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Filtered Search Results
Medchemexpress LLC N-[4-[2-(5-chloro-2-methoxy-4-pyrimidinyl)ethyl]-2-thiazolyl]-2-(trifluoromethyl)-4-pyridinesulfonam | 1788872-06-9 | >98.0% | 430.95 g/mol | C17H20ClFN4O2S2 | 50 MG
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Nav1.7-IN-3 is a selective, orally bioavailable small-molecule inhibitor of the voltage-gated sodium channel Nav1.7 (IC50 ≈ 8 nM) developed for neuroscience research into pain mechanisms. It shows limited central nervous system penetration and is supplied as a research reagent for in vivo and in vitro studies.
- Selective Nav1.7 inhibition with IC50 ≈ 8 nM.
- Orally bioavailable, suitable for oral dosing studies.
- Limited central nervous system penetration.
- Provided as a solid for formulation and dosing flexibility.
- Characterized by CAS 1788872-06-9 and molecular weight 430.95 g/mol.
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eMolecules 1956364-50-3 | (3AR,6AS)-REL-5,5-DIFLUOROOCTAHYDROCYCLOPENTA[C]PYRROLE HCL | AstaTech | MFCD29037432 | 183.630 | C7H12ClF2N | 95.000 | Cl.FC1(F)C[C@@H]2CNC[C@@H]2C1 | 0.1g | 599360416
(3AR,6AS)-REL-5,5-DIFLUOROOCTAHYDROCYCLOPENTA[C]PYRROLE HCL | AstaTech | 1956364-50-3 | MFCD29037432 | 183.630 | C7H12ClF2N | 95.000 | Cl.FC1(F)C[C@@H]2CNC[C@@H]2C1 | 0.1g | 599360416
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Accela Chembio Inc 4-fluorophenylboronic Acid | 100g | 1765-93-1 | MFCD00039136 | 97+% | Shelf Life: 1440 Days | Light Sensitive/nitrogen Or Argon/+4
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4-fluorophenylboronic Acid | 100g | 1765-93-1 | MFCD00039136 | 97+% | Shelf Life: 1440 Days | Light Sensitive/nitrogen Or Argon/+4
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Medchemexpress LLC Ono-2952 | 895169-20-7 | MFCD32661907 | 99.5% | 398.9 g/mol | C22H20ClFN2O2 | 5 MG
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ONO-2952 is a potent, selective, orally active translocator protein 18 kDa (TSPO) antagonist used in pharmacology research. It displays low-nanomolar binding affinity to rat and human TSPO and has been evaluated in studies related to gastrointestinal pain and irritable bowel syndrome.
- Potent TSPO antagonist with Ki in the low nanomolar range.
- High chemical purity (≈99.5%).
- Molecular formula C22H20ClFN2O2; mol wt 398.9 g/mol.
- Available as solid and as 10 mM solution in DMSO for stock preparation.
- Supplied in small research quantities suitable for assay development.
- Characterized for identity (CAS 895169-20-7) with supporting spectral data.
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Apexbio Technology LLC AS 2034178 10MG
AS 2034178 10MG APEXBIO TECHNOLOGIES
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Medchemexpress LLC Acetamide, N-[2-[[4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-1,3,5-triazin-2-yl)amino]ethyl] | 2767424-13-3 | 98.0% | C21H23N5O2 | 10MG
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PD-L1-IN-1 is a small-molecule inhibitor of the PD-1/PD-L1 immune checkpoint intended for research use. It binds PD-L1, shows an IC50 of 115 nM, enhances IFN-γ release and peripheral blood mononuclear cell-mediated killing of PD-L1-expressing cancer cells, and induces apoptosis while showing low cytotoxicity in healthy cells.
- Potent PD-L1 inhibition (IC50 115 nM).
- Enhances IFN-γ release and immune cell-mediated tumor cell killing.
- Induces apoptosis in PD-L1-expressing cancer cell lines.
- Low cytotoxicity in noncancerous cells.
- High solubility in DMSO for assay preparation.
- Defined storage recommendations for powder and solutions.
