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Filtered Search Results
Medchemexpress LLC Velsecorat | 1196509-60-0 | 99.8% | 606.62 | 100 MG
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Velsecorat (AZD7594) is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. It shows no effect on progesterone receptor, mineralocorticoid receptor, androgen receptor, ERα or ERβ (IC50, > 10 μM). This compound has anti-inflammatory activity and efficiently inhibits rat lung edema.
- Potent selective nonsteroidal glucocorticoid receptor modulator
- IC50 of 0.9 nM (Glucocorticoid receptor)
- Shows no effect on progesterone receptor, mineralocorticoid receptor, androgen receptor, ERα or ERβ (IC50, > 10 μM)
- Anti-inflammatory activity
- Efficiently inhibits rat lung edema
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Medchemexpress LLC Evixapodlin (GS-4224) | 2374856-75-2 | 98.1% | 691.61 g·mol⁻¹ | C34H36Cl2N8O4 | 5 MG
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Evixapodlin (GS-4224) is a potent small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction, reported with an IC50 of 0.213 nM and demonstrated anticancer and antiviral activity. It is supplied as a research-grade chemical for in vitro and preclinical studies.
- High potency PD-1/PD-L1 PPI inhibition (IC50 ~0.213 nM).
- Reported purity 98.1% by manufacturer.
- Soluble in DMSO at 50 mg/mL for in vitro use.
- Available in small milligram quantities and as DMSO solution for assay setup.
- Recommended storage conditions to preserve stability of powder and solutions.
- Suitable for biochemical and cellular immune checkpoint assays.
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Medchemexpress LLC GlyT1 Inhibitor 1 | 1820934-93-7 | 98.59% | 387.43 | 10 MG
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GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1. It also demonstrates antipsychotic activity and in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg.
- Potent and selective GlyT1 inhibitor
- IC50: 38 nM for rGlyT1
- Antipsychotic activity
- In vivo efficacy in rat novel object recognition (NOR) assay
- Appearance: Solid, White to off-white
- Formula: C22H21N5O2
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Powder at -20°C for 3 years or 4°C for 2 years; In solvent at -80°C for 6 months or -20°C for 1 month
- Solubility (In Vitro): DMSO : 25 mg/mL (64.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
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eMolecules 915412-67-8 | Medchem Express | LP-261 | 5mg | 600899960 | HY-14389 | 421.47 | C22H19N3O4S
Medchem Express | LP-261 | 5mg | 600899960 | HY-14389 | 915412-67-8 | 421.470 | C22H19N3O4S
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eMolecules 1163719-56-9 | Medchem Express | CCT196969 | 5mg | 446261937 | HY-12846 | MFCD28384201 | 513.533 | C27H24FN7O3
Medchem Express | VU591 | 5mg | 455325952 | HY-108585A | 1222810-74-3 | 368.309 | C16H12N6O5
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eMolecules GNE-495 | 1449277-10-4 | MFCD30489735 | 1mg
Apollo Scientific | GNE-495 | 1mg | 562464620 | BISN0201 | | 1449277-10-4 | MFCD30489735 | 405.433 | C22H20FN5O2
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Medchemexpress LLC HY-B0662 10mg Medchemexpress, Imidafenacin CAS:170105-16-5 Purity:>98%
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Medchemexpress, HY-B0662 10mg Imidafenacin CAS:170105-16-5 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-11021 5mg Medchemexpress, Elinogrel CAS:936500-94-6 Purity:>98%
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Medchemexpress, HY-11021 5mg Elinogrel CAS:936500-94-6 Elinogrel (PRT060128) is a potent, direct acting, competitive, and reversible platelet P2Y12 antagonist (IC50=20 nM). It is orally and intravenously available and has potent antiplatelet effects. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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eMolecules 84087-01-4 | Quinclorac | MFCD00072495 | 25g
