IC50 of 3.7 μM
- Resists hyperuricemia and acute gouty arthritis activity
- Exhibits anticancer activity
- Molecular weight of 448.38
- Chemical formula C21H20O11
- Solid appearance, off-white to yellow color
- 99.36% purity
- Cytotoxic activity against NCI-H929, U266, and OPM2 cell lines
- Derived from plants like Punicaceae Punica granatum L.
- For research use only
Cayman Chemical Cel-Based asy ApIgenIn 100uL
Source Recombinant MERS-CoV C-Terminal His-tagged nucleocapsid protein expressed in insect cells Amino acids 1-413 (full length) MW 46.51 kDa
Cayman Chemical ApIgenIn 7-glucosIde 10mg
A flavonoid with anti-inflammatory and anxiolytic activities; inhibits LPS-induced nitric oxide production in RAW 264.7 cells from 0.16-10 μM; reduces pulmonary edema and lung inflammation in a mouse model of LPS-induced acute lung injury at 10 mg/kg; increases the number of entries and the time spent in the open arms of the elevated plus maze in rats
Medchemexpress LLC Luteolin-3-O-beta-D-glucuronide | 53527-42-7 | 98.9% | 462.36 g·mol⁻¹ | C21H18O12 | 10 MG
Luteolin-3-O-beta-D-glucuronide is a flavonoid metabolite of luteolin used as a research reagent and analytical standard in biochemical and pharmacological studies. The compound is supplied as a high-purity solid for use in metabolism, enzymology, and analytical method development.
- High purity (~98.9%) suitable for analytical and biological assays.
- Molecular formula C21H18O12 and molecular weight 462.36 g·mol⁻¹.
- Identified by CAS number 53527-42-7 for unambiguous chemical tracking.
- Available in small milligram quantities for assay development and reference use.
- Reported as a luteolin metabolite present in plant sources such as Rosmarinus officinalis.
Cayman Chemical LuteolIn 7-O-GlucuronIde 5mg
A flavonoid with antioxidant, enzyme inhibitory, and anti-inflammatory properties; scavenges DPPH radicals in a cell-free assay (IC50 = 80.6 μM); inhibits porcine α-amylase and yeast α-glucosidase in vitro (IC50s = 61.5 and 14.7 μM, respectively); inhibits rat aldose reductase in vitro (IC50 = 0.7 μM) and sorbitol accumulation in isolated rat lens at 5 μg/ml; inhibits LPS-induced cytokine release from RAW 264.7 macrophages in a dose-dependent manner
Medchemexpress LLC Apigenin | 520-36-5 | 1 ML
Apigenin, also known as 4',5,7-Trihydroxyflavone, functions as a competitive inhibitor of CYP2C9 with a Ki of 2 μM. This compound has been observed to inhibit cell proliferation and suppress clone formation in various cell lines, making it suitable for research applications exploring its biological activity.
- Competitive CYP2C9 inhibitor
- Inhibits cell proliferation
- Suppresses clone formation of cells
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 5 MG
Luteolin 7-O-glucuronide is a compound that inhibits Matrix Metalloproteinases (MMP) activities, with specific IC50 values for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13. It also demonstrates biological activity by inhibiting NO production and the mRNA expression of various inflammatory mediators, as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In vivo studies suggest it can improve depression-like and stress coping behaviors in sleep-deprived mice models.
- Inhibits matrix metalloproteinases (MMPs) activities
- Inhibits NO production in LPS-stimulated RAW 264.7 macrophages
- Reduces mRNA expression of inflammatory mediators
- Suppresses NF-κB, p38, and JNK activation
- Improves depression-like and stress coping behaviors in sleep deprivation models
- Decreases immobility time and plasma corticosterone levels
- Enhances BDNF mRNA expression in the hippocampus
Cayman Chemical ApIgenIn 7-glucosIde 25mg
A flavonoid with anti-inflammatory and anxiolytic activities; inhibits LPS-induced nitric oxide production in RAW 264.7 cells from 0.16-10 μM; reduces pulmonary edema and lung inflammation in a mouse model of LPS-induced acute lung injury at 10 mg/kg; increases the number of entries and the time spent in the open arms of the elevated plus maze in rats
Medchemexpress LLC (-)-Epicatechin gallate (standard) | 1257-08-5 | 442.37 | 1 MG
(-)-Epicatechin gallate (Standard) is the analytical standard of (-)-Epicatechin gallate. This product is intended for research and analytical applications. It inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM, and is a GLUT1 and GLUT5 inhibitor, decreasing cell growth of GLUT5-expressing hxt 0 yeast cells.
- Targets: COX, autophagy, virus protease, GLUT
- Research areas: Infection, cancer
- Structural classification: Flavonoids, flavanols, phenols, polyphenols
- Source classification: *Camellia sinensis* (L.) O. Ktze. plants, Theaceae
Medchemexpress LLC Luteolin 5-O-glucoside | 20344-46-1 | 448.38 | 25 MG
Luteolin 5-O-glucoside is a major flavonoid found in *Cirsium maackii* that exhibits anti-inflammatory activity. It is effective in inhibiting LPS-induced NO production and t-BHP-induced ROS generation, and it also suppresses the expression of iNOS and COX-2 in macrophages.
- Inhibits LPS-induced NO production
- Suppresses expression of iNOS and COX-2
- Inhibits t-BHP-induced ROS generation
- Appears as a light yellow to yellow solid
Medchemexpress LLC Luteolin monohydrate | 6113-16-2 | MFCD00017309 | 99.1% | 304.25 g/mol | C15H12O7 | 250 MG
Luteolin monohydrate is the monohydrate form of luteolin, a naturally occurring flavonoid used in life-science research. It is reported to act as an Nrf2 pathway modulator and shows anti-inflammatory and anticancer activity in cellular studies. It is supplied as a solid and provided in small research quantities for biochemical assays and mechanistic investigations.
- Monohydrate form of luteolin
- Reported Nrf2 inhibitor and bioactive flavonoid
- High purity (99.13%)
- Available in small research quantities, e.g., 250 mg
- Storage: 4°C, sealed, away from moisture; in solution: -80°C (6 months)
Abcam Apigenin, Anticancer agent, 10MG
MW 270.24 Da, Purity >98%. Plant flavone. Antioxidant, anti-inflammatory and anticancer properties. Effects a wide range of molecular targets including caspases, fatty acid synthase, topoisomerase and nuclear factor-κB.
The product is subject to the following: Abcam Restricted Use Statement