Phenylhydrazines
Medchemexpress LLC Cardiogenol C hydrochloride | 1049741-55-0 | 99.8% | 296.75 g/mol | C13H17ClN4O2 | 10MG
Cardiogenol C hydrochloride is a cardiomyogenic small-molecule research compound used to induce differentiation of pluripotent stem cells into cardiomyocytes and to study cardiac development and repair. Supplied as the hydrochloride salt with high reported purity, it is provided in small laboratory pack sizes for research applications.
- Induces cardiomyogenic differentiation in embryonic and pluripotent stem cells.
- High reported purity (99.8%).
- Molecular formula C13H17ClN4O2; molecular weight 296.75 g/mol.
- Soluble in DMSO (≥59 mg/mL) and moderately soluble in water (≈2 mg/mL).
- Provided as a solid hydrochloride salt in small pack sizes suitable for laboratory use.
- Store solids at 4°C; solutions stable at -80°C for up to 6 months and -20°C for 1 month.
Medchemexpress LLC Pexidartinib (hydrochloride) | 2040295-03-0 | 99.8% | 454.28 | 1 G
Pexidartinib (hydrochloride) | 2040295-03-0 | 99.8% | 454.28 | 1 G
Medchemexpress LLC Halofantrine hydrochloride | 36167-63-2 | 99.9% | C26H31Cl3F3NO | 5 MG
Halofantrine hydrochloride is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels and is a potent antimalarial agent. It inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. It can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.
- Exhibits antifungal activity in the Galleria mellonella model.
- Shows antimalarial activity against Plasmodium strains in vitro and in animal models.
- Can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.
Medchemexpress LLC Pexidartinib hydrochloride | 2040295-03-0 | 99.8% | 454.28 | 500 MG
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor. It induces cell apoptosis and exhibits anti-cancer activity, making it a valuable tool for cancer research.
- Potent, orally active, selective, and ATP-competitive inhibitor
- Targets CSF1R (M-CSFR) with an IC50 of 20 nM and c-Kit with an IC50 of 10 nM
- Exhibits 10- to 100-fold selectivity for these targets over other related kinases
- Induces cell apoptosis and shows anti-cancer activity
- Can deplete microglia cells in mice and reduces tissue macrophage levels
- For research use only
Medchemexpress LLC Itacnosertib hydrochloride | 2409543-84-4 | 99.4% | 505.01 | C26H29ClN8O | 5 MG
Itacnosertib hydrochloride is the hydrochloride salt of TP-0184, a small-molecule investigational inhibitor that potently targets ACVR1/ALK2 (reported IC50 ≈ 8 nM), shows activity against FLT3, and has markedly weaker activity versus JAK2 (reported IC50 ≈ 8,540 nM). It has demonstrated anti-leukemic activity in preclinical studies and is supplied for research use as a high-purity hydrochloride salt.
- Potent ACVR1/ALK2 inhibition (IC50 ≈ 8 nM).
- Activity against FLT3 with reported anti-leukemic effects.
- Markedly weaker JAK2 activity (IC50 ≈ 8,540 nM), indicating selectivity.
- Supplied as the hydrochloride salt for improved solubility.
- High reported purity (~99.4%) backed by certificate of analysis.
- Provided in small research pack sizes suitable for in vitro studies.