Benzenesulfonyl compounds
Enzo Life Sciences Sulindac sulfone (5mg). CAS: 59864-04-9
Induces apoptosis but does not inhibit cyclooxygenase. Inhibits growth and induces apoptosis in human cancer cell lines. Metabolite of Sulindac (ALX-430-105). Alternative name: Z-5-Fluoro-2-methyl-1-[p-(methyl-sulfonyl)benzylidene]indene-3-acetic acid. Purity: ≥94% (HPLC). Solubility: Soluble in DMSO (>25mg/ml) or 100% ethanol (3mg/ml, warm). Long Term Storage: Ambient.
Chem-Impex International, Inc. 4-Fluorophenyl methyl sulfone | MFCD00039753 | 5G
4-Fluorophenyl methyl sulfone, MFCD00039753, 5G
eMolecules 603139-19-1 | Medchem Express | Odanacatib | 5mg | 446255431 | HY-10042 | MFCD11042419 | 525.56 | C25H27F4N3O3S
Medchem Express | Odanacatib | 5mg | 446255431 | HY-10042 | 603139-19-1 | MFCD11042419 | 525.560 | C25H27F4N3O3S
eMolecules AstaTech / 135-TRI(4-HYDROXYPHENYL)BENZENE / 0.25g / 454895741 / S12188 / 95.000 / 15797-52-1 / MFCD01321328 / 354.405 / C24H18O3
AstaTech / 135-TRI(4-HYDROXYPHENYL)BENZENE / 0.25g / 454895741 / S12188 / 95.000 / 15797-52-1 / MFCD01321328 / 354.405 / C24H18O3
![Medchemexpress LLC 4-[1-(4-cyclohexylphenyl)-3-(3-methanesulfonylphenyl)ureidomethyl]-N-(2H-tetrazol-5-yl)benzamide | 307986-98-7 | 98.4% | 573.67 g·mol⁻1 | C29H31N7O4S | 50MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000236275.png-250.jpg)
Medchemexpress LLC 4-[1-(4-cyclohexylphenyl)-3-(3-methanesulfonylphenyl)ureidomethyl]-N-(2H-tetrazol-5-yl)benzamide | 307986-98-7 | 98.4% | 573.67 g·mol⁻1 | C29H31N7O4S | 50MG
NNC-0640 is a small-molecule negative allosteric modulator (NAM) of the human glucagon receptor (GCGR) used for biochemical and preclinical research. It has an IC50 of 69.2 nM against human GCGR, a molecular weight of 573.67 g·mol⁻1, formula C29H31N7O4S, and supplier-reported purity >98%.
- Negative allosteric modulator of human glucagon receptor with IC50 69.2 nM.
- High purity suitable for biochemical and preclinical research (>98%).
- Characterized molecular weight 573.67 g·mol⁻1 and formula C29H31N7O4S.
- Available as solid and as a 10 mM solution in DMSO for assay use.
- Intended for research use only; not for human or clinical use.
eMolecules 3-(Methylsulfonyl)benzyl alcohol | 220798-39-0 | MFCD15527275 | 1g
Combi-Blocks | 3-(Methylsulfonyl)benzyl alcohol | 1g | 205413511 | ST-7064 | 96.000 | 220798-39-0 | MFCD15527275 | 186.230 | C8H10O3S
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Medchemexpress LLC USP7-IN-3 | 2202738-42-7 | 99.1% | 568.59 | 10 MG
USP7-IN-3 (Compound 5) is an effective and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7). It can be used for research on acute lymphoblastic leukemia. It can also reduce MDM2 levels in HCT116 cells and upregulate p53 expression, indicating that it activates the p53 signaling pathway through USP7 inhibition. USP7-IN-3 can inhibit the proliferation of RS4;11 cells, demonstrating its high selectivity and efficacy against acute lymphoblastic leukemia cells.
- Effective and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).
- Can be used for research on acute lymphoblastic leukemia.
