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Filtered Search Results
Medchemexpress LLC Bifluranol (BX341) | 34633-34-6 | 292.32 | 50 MG
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Bifluranol (BX341) is an anti-androgen compound intended for research use only. Studies have demonstrated its absorption, distribution, and excretion profiles in various animal models, including mice, rats, ferrets, and dogs. It is readily absorbed orally, but blood concentrations remain low due to significant hepatic uptake and biliary excretion.
- Acts as an androgen receptor inhibitor.
- Readily absorbed after oral administration.
- Exhibits low blood concentrations due to hepatic uptake and biliary excretion.
- Suitable for research applications.
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Medchemexpress LLC Nelociguat (BAY60-4552) | 625115-52-8 | 99.7% | C19H17FN8O2 | 50 MG
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Nelociguat (BAY60-4552) is a light yellow to yellow solid compound with a molecular weight of 408.39. Intended for research use only, it acts as a stimulator of nitric oxide sensitive soluble guanylate cyclase.
- Metabolite of riociguat, formed via cytochrome P450 isoenzymes.
- Decreases urine output and improves survival in spontaneously hypertensive stroke-prone rats.
- Reduces microalbuminuria and attenuates the rise in mean arterial pressure at higher doses.
- Dose-dependently decreased urine output during a 7-week treatment.
- Combination therapy with vardenafil showed synergistic beneficial effects.
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Medchemexpress LLC Glycyl-Exatecan-d5 hydrochloride | 1883333-57-0 | 99.0% | 1 MG
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Glycyl-Exatecan-d5 hydrochloride is a deuterium-labeled derivative of Glycyl-Exatecan, which is itself a derivative of Exatecan. This compound functions as an anticancer agent, demonstrating significant antitumor activity. It is suitable for research related to various cancers, including solid tumors. It also serves as a tracer and an internal standard for quantitative analytical methods such as NMR, GC-MS, or LC-MS.
- Deuterium labeled compound
- Derivative of Exatecan
- Anticancer agent with significant antitumor activity
- Suitable for solid tumors research
- Functions as a tracer
- Used as an internal standard for quantitative analysis
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Medchemexpress LLC TC11 | 100823-03-8 | 99.6% | 10 MG
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TC11 is an MCL1 degrader and a Caspase-9 and CDK1 activator. It functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces the degradation of MCL1, leading to apoptotic death during prolonged mitotic arrest.
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Medchemexpress LLC KX-01-191 | 2211903-84-1 | 98.2% | 10 MG
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KX-01-191 (compound 5c′) is a tin-precursor.
- For research use only
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Medchemexpress LLC RORγt Inverse agonist 6 | 99.0% | 50 MG
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RORγt Inverse agonist 6 is a chemical compound acting as an antagonist. It is typically supplied with a high purity level.
- Acts as an antagonist.
- Has a high purity level.
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Medchemexpress LLC Abemaciclib metabolite M18 (hydrochloride) | 2704316-82-3 | 98.2% | 50 MG
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Abemaciclib metabolite M18 hydrochloride is a metabolite of Abemaciclib and functions as a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders. This product is for research use only, suitable for laboratory chemical applications and experienced personnel. It inhibits retinoblastoma (RB) protein phosphorylation, inducing cell cycle arrest, and can increase T-cell persistence and immunologic memory.
- Solid appearance
- Purity of 98.18%
- Molecular weight: 531.00
- Chemical formula: C25H29ClF2N8O
- Stable under recommended storage conditions
- Not classified as a hazardous substance or mixture
- Acts as a CDK inhibitor
- Exhibits antitumor activity
- Inhibits retinoblastoma (RB) protein phosphorylation
- Induces cell cycle arrest
- Can be used to design PROTAC CDK4/6 degrader
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Medchemexpress LLC RORγt Inverse agonist 6 | 1887161-80-9 | 99.0% | 100 MG
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RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. It suppresses IL-17A gene expression by IL-23 stimulation.
- RORγt inverse agonist.
- Used for studying Th17-driven autoimmune diseases.
- Suppresses IL-17A gene expression.
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Medchemexpress LLC EGFR-IN-11 | 2463200-44-2 | 98.8% | 50 MG
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EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 18 nM for triple mutant EGFRL858R/T790M/C797S. It significantly suppresses EGFR phosphorylation, induces apoptosis, and arrests the cell cycle at G0/G1.
- Suppresses EGFR phosphorylation
- Induces apoptosis
- Arrests cell cycle at G0/G1 phase
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Medchemexpress LLC Ars-1323-alkyne | 2436544-27-1 | 99.6% | 50 MG
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ARS-1323-alkyne is a covalent inhibitor probe that covalently binds to the Switch-II pocket (S-IIP) of the KRAS G12C mutant protein. ARS-1323-alkyne visualizes the covalent modification of KRAS G12C and quantitatively measures the binding efficiency of the inhibitor to the target. ARS-1323-alkyne can be used to validate the target occupancy of KRAS G12C inhibitors and the synergistic mechanism of combination therapy.
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Medchemexpress LLC Abemaciclib metabolite M2 | 1231930-57-6 | 99.8% | 10 MG
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Abemaciclib metabolite M2 is a potent CDK4 and CDK6 inhibitor, acting as a metabolite of Abemaciclib. It exhibits anti-cancer activity with IC50s of 1.2 nM for CDK4 and 1.3 nM for CDK6. This metabolite is the most prominent and active plasma metabolite found in humans. It shows plasma protein binding in rat, dog, and human between 83-92%.
- Acts as a potent CDK4 and CDK6 inhibitor
- Exhibits anti-cancer activity
- Most prominent and active plasma metabolite in humans
- Shows plasma protein binding in rat, dog, and human (83-92%)
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Medchemexpress LLC PT-2385 | 1672665-49-4 | 100.0% | 100 MG
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PT-2385 is a highly selective HIF-2α inhibitor, demonstrating a Ki of less than 50 nM. It acts as an antagonist specifically targeting HIF-2 over HIF-1, with no activity against HIF-1α. In preclinical studies, PT-2385 has shown significant in vivo activity by inhibiting the expression of HIF-2α regulated genes in a dose-dependent manner. This compound has also been observed to induce rapid, dose-dependent tumor regression in models using 786-O and A498 RCC cell lines, typically when administered at 30 or 100 mg/kg via oral gavage twice daily. Additionally, it contributes to reducing tumor-derived VEGFA protein levels, which in turn diminishes proliferation (Ki67) and angiogenesis (CD-31).
- Selective HIF-2α inhibitor
- Inactive against HIF-1α
- Inhibits HIF-2α regulated gene expression
- Induces tumor regression in preclinical models
- Reduces tumor proliferation and angiogenesis
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Medchemexpress LLC SCHAFTOSIDE 98% 10MG
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Schaftoside 98% 10mg 51938-32-0
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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NC3980879 CRIZOTINIB SOLUTION10MM 1ML
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eMolecules 351003-43-5 | 3,4,5-Trifluorobenzene-1-sulfonyl chloride | Ambeed | MFCD03094559 | 230.590 | C6H2ClF3O2S | 98.000 | Fc1cc(cc(F)c1F)S(Cl)(=O)=O | 5g | 595927253
3,4,5-Trifluorobenzene-1-sulfonyl chloride | Ambeed | 351003-43-5 | MFCD03094559 | 230.590 | C6H2ClF3O2S | 98.000 | Fc1cc(cc(F)c1F)S(Cl)(=O)=O | 5g | 595927253
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