Phenoxy compounds
Medchemexpress LLC Phenoxybenzamine hydrochloride | 63-92-3 | 99.5% | 50 MG
Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist. It is commonly used for the research of hypertension, specifically that caused by pheochromocytoma. It also demonstrates antitumor activity.
- Nonselective, irreversible, orally active α-adrenoceptor antagonist
- Used for research on hypertension caused by pheochromocytoma
- Demonstrates antitumor activity
Medchemexpress LLC Phenoxybenzamine hydrochloride | 63-92-3 | 99.5% | 25 MG
Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist commonly used for hypertension research, particularly for pheochromocytoma. It also demonstrates antitumor activity.
- Inhibits U251 and U87MG cell proliferation.
- Inhibits migration and invasion of U251 and U87MG cells.
- Activates LINGO-1 and inhibits the TrkB-Akt pathway.
- Prevents hippocampal cell death after oxygen glucose deprivation.
- Shows anti-tumorigenic effect in nude mice with U87MG tumors.
- Neuroprotective in a rat model of severe traumatic brain injury.
Medchemexpress LLC Phenoxybenzamine hydrochloride | 63-92-3 | 99.5% | 500 MG
Phenoxybenzamine hydrochloride is a nonselective, irreversible, and orally active alpha-adrenoceptor antagonist. It is utilized in research concerning hypertension, particularly when caused by pheochromocytoma, and has demonstrated antitumor activity. This compound also exhibits significant biological activity in various in vitro and in vivo studies.
- Nonselective and irreversible alpha-adrenoceptor antagonist
- Orally active compound
- Used in hypertension research for pheochromocytoma
- Exhibits antitumor activity
- Inhibits cell proliferation, migration, and invasion
- Activates LINGO-1 and inhibits the TrkB-Akt pathway
- Prevents hippocampal cell death after oxygen glucose deprivation
- Shows anti-tumorigenic effects in tumor models
- Provides neuroprotective benefits in traumatic brain injury models
Medchemexpress LLC Phenoxybenzamine hydrochloride | 63-92-3 | 99.5% | 1 G
Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist. It is primarily used in research for hypertension, particularly that caused by pheochromocytoma, and has also demonstrated antitumor activity.
- Inhibits proliferation of U251 and U87MG cells.
- Inhibits migration and invasion of U251 and U87MG cells.
- Activates LINGO-1 and inhibits the TrkB-Akt pathway.
- Prevents hippocampal cell death after oxygen glucose deprivation.
- Demonstrates anti-tumorigenic effect in nude mice with U87MG tumors.
- Exhibits neuroprotective properties in a rat model of severe traumatic brain injury.
Medchemexpress LLC Phenoxybenzamine hydrochloride | 63-92-3 | MFCD00055152 | 99.5% | 1 ML
Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist. It is commonly utilized in research related to hypertension, particularly that caused by pheochromocytoma, and also demonstrates antitumor activity. This product is supplied as a 10 mM solution in DMSO, ensuring high purity for various laboratory applications.
- Nonselective and irreversible α-adrenoceptor antagonist
- Orally active compound
- Used in hypertension research, specifically for pheochromocytoma
- Exhibits antitumor activity
- Provided as a 10 mM solution in DMSO
Medchemexpress LLC Phenoxybenzamine hydrochloride | 63-92-3 | MFCD00055152 | 99.5% | 100 MG
Phenoxybenzamine hydrochloride (Standard) serves as the analytical standard for Phenoxybenzamine hydrochloride, intended for research and analytical applications. It is an irreversible, nonselective, and orally active α-adrenoceptor antagonist, frequently employed in hypertension research, particularly for cases caused by pheochromocytoma. This compound also exhibits antitumor activity.
- Analytical standard for phenoxybenzamine hydrochloride
- Intended for research and analytical applications
- Nonselective α-adrenoceptor antagonist
- Irreversible α-adrenoceptor antagonist
- Orally active α-adrenoceptor antagonist
- Used in research for hypertension caused by pheochromocytoma
- Shows antitumor activity
- Commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS
Apexbio Technology LLC Phenoxybenzamine HCl 63-92-3 10mM (in 1mL DMSO)
Phenoxybenzamine HCl (CAS number 63-92-3) is an irreversible nonselective antagonist of alpha-adrenergic receptors It covalently binds to these receptors producing sustained blockage and therefore preventing receptor-mediated vasoconstriction Due to this prolonged alpha-receptor antagonism phenoxybenzamine hydrochloride is frequently utilized in biomedical research to study sympathetic nervous system functions receptor pharmacology and cardiovascular-related pathophysiology
Medchemexpress LLC Phenoxybenzamine hydrochloride | 63-92-3 | MFCD00055152 | 99.5% | 340.29 | C18H23Cl2NO | 10 MG
Phenoxybenzamine hydrochloride is an analytical standard of the α-adrenoceptor antagonist phenoxybenzamine supplied as a characterized hydrochloride salt for laboratory research and analytical use. The material is intended for method development, calibration, and quality control where a high-purity reference standard is required.
- High purity (≈99.5%) for accurate analytical reference.
- Supplied as the hydrochloride salt for improved stability.
- Suitable for method development, calibration, and quality control.
- Provided with certificate of analysis and safety data sheet.
- Available in small research pack sizes, including 10 mg.
Medchemexpress LLC PXS-5153A (monohydrochloride) | 2125956-82-1 | 99.6% | 438.95 | 50 MG
PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorate fibrosis.
- Exhibits an IC50 of <40 nM for LOXL2 across all mammalian species tested.
- Also inhibits human LOXL3 with an IC50 value of 63 nM.
- Is >40-fold selective for LOXL2 over both LOX and LOXL1 and >700-fold selective over other related amine oxidases.
- Is a fast acting inhibitor, with enzymatic activity almost entirely blocked within 15 minutes.
- Reduces crosslinks and ameliorates fibrosis.
Medchemexpress LLC PXS-5153A monohydrochloride | 2125956-82-1 | 99.59% | 438.95 | 100 MG
PXS-5153A monohydrochloride is a potent, selective, orally active, and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor. It has an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. This compound can reduce crosslinks and ameliorate fibrosis.
- Potent, selective, orally active, and fast-acting LOXL2/LOXL3 inhibitor.
- IC50 of <40 nM for LOXL2 across all mammalian species.
- IC50 of 63 nM for human LOXL3.
- >40-fold selective for LOXL2 over LOX and LOXL1.
- >700-fold selective over other related amine oxidases.
- Fast-acting, with enzymatic activity almost entirely blocked within 15 minutes.
- Reduces crosslinks and ameliorates fibrosis.
Medchemexpress LLC HY-114286A 5mg Medchemexpress, PXS-5153A (monohydrochloride) CAS: Purity:>98%
Medchemexpress, HY-114286A 5mg PXS-5153A (monoHCl) CAS: PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorates fibrosis. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.