Linear 1 3-diarylpropanoids
Medchemexpress LLC 2-propen-1-one, 1,3-diphenyl- | 94-41-7 | 100.0% | 1 ML
Chalcone (2-Propen-1-one, 1,3-diphenyl-) is an α,β-unsaturated ketone used as a synthetic building block and research reagent. It is supplied as a solid or as a prepared 10 mM solution in DMSO, 1 ML, for screening and synthesis applications.
- Offered as solid and as 10 mM solution in DMSO, 1 ML.
- High purity (99.98% by HPLC) suitable for research use.
- Commonly used for synthesis of chalcone derivatives and biological screening.
- Provided with certificate of analysis documenting identity and purity.
Medchemexpress LLC Chalcone | 94-41-7 | 100.0% | 50 MG
Chalcone is the parent α,β-unsaturated ketone scaffold used widely as a small-molecule research chemical and synthetic building block. Provided as a high-purity solid, it is used in medicinal chemistry, biochemical assays, and the synthesis of chalcone derivatives. Typical identifiers: CAS 94-41-7; formula C15H12O; molecular weight 208.25 g/mol.
- High purity suitable for research use.
- Useful building block for synthesis of bioactive derivatives.
- Compatible with DMSO; available as solution for screening.
- Supplied with certificate of analysis and safety data for quality and safety.
- Available in small-scale quantities for discovery research.
Medchemexpress LLC AKT-IN-6 | 1430056-54-4 | 99.1% | 389.43 | 1 ML
AKT-IN-6 is a potent Akt inhibitor that targets Akt1, Akt2, and Akt3 with IC50s below 500 nM. Akt is a central node in cell signaling, and its aberrant activation is linked to various complex diseases, including type-2 diabetes and cancer.
- Potent Akt inhibitor
- Targets Akt1, Akt2, and Akt3
- Suitable for research applications
Medchemexpress LLC Xanthohumol | 6754-58-1 | 99.9% | 354.40 | 5 MG
Xanthohumol is a principal flavonoid isolated from hops. It inhibits diacylglycerol acetyltransferase (DGAT), COX-1, and COX-2, and demonstrates anti-cancer, anti-angiogenic, and antiviral activities against viruses like bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2, and cytomegalovirus (CMV).
- Derived from hops
- Inhibits diacylglycerol acetyltransferase (DGAT)
- Inhibits COX-1 and COX-2
- Exhibits anti-cancer activity
- Exhibits anti-angiogenic activity
- Possesses antiviral activity
- Classified as a flavonoid, chalcone, phenol, and polyphenol
Medchemexpress LLC Naringenin | 480-41-1 | 99.3% | 272.25 | 5 MG
Naringenin is the predominant flavanone found in Citrus reticulata Blanco. It exhibits strong anti-inflammatory and antioxidant activities, and also possesses anti-dengue virus (DENV) activity.
- Inhibits proliferation and induces apoptosis in HepG2 cells
- Reduces cell viability and increases DNA fragmentation in A431 cells
- Reduces plasma and liver triglyceride and cholesterol levels
- Lowers adiposity and triglyceride content
- Increases hepatic PPARα protein expression and enhances CPT-1 and UCP2 expression
- Boosts hepatic fatty acid oxidation and prevents sterol regulatory element-binding protein 1c-mediated lipogenesis
- Inhibits TNF-α-induced VSMC proliferation and migration
Medchemexpress LLC Xanthohumol C | 189299-05-6 | 99.2% | 352.38 | C21H20O5 | 10 MG
Xanthohumol C is a prenylchalcone natural product isolated from the hops plant Humulus lupulus. It is used in research and has reported cytotoxic and antiproliferative activity in human cancer cell lines.
- Chemical formula C21H20O5.
- Molecular weight 352.38.
- Purity 99.2%.
- Reported cytotoxicity against HeLa cells (IC50 12.5 μM).
- Antiproliferative activity against MCF7 cells (IC50 15.7 μM for 2 days, 6.87 μM for 4 days).
- Supplied as a 10 MG research quantity.
Medchemexpress LLC Xanthohumol | 6754-58-1 | MFCD00210576 | 354.40 | 500 MG
Xanthohumol is one of the principal flavonoids isolated from hops, known for its inhibitory effects on diacylglycerol acetyltransferase (DGAT), COX-1, and COX-2. It demonstrates anti-cancer, anti-angiogenic, and antiviral activities against various viruses including bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2, and cytomegalovirus (CMV). This product is intended for research use only.
- Inhibitor of DGAT, COX-1, and COX-2
- Exhibits anti-cancer activity
- Possesses anti-angiogenic activity
- Shows antiviral activity against BVDV, rhinovirus, HSV-1, HSV-2, and CMV
- Appears as a yellow to orange solid
Medchemexpress LLC Naringenin trimethyl ether | 38302-15-7 | 1 MG
Naringenin trimethyl ether is a constituent of twigs and leaves of Aglaia duperreana. It is known for its significant molluscicidal activity, demonstrating an LC50 of 3.9 μg/mL for P. canaliculata. This compound is intended for research use only.
- Constituent of twigs and leaves of Aglaia duperreana
- Exhibits significant molluscicidal activity
- LC50 of 3.9 μg/mL for P. canaliculata
Medchemexpress LLC Phlorizin | 60-81-1 | MFCD00006652 | ≥98% | 436.43 | 1 G
Phlorizin is a biochemical reagent that acts as a non-selective SGLT inhibitor (hSGLT1 Ki: 300 nM, hSGLT2 Ki: 39 nM) and a Na+/K+-ATPase inhibitor. It is suitable for use as a biological material or organic compound in life science research.
- Non-selective SGLT inhibitor
- Na+/K+-ATPase inhibitor
- Classification: Flavonoids, Phenols, Polyphenols, Dihydrochalcones
- Source: Malus pumila Mill. (Rosaceae), Plants
- Targets: SGLT, Na+/K+ ATPase
- Research areas: Metabolic disease
Medchemexpress LLC Phlorizin | 60-81-1 | 99.9% | 436.41 | 5 G
Phlorizin is a non-selective SGLT inhibitor that acts on hSGLT1 and hSGLT2. It also functions as a Na+/K+-ATPase inhibitor.
- Non-selective SGLT inhibitor.
- Inhibits hSGLT1 and hSGLT2.
- Na+/K+-ATPase inhibitor.
- Decreases blood glucose levels.
- Prevents nerve fiber decrease and retinal abnormalities.
Medchemexpress LLC Phloretin | 60-82-2 | 99.92% | 274.27 | 50 G
Phloretin is a flavonoid extracted from *Malus pumila Mill.* that possesses anti-inflammatory activities. It is also a specific, competitive, and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 and Human erythrocyte GLUT1 with IC50 values of 49 μM and 61 μM, respectively. It has potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation.
- Possesses anti-inflammatory activities
- Inhibits SGLT1 and SGLT2
- Inhibits Yeast-made GLUT1 and Human erythrocyte GLUT1
- Potential for treating rheumatoid arthritis and allergic airway inflammation
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 5 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent. It also possesses antioxidant and anti-inflammatory activities, and can improve adipocyte functions. It inhibits histamine release from rat peritoneal mast cells.
- Anti-allergic agent: Inhibits histamine release from mast cells and reduces ear-swelling in allergic mice.
- Antioxidant activity: Demonstrated antioxidant properties.
- Anti-inflammatory activity: Inhibits production of TNF-alpha, MCP-1, and nitric oxide by LPS-stimulated macrophages.
- Adipocyte function improvement: Enhances adiponectin production and stimulates PPARγ activity.
- High purity: 98.87%.
- Appearance: Solid, light yellow to yellow.
- Molecular weight: 272.26.
- Chemical formula: C15H12O5.
- Initial source: Plants (Solanaceae, *Solanum lycopersicum L.*).
Medchemexpress LLC 4'-Hydroxychalcone | 2657-25-2 | 1 ML
4'-Hydroxychalcone is a chalcone isolated from licorice root with hepatoprotective activity. It inhibits TNFa-induced NF-κB activation via proteasome inhibition. It also induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.
- Isolated from licorice root
- Exhibits hepatoprotective activity
- Inhibits TNFa-induced NF-κB activation through proteasome inhibition
- Induces rapid potassium release from mitochondrial vesicles
- Causes deterioration of respiratory control and oxidative phosphorylation
- Affects cancer cell viability
Medchemexpress LLC Butyl diphenyl phosphate | 2752-95-6 | MFCD00411621 | 306.29 g/mol | C16H19O4P | 50 MG
Butyl diphenyl phosphate is an organophosphate compound used primarily as a flame retardant and a plastic additive. This listing is for research-grade reagent quantities supplied with documented chemical identifiers; storage and analytical details are provided in the Certificate of Analysis.