Phenylhydrazines
Medchemexpress LLC Triprolidine (hydrochloride) | 550-70-9 | MFCD00039044 | 99.8% | 314.85 g/mol | C19H23ClN2 | 10 MG
Triprolidine hydrochloride is a first-generation antihistamine and an orally active histamine H1 receptor antagonist supplied for research use. It is provided as a white to off-white solid with high reported purity and is available in small-milligram pack sizes for laboratory studies.
- First-generation H1 receptor antagonist for research applications.
- High purity suitable for analytical and in vitro assays.
- Available in small mg quantities for screening and dose-response studies.
- White to off-white solid, easy to weigh and dissolve in common solvents.
- Store sealed away from moisture; recommended storage: 4°C for solid, in solvent: -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical use.
Accela Chembio Inc 4-(trifluoromethoxy)phenylhydrazine Hydrochloride | 25g | 133115-72-7 | MFCD00053033 | 97+% | Shelf Life: 1260 Days | N2
4-(trifluoromethoxy)phenylhydrazine Hydrochloride | 25g | 133115-72-7 | MFCD00053033 | 97+% | Shelf Life: 1260 Days | N2
eMolecules 60481-49-4 | (3-Ethyl-phenyl)-hydrazine hydrochloride | J & W PharmLab LLC | MFCD06738782 | 172.660 | C8H13ClN2 | 96.000 | Cl.CCc1cccc(NN)c1 | 1g | 456105698
(3-Ethyl-phenyl)-hydrazine hydrochloride | J & W PharmLab LLC | 60481-49-4 | MFCD06738782 | 172.660 | C8H13ClN2 | 96.000 | Cl.CCc1cccc(NN)c1 | 1g | 456105698
Medchemexpress LLC Palonosetron hydrochloride | 135729-62-3 | 99.94% | C19H25ClN2O | 1 ML
Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. It also exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells, and possesses antidepressant activity.
- 5-HT3 antagonist
- Prevents acute, delayed, and overall chemotherapy-induced nausea and vomiting
- Exhibits moderate anti-flavivirus activity
- Possesses potent anti-Zika virus activity in mammalian cells
- Possesses antidepressant activity
- Inhibits enhancement effect of 5-HT on substance P (SP)-induced calcium release in NG108-15 cells
- Reduced immobility in Swiss albino mice
- Dose-dependently inhibited SP-mediated neuronal responses in the Cisplatin-induced rat emesis model
eMolecules 52033-74-6 | Phenylhydrazine sulfate | MFCD00070608 | 5g
Combi-Blocks | Phenylhydrazine sulfate | 5g | 517033885 | QA-9825 | 95.000 | 52033-74-6 | MFCD00070608 | 314.360 | C12H18N4O4S
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Medchemexpress LLC Besifloxacin (Hydrochloride) | 405165-61-9 | 98.5% | 430.30 | 25 MG
Besifloxacin Hydrochloride is a fourth-generation fluoroquinolone antibiotic that functions as a DNA gyrase and topoisomerase IV inhibitor. It exhibits broad-spectrum antibacterial activity against Gram-negative and Gram-positive aerobic and anaerobic strains and helps reduce the incidence of drug resistance. It also possesses anti-inflammatory properties and can be utilized in bacterial conjunctivitis research.
- Functions as a DNA gyrase and topoisomerase IV inhibitor.
- Exhibits broad-spectrum antibacterial activity against Gram-negative and Gram-positive aerobic and anaerobic strains.
- Reduces the incidence of drug resistance.
- Possesses anti-inflammatory activity.
- Can be used in bacterial conjunctivitis research.
Medchemexpress LLC Tetracycline hydrochloride | 64-75-5 | 98.7% | 100 MG
Tetracycline hydrochloride | 64-75-5 | 98.7% | 100 MG
Medchemexpress LLC JH-X-119-01 hydrochloride | 2591344-30-6 | 99.1% | 488.93 | 10 MG
JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. It ameliorates LPS-induced sepsis in mice by decreasing phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro. It selectively inhibits IRAK1 phosphorylation. In vivo, it improves survival and decreases immunopathies of LPS-challenged mice, increasing survival at doses of 5 mg/kg and 10 mg/kg body weight.