- Reduces MDM2 levels and upregulates p53 expression in HCT116 cells, activating the p53 signaling pathway through USP7 inhibition.
- Inhibits proliferation of RS4;11 cells.
![Medchemexpress LLC 7H-pyrazolo[4,3-d]pyrimidin-7-one, 3-[4-(aminomethyl)phenyl]-2-methyl-6-(piperidin-4-yl)methyl... | 2202738-42-7 | MFCD31813656 | 99.1% | 568.59 g·mol⁻¹ | C29H31F3N6O3 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000263603.png-250.jpg)
Medchemexpress LLC 7H-pyrazolo[4,3-d]pyrimidin-7-one, 3-[4-(aminomethyl)phenyl]-2-methyl-6-(piperidin-4-yl)methyl... | 2202738-42-7 | MFCD31813656 | 99.1% | 568.59 g·mol⁻¹ | C29H31F3N6O3 | 5 MG
USP7-IN-3 is a selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7) used for biochemical and cell-based research, including studies of p53/MDM2 signaling and acute lymphoblastic leukemia. It is supplied as a white to off-white solid with characterized physicochemical and biological properties for in vitro and in vivo use.
- Selective allosteric inhibition of USP7.
- Reduces MDM2 levels and increases p53 expression in cell assays.
- Inhibits proliferation of RS4;11 acute lymphoblastic leukemia cells.
- High purity (~99.1%) with defined molecular weight and formula.
- Soluble in DMSO; in vivo formulation protocols documented.
- Stable as powder at -20°C; solution storage conditions specified.
Medchemexpress LLC 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole benzenesulfonate | 1280210-80-1 | 98.8% | 10 G
2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole benzenesulfonate is a drug intermediate for the synthesis of various active compounds.
- Target drug intermediate
- Molecular formula: C12H15N3O5S2
- Molecular weight: 345.40
- Appearance: White to light yellow solid
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Purity: 98.8%
Accela Chembio Inc 4-fluorophenyl Methyl Sulfone | 100g | 455-15-2 | MFCD00039753 | 97+% | Shelf Life: 1260 Days | Regular
4-fluorophenyl Methyl Sulfone | 100g | 455-15-2 | MFCD00039753 | 97+% | Shelf Life: 1260 Days | Regular
Medchemexpress LLC Stattic 10 Mm 1 Ml In Dmso | HY-13818-10MM 1ML IN DMSO
Stattic 10 Mm 1 Ml In Dmso
![Medchemexpress LLC 4-[[4-cyclohexyl-N-[(3-methylsulfonylphenyl)carbamoyl]anilino]methyl]-N-(2H-tetrazol-5-yl)benzamide | 307986-98-7 | 98.4% | 573.67 g/mol | C29H31N7O4S | 100MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000236147.png-250.jpg)
Medchemexpress LLC 4-[[4-cyclohexyl-N-[(3-methylsulfonylphenyl)carbamoyl]anilino]methyl]-N-(2H-tetrazol-5-yl)benzamide | 307986-98-7 | 98.4% | 573.67 g/mol | C29H31N7O4S | 100MG
NNC-0640 is a small-molecule negative allosteric modulator (NAM) of the human glucagon receptor (GCGR) characterized for preclinical research. It shows an IC50 of 69.2 nM against human GCGR and is supplied at high purity for biochemical and cellular studies. Intended for research use only; not for human or veterinary use.
- Negative allosteric modulator of human glucagon receptor (GCGR).
- IC50 = 69.2 nM in human GCGR assays.
- High purity (98.4%) suitable for biochemical and cellular studies.
- Molecular weight 573.67 g/mol.
- Provided as a 100 mg package for laboratory use.
- Intended for research use only; not for human or veterinary use.
Medchemexpress LLC HY-13453 10mg Medchemexpress, BAY 11-7082 CAS:19542-67-7 Purity:>98%
Medchemexpress, HY-13453 10mg BAY 11-7082 CAS:19542-67-7 BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells[2][3][4][5]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.