Macrolide lactams
Medchemexpress LLC FK 3311 | 116686-15-8 | MFCD00876455 | 98.7% | C15H13F2NO4S | 50 MG
FK 3311, also known as COX-2 Inhibitor V, is a selective inhibitor of COX-2 with anti-inflammatory properties. It is intended for research use only.
- Targets COX-2
- Exhibits anti-inflammatory activity by inhibiting adjuvant-induced arthritis
- Demonstrates analgesic effects in the acetic acid-induced writhing assay
- Improves L-PVR, CO, PaO(2), and WDR in a canine model of pulmonary ischemia-reperfusion injury
- Reduces histological tissue edema and PMN infiltration
- Lowers serum TxB(2) levels and improves survival rate in pulmonary ischemia-reperfusion injury
- Improves survival rates and lowers serum GOT/GPT levels in liver transplantation with ischemia-reperfusion injury
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 100mg
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
Medchemexpress LLC N-(1-oxoheptyl)-D-gamma-glutamyl-(6R)-6-carboxy-L-lysyl-D-alanine | 79335-75-4 | 99.9% | 502.57 g/mol | C22H38N4O9 | 25mg
FK-565 is a nucleotide oligomerization domain-1 (NOD1) ligand FK-565 induces murine model with arteritis[1]
Medchemexpress LLC Fk 453 (compound 1d) | 121524-18-3 | 99.2% | 375.46 g·mol⁻¹ | C23H25N3O2 | 5 MG
FK 453 (compound 1d) is a potent and selective adenosine A1 receptor antagonist (IC50 17.2 nM) intended for research use. It is a non-xanthine small molecule used in pharmacological studies to probe A1 receptor function and ligand interactions.
- Potent adenosine A1 antagonist (IC50 17.2 nM).
- High purity 99.2%.
- Molecular weight 375.46 g·mol⁻¹.
- Chemical formula C23H25N3O2.
- Supplied as 5 mg solid for laboratory research.
- Suitable for in vitro pharmacology and receptor binding assays.
Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | 99.9% | 822.03 | 100 MG
Tacrolimus monohydrate | 109581-93-3 | 99.9% | 822.03 | 100 MG
Selleck Chemical LLC FK-3311 S2595-5mg
FK-3311 (COX-2 Inhibitor V) is a selective cell-permeable and orally available inhibitor of cyclooxygenase-2 (COX-2) with antiinflammatory FK-3311 has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2
![Alkali Scientific FK 506 [Tacrolimus] [Fujimycin], 25 Mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000661159.jpg-250.jpg)
Alkali Scientific FK 506 [Tacrolimus] [Fujimycin], 25 Mg
Tacrolimus (FK 506, also known as Fujimycin) is a potent immunosuppressant used in laboratory research to study immune response modulation. This 25mg laboratory-grade supply is ideal for cell culture experiments focused on T-cell activation inhibition. Tacrolimus works by binding to immunophilin FKBP-12, forming a complex that inhibits calcineurin, a key enzyme in T-cell signaling. This process suppresses immune cell activation, making tacrolimus a valuable tool for transplant immunology and autoimmune disease research. It is widely used to explore the effectiveness of immunosuppressive treatments and to better understand the molecular mechanisms of immune response.
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 1g
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
Medchemexpress LLC E/Z-FK-506 26,28-allylic ester rearrangement impurity | 131944-48-4 | >90.0% | 804.02 | C44H69NO12 | 10 MG
(E/Z)-FK-506 26,28-allylic ester rearrangement impurity (FK506-A) is an impurity of tacrolimus used as a reference standard for analytical and stability studies. It is intended for research and analytical applications to identify, quantify, and qualify impurity profiles; consult the certificate of analysis for storage and handling details.
- Reference impurity of tacrolimus for analytical method development.
- Suitable for impurity identification, reporting, and qualification studies.
- High-purity material for reliable chromatographic and mass spectrometric analysis (>90.0%).
- Supplied as a solid for laboratory use; consult the certificate of analysis for storage instructions.
- Molecular formula C44H69NO12 and molecular weight 804.02 for compound identification.
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 10mM (in 1mL DMSO), CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Selleck Chemical LLC Tacrolimus monohydrate
Tacrolimus monohydrate (Tacrolimus FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) This inhibition blocks calcium-dependent processes including interleukin-2 gene transcription nitric oxide synthase activation cell degranulation and apoptosis and also has immunosuppressive neuroregenerative and neuroprotective properties