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Medchemexpress LLC DX600 | 478188-26-0 | 99.7% | 3074.33 | 5 MG
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DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE. It has been shown to exacerbate diabetes-induced cardiovascular dysfunction and increase cardiac and renal NOX activity.
- Selective ACE2 specific inhibitor (KD: 1.3 nM)
- Does not cross-react with ACE
- Inhibits rhACE2 activity by 47% at 1 μM
- Inhibits ACE2 activity by 42% in human MNCs at 10 μM
- Decreases NR 8383 cell growth and increases TNF-a and IL-6 content at 100 nM
- Exacerbates diabetes-induced cardiovascular dysfunction in diabetic rats
- Increases thrombus weight by 30% in a thrombosis model in rats
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Selleck Chemical LLC MM-102
MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the WDR5/MLL1 protein-protein interaction which bind to WDR5 with Ki 1 nM and IC50 2 4nM This product may precipitate when dissolved in saline solution or PBS solution It is recommended to prepare the stock solution in DMSO solution
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Apexbio Technology LLC NF 340 10MG
NF 340 10MG APEXBIO TECHNOLOGIES
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eMolecules 945966-46-1 | Medchem Express | Apararenone | 5mg | 446259448 | HY-109002 | 364.39 | C17H17FN2O4S
Medchem Express | Apararenone | 5mg | 446259448 | HY-109002 | 945966-46-1 | 364.390 | C17H17FN2O4S
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Medchemexpress LLC Oritinib | 2035089-28-0 | 99.6% | 539.67 g/mol | C31H37N7O2 | 5 MG
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Oritinib is an irreversible, third-generation EGFR tyrosine kinase inhibitor developed to overcome T790M-mediated resistance. Supplied as a high-purity solid research compound, it is used in preclinical biochemical and cellular studies to interrogate EGFR signaling and resistance mechanisms.
- Irreversible third-generation EGFR inhibitor.
- Active against T790M resistance mutations.
- High chemical purity (99.6%).
- Provided as a solid suitable for dosing and formulation.
- Applicable to biochemical and cellular assays.
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Selleck Chemical LLC 2-deoxyuridine
2 -deoxyuridine (dU 2 -dU) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms
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Medchemexpress LLC CDK12-IN-3 | 2220184-50-7 | 99.9% | 470.52 | 50 MG
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CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay. It is for research use only and not sold to patients.
- Potent and selective CDK12 inhibitor.
- IC50 of 491 nM in enzymatic assay.
- Shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II (at 0.1 μM).
- Exhibits growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells.
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Medchemexpress LLC 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole | 872726-44-8 | MFCD12024619 | 99.8% | 289.32 g/mol | C15H12FNO2S | 5 MG
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GW 610 is a fluorinated 2-arylbenzothiazole antitumor agent used in research to study aryl hydrocarbon receptor (AhR)-mediated pathways and anticancer activity in cell lines. It induces CYP1A1 expression in MCF-7 cells and shows selective growth-inhibitory effects against lung, colon, and breast cancer cell lines.
- Potent aryl hydrocarbon receptor ligand, useful for AhR pathway studies.
- Induces CYP1A1 expression in MCF-7 cells.
- Demonstrates selective anticancer activity against lung, colon, and breast cancer cell lines.
- High chemical purity reported (99.8%), suitable for research use.
- Molecular weight 289.32 g/mol; chemical formula C15H12FNO2S.
- Store at 4°C protected from light; in solvent store at -80°C (up to 6 months) or -20°C (up to 1 month).
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Medchemexpress LLC Cep-40783 | 1437321-24-8 | 99.6% | 588.56 g/mol | C31H26F2N4O6 | 500 MG
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CEP-40783 is a potent, selective, orally available small-molecule inhibitor of the receptor tyrosine kinases AXL and c-Met. It exhibits low-nanomolar biochemical and cellular activity and is intended for preclinical research on RTK signaling and oncology models.
- Potent dual inhibition of AXL and c-Met at low nanomolar concentrations.
- Demonstrated cellular activity in transfected and tumor cell lines.
- High purity suitable for biochemical and cellular assays.
- Powder stable at -20°C for long-term storage; solutions stable at -80°C.
- Available in a 500 mg package size for research use.
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