Combi-Blocks | Quinclorac | 25g | 342861785 | OR-2463 | 98.000 | 84087-01-4 | MFCD00072495 | 242.060 | C10H5Cl2NO2
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eMolecules 866862-24-0 | 3-(3-Bromo-4-fluorophenyl)propanoic acid | MFCD12190913 | 1g
Ambeed | 3-(3-Bromo-4-fluorophenyl)propanoic acid | 1g | 525018098 | A120134 | 866862-24-0 | MFCD12190913 | 247.063 | C9H8BrFO2
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Medchemexpress LLC HY-112897 10mg Medchemexpress, IITZ-01 CAS:1807988-47-1 Purity:>98%
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Medchemexpress, HY-112897 10mg IITZ-01 CAS:1807988-47-1 IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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![Medchemexpress LLC 2-propenamide, N-[3-[2-[[4-[2-(dimethylamino)ethoxy]-2-methoxyphenyl]amino]...], trifluoroacetate | 2753348-63-7 | 99.4% | 628.60 | C30H31F3N6O6 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000297929.png-250.jpg)
Medchemexpress LLC 2-propenamide, N-[3-[2-[[4-[2-(dimethylamino)ethoxy]-2-methoxyphenyl]amino]...], trifluoroacetate | 2753348-63-7 | 99.4% | 628.60 | C30H31F3N6O6 | 10 MG
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EGFR-IN-1 TFA is an orally active, irreversible small-molecule inhibitor selective for L858R/T790M mutant forms of the epidermal growth factor receptor (EGFR). It potently inhibits gefitinib-resistant EGFR mutants and demonstrates antiproliferative activity in mutant EGFR cell lines, making it suitable for cellular assays and preclinical research.
- High mutant selectivity for L858R/T790M.
- Irreversible mode of inhibition.
- Potent antiproliferative activity in cell models.
- Supplied as a trifluoroacetate salt for stability.
- Intended for in vitro and preclinical research use.
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![Medchemexpress LLC 3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-py | 2830555-70-7 | >97.0% | 561.68 g·mol⁻¹ | C32H35N9O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000262915.png-250.jpg)
Medchemexpress LLC 3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-py | 2830555-70-7 | >97.0% | 561.68 g·mol⁻¹ | C32H35N9O | 5 MG
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A selective type I1/2 dual Mer and Axl receptor tyrosine kinase inhibitor for preclinical biochemical, cellular, and in vivo research. Molecular formula C32H35N9O with a molecular weight of 561.68 g·mol⁻¹. Supplied as small-mass solids and DMSO solutions with documented solubility and in vivo vehicle options.
- Highly selective type I1/2 dual Mer/Axl kinase inhibitor.
- Demonstrated in vivo efficacy in preclinical models.
- Supplied as solid and pre-made DMSO solution formats.
- Soluble at ≥ 5 mg/mL in recommended vehicles.
- High purity (≥97% by HPLC).
- Suitable for biochemical, cellular, and pharmacology studies.
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Selleck Chemical LLC Avapritinib
Avapritinib is a small molecule kinase inhibitor that potently inhibits PDGFR D842V mutant activity in vitro (IC50 0 5 nM) and PDGFR D842V autophosphorylation in the cellular setting (IC50 30 nM) also a potent inhibitor of the analogous Kit (c-Kit) mutation D816V in Kit (c-Kit) Exon 17 (IC50 0 5 nM)
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Medchemexpress LLC Jnj-54717793 | 1628843-99-1 | 98.1% | 458.41 | C22H18F4N6O | 5 MG
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JNJ-54717793 (CAS 1628843-99-1) is a brain-penetrant, orally active, selective, high-affinity orexin-1 receptor (OX1R) antagonist used in neuroscience research. Supplied as an off-white to pink solid, the compound has formula C22H18F4N6O, molecular weight 458.41, and reported purity around 98%.
- Selective orexin-1 receptor antagonist with high affinity.
- Marked selectivity versus orexin-2 receptor (lower affinity).
- Brain penetrant and orally active for in vivo studies.
- Provided as a powder with recommended cold storage for stability.
- Supplied in small research quantities suitable for preclinical experiments (5 mg).
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