- Potent and selective IRAK1 inhibitor
- Ameliorates LPS-induced sepsis in mice
- Decreases phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro
- Selectively inhibits IRAK1 phosphorylation
- Improves survival and decreases immunopathies in LPS-challenged mice
- For research use only
Apexbio Technology LLC CK-636 442632-72-6 25mg
CK-636 is a small molecule inhibitor targeting the Arp2/3 protein complex which regulates actin nucleation and polymerization Specifically CK-636 binds between Arp2 and Arp3 subunits preventing them from adopting the active conformation needed for initiating filamentous actin assembly In biochemical assays CK-636 inhibited Arp2/3-mediated actin polymerization induced by human bovine and fission yeast Arp2/3 complexes with reported IC50 values of 4 M 32 M and 24 M respectively Additionally CK-636 suppressed Arp2/3-dependent actin filament formation in live SKOV3 cells infected with Listeria bacteria exhibiting a concentration-dependent effect (IC50 approximately 22 M) This compound serves as a research tool for studying molecular mechanisms and biological functions involving Arp2/3-mediated cytoskeletal remodeling particularly in the context of cell adhesion junctional integrity and epithelial differentiation
Medchemexpress LLC Valacyclovir hydrochloride | 124832-27-5 | MFCD01861507 | 99.0% | 10 MG
Valacyclovir hydrochloride is the hydrochloride salt of valacyclovir, an orally active antiviral prodrug of acyclovir used against herpes simplex and herpes zoster. Supplied for research and analytical use, this solid reagent is intended as a reference standard or for antiviral studies and method development.
- Orally active antiviral prodrug of acyclovir
- Hydrochloride salt supplied as a solid for research use
- Analytical standard with reported purity 99.0% (HPLC)
- Molecular weight 360.80 and formula C13H21ClN6O4
- Suitable for antiviral research and reference standard applications
- Available in small pack sizes for analytical work
Chemscene ChemScene | (4-Fluorophenyl)hydrazine | 10G | CS-0183141 | 0.96 | 371-14-2| MFCD00041262 | 126.13
ChemScene | (4-Fluorophenyl)hydrazine | 10G | CS-0183141 | 0.96 | 371-14-2| MFCD00041262 | 126.13
Medchemexpress LLC Pioglitazone hydrochloride | 112529-15-4 | 100.0% | C19H21ClN2O3S | 5 G
Pioglitazone hydrochloride is a potent and selective PPARγ agonist, commonly used in research for ferroptosis, metabolic disease, and cancer. It impacts cellular processes through various pathways including cell cycle/DNA damage, metabolic enzyme/protease, vitamin D related/nuclear receptor, and apoptosis.
- Functions as a potent and selective PPARγ agonist.
- Known by synonyms U 72107A and AD 4833.
- Explored in research areas such as PPAR, ferroptosis, metabolic disease, and cancer.
- Affects pathways including cell cycle/DNA damage, metabolic enzyme/protease, vitamin D related/nuclear receptor, and apoptosis.
- Demonstrates activity with human PPARδ and PPARα.
- Cited in 42 publications.
Medchemexpress LLC JBSNF-000028 hydrochloride | C11H14ClN3 | 100 MG
JBSNF-000028 hydrochloride is an orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT), with IC50 values for human, mouse, and monkey NNMT of 33, 210, and 190 nM, respectively. It reduces endogenous MNA levels in U2OS cells (EC50 2.5 μM) and shows significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. It is suitable for studying metabolic diseases like obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Inhibits NNMT activity in U2OS cells (EC50 2.5 μM).
- Shows no cytotoxicity against HepG2 cells at 10-100 μM.
- Binds below a hairpin structural motif at the nicotinamide pocket.
- Inactive against a broad panel of metabolism-related targets.
- Improves glucose and lipid handling in mice with diet-induced obesity.
- Enhances glucose tolerance in NNMT knockout DIO mice.
Medchemexpress LLC Procainamide hydrochloride | 614-39-1 | 99.5% | C13H22ClN3O | 1 mL
Procainamide hydrochloride is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). It reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes, and can induce vacuolization in various cell types, reducing cell proliferation and migration. It also relaxes airway smooth muscle by activating potassium channels. This product is suitable for use in cancer and arrhythmia research.
- Specific and potent inhibitor of DNA methyltransferase 1
- Reactivates tumor suppressor gene expression
- Induces cellular vacuolization
- Reduces cell proliferation and migration
- Relaxes airway smooth muscle
- Causes loss of CpG methylation
- Demethylates ER, p16, and RAR genes
- Useful in cancer research
- Useful in arrhythmia research
Medchemexpress LLC Cardiogenol C hydrochloride | 1049741-55-0 | 99.8% | 296.75 g/mol | C13H17ClN4O2 | 10MG
Cardiogenol C hydrochloride is a cardiomyogenic small-molecule research compound used to induce differentiation of pluripotent stem cells into cardiomyocytes and to study cardiac development and repair. Supplied as the hydrochloride salt with high reported purity, it is provided in small laboratory pack sizes for research applications.
- Induces cardiomyogenic differentiation in embryonic and pluripotent stem cells.
- High reported purity (99.8%).
- Molecular formula C13H17ClN4O2; molecular weight 296.75 g/mol.
- Soluble in DMSO (≥59 mg/mL) and moderately soluble in water (≈2 mg/mL).
- Provided as a solid hydrochloride salt in small pack sizes suitable for laboratory use.
- Store solids at 4°C; solutions stable at -80°C for up to 6 months and -20°C for 1 month.