Macrolide lactams
TARGETMOL CHEMICALS INC FK-453 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. FK-453 is a potent antagonist of non-xanthine adenosine A1 receptor with diuretic and renal vasodilatory activity. purity: 99%
Medchemexpress LLC N-(1-oxoheptyl)-D-gamma-glutamyl-(6R)-6-carboxy-L-lysyl-D-alanine | 79335-75-4 | 99.9% | 502.57 g/mol | C22H38N4O9 | 25mg
FK-565 is a nucleotide oligomerization domain-1 (NOD1) ligand FK-565 induces murine model with arteritis[1]
Medchemexpress LLC D-alanine, N-((R)-6-carboxy-N2-(N-(1-oxoheptyl)-D-gamma-glutamyl)-L-lysyl)- | 79335-75-4 | ≥98.0% | 502.57 g/mol | C22H38N4O9 | 5mg
FK-565 is a nucleotide oligomerization domain-1 (NOD1) ligand FK-565 induces murine model with arteritis[1]
AdipoGen Ascomycin high purity
Chemical. CAS 104987-12-4. Formula C43H69NO12. MW 792. Isolated from Streptomyces sp. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin protein phosphatase 2B PP2B. Suppresses the production of T helper type 1 Th1 interferon and IL-2 and Th2 IL-4 and IL-10 cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant antiepileptic.
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 10mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Medchemexpress LLC E/Z-FK-506 26,28-allylic ester rearrangement impurity | 131944-48-4 | >90.0% | 804.02 | C44H69NO12 | 10 MG
(E/Z)-FK-506 26,28-allylic ester rearrangement impurity (FK506-A) is an impurity of tacrolimus used as a reference standard for analytical and stability studies. It is intended for research and analytical applications to identify, quantify, and qualify impurity profiles; consult the certificate of analysis for storage and handling details.
- Reference impurity of tacrolimus for analytical method development.
- Suitable for impurity identification, reporting, and qualification studies.
- High-purity material for reliable chromatographic and mass spectrometric analysis (>90.0%).
- Supplied as a solid for laboratory use; consult the certificate of analysis for storage instructions.
- Molecular formula C44H69NO12 and molecular weight 804.02 for compound identification.
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 500mg
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | MFCD11045918 | 99.9% | 822.03 g·mol⁻¹ | C44H71NO13 | 5 MG
Tacrolimus monohydrate is a macrocyclic lactone immunosuppressant reagent that binds FK506 binding protein (FKBP) and inhibits calcineurin phosphatase, suppressing T-cell signaling and IL-2 transcription for in vitro immunology and biochemical studies.
- High purity suitable for research applications.
- Molecular formula C44H71NO13; molecular weight 822.03 g·mol⁻¹.
- CAS number 109581-93-3 for unambiguous identification.
- Store protected from light at 4°C; in solution store at -80°C for long-term stability.
- Commonly used in assays targeting calcineurin and FKBP-mediated pathways.
![Medchemexpress LLC (+)-(R)-[(E)-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acryloyl]-2-piperidineethanol | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244110.png-250.jpg)
Medchemexpress LLC (+)-(R)-[(E)-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acryloyl]-2-piperidineethanol | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 50 MG
FK 453 is a non-xanthine adenosine A1 receptor antagonist (compound 1d) used in pharmacological research. It is reported as potent and selective, with an IC50 of 17.2 nM. The compound has chemical formula C23H25N3O2, molecular weight 375.46, and reported purity 99.20%.
- Potent and selective A1 receptor antagonist (IC50 17.2 nM).
- High reported purity suitable for research use (99.2%).
- Chemical formula C23H25N3O2 and molecular weight 375.46.
- Available in small research quantities, for example 50 mg.
- Supplied with supporting analytical data such as COA, HPLC, and LCMS.
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 1g
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression