Phenylhydrazines
Medchemexpress LLC Tetracycline hydrochloride | 64-75-5 | 98.7% | 100 MG
Tetracycline hydrochloride | 64-75-5 | 98.7% | 100 MG
Medchemexpress LLC JH-X-119-01 hydrochloride | 2591344-30-6 | 99.1% | 488.93 | 10 MG
JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. It ameliorates LPS-induced sepsis in mice by decreasing phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro. It selectively inhibits IRAK1 phosphorylation. In vivo, it improves survival and decreases immunopathies of LPS-challenged mice, increasing survival at doses of 5 mg/kg and 10 mg/kg body weight.
- Potent and selective IRAK1 inhibitor
- Ameliorates LPS-induced sepsis in mice
- Decreases phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro
- Selectively inhibits IRAK1 phosphorylation
- Improves survival and decreases immunopathies in LPS-challenged mice
- For research use only
Apexbio Technology LLC CK-636 442632-72-6 25mg
CK-636 is a small molecule inhibitor targeting the Arp2/3 protein complex which regulates actin nucleation and polymerization Specifically CK-636 binds between Arp2 and Arp3 subunits preventing them from adopting the active conformation needed for initiating filamentous actin assembly In biochemical assays CK-636 inhibited Arp2/3-mediated actin polymerization induced by human bovine and fission yeast Arp2/3 complexes with reported IC50 values of 4 M 32 M and 24 M respectively Additionally CK-636 suppressed Arp2/3-dependent actin filament formation in live SKOV3 cells infected with Listeria bacteria exhibiting a concentration-dependent effect (IC50 approximately 22 M) This compound serves as a research tool for studying molecular mechanisms and biological functions involving Arp2/3-mediated cytoskeletal remodeling particularly in the context of cell adhesion junctional integrity and epithelial differentiation
Medchemexpress LLC Valacyclovir hydrochloride | 124832-27-5 | MFCD01861507 | 99.0% | 10 MG
Valacyclovir hydrochloride is the hydrochloride salt of valacyclovir, an orally active antiviral prodrug of acyclovir used against herpes simplex and herpes zoster. Supplied for research and analytical use, this solid reagent is intended as a reference standard or for antiviral studies and method development.
- Orally active antiviral prodrug of acyclovir
- Hydrochloride salt supplied as a solid for research use
- Analytical standard with reported purity 99.0% (HPLC)
- Molecular weight 360.80 and formula C13H21ClN6O4
- Suitable for antiviral research and reference standard applications
- Available in small pack sizes for analytical work
Medchemexpress LLC JBSNF-000028 hydrochloride | C11H14ClN3 | 100 MG
JBSNF-000028 hydrochloride is an orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT), with IC50 values for human, mouse, and monkey NNMT of 33, 210, and 190 nM, respectively. It reduces endogenous MNA levels in U2OS cells (EC50 2.5 μM) and shows significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. It is suitable for studying metabolic diseases like obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Inhibits NNMT activity in U2OS cells (EC50 2.5 μM).
- Shows no cytotoxicity against HepG2 cells at 10-100 μM.
- Binds below a hairpin structural motif at the nicotinamide pocket.
- Inactive against a broad panel of metabolism-related targets.
- Improves glucose and lipid handling in mice with diet-induced obesity.
- Enhances glucose tolerance in NNMT knockout DIO mice.
Medchemexpress LLC Medetomidine (hydrochloride) | 86347-15-1 | 99.8% | 236.74 | 5 MG
Medetomidine hydrochloride from MedChemExpress is provided for laboratory chemical applications and substance manufacturing. This product is a white to off-white solid.
- Suitable for laboratory chemicals and substance manufacturing
- White to off-white solid appearance
- Store at 4°C, sealed and away from moisture
- Purity of 99.8% confirmed by LCMS
- For research use only; not validated for medical applications
Medchemexpress LLC Methoxyamine hydrochloride | 593-56-6 | MFCD00012951 | 98.0% | 83.52 g/mol | CH5NO·HCl | 5g
Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor Methoxyamine hydrochloride binds to 3 hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents[1][2]
Medchemexpress LLC 3-nitrophenylhydrazine-13C6 hydrochloride | 1977535-33-3 | 98.3% | 195.56 | 13C6H8ClN3O2 | 5 MG
3-Nitrophenylhydrazine-13C6 hydrochloride is the 13C-labeled isotopologue of 3-nitrophenylhydrazine supplied as the hydrochloride salt. It serves as a tracer and internal standard for quantitative analytical workflows, and is commonly used after derivatization to enhance detection by NMR, GC-MS, and LC-MS.
Medchemexpress LLC Eflornithine hydrochloride | 68278-23-9 | 99.9% | 100 MG
Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. It is a medication used for the treatment of African trypanosomiasis and excessive facial hair growth in women. It is for research use only.
- Specific, irreversible inhibitor of ornithine decarboxylase.
- Medication for African trypanosomiasis.
- Treats excessive facial hair growth in women.
- Enhances hair growth inhibitory activity when applied to pretreated skin.
- Normalizes vascular responsiveness in coarctation hypertensive rats.
Medchemexpress LLC Leriglitazone hydrochloride | 146062-46-6 | 99.6% | 408.90 | C19H21ClN2O4S | 50 MG
Leriglitazone hydrochloride is a research-grade PPARγ agonist used to investigate neuroprotective, anti-inflammatory, and antioxidant mechanisms. Supplied as a solid for laboratory use, the compound is characterized for purity and recommended storage conditions.
- High purity: 99.6%.
- PPARγ agonist with neuroprotective and anti-inflammatory activity.
- Solid, white to light yellow, suitable for handling in laboratory assays.
- Available in milligram-scale packages for research studies.
- Stable when stored sealed and protected from moisture; in solvent, -80 °C for up to six months.
- Molecular weight 408.90; formula C19H21ClN2O4S.
eMolecules 658-27-5 | 3-Fluorophenylhydrazine | Oakwood Chemical | MFCD00041261 | 126.134 | C6H7FN2 | 0.000 | NNc1cccc(F)c1 | 1g | 537691688
3-Fluorophenylhydrazine | Oakwood Chemical | 658-27-5 | MFCD00041261 | 126.134 | C6H7FN2 | 0.000 | NNc1cccc(F)c1 | 1g | 537691688
Medchemexpress LLC (+)-PD 128907 hydrochloride | 300576-59-4 | 99.5% | 285.77 | 25 MG
(+)-PD 128907 hydrochloride is a selective dopamine D2/D3 receptor agonist. It functions as a biochemical reagent and can be utilized as a biological material or organic compound for life science research. It exhibits high selectivity for dopamine D3 receptors over D2 receptors.
- Potent and selective dopamine D3 receptor agonist.
- Acts on D2 and D3 dopamine receptors.
- Inhibits dialysate DA levels in D3 knockout mice.
- Displaces [3H]spiperone binding from dopamine D3 receptors.
- Involved in GPCR/G protein and neuronal signaling pathways.
Medchemexpress LLC Idalopirdine hydrochloride | 467458-02-2 | 100.0% | C20H20ClF5N2O | 10MG
Idalopirdine hydrochloride is the hydrochloride salt of idalopirdine, a selective 5-HT6 receptor antagonist supplied as a high-purity research reagent for pharmacology and neuroscience studies. It is used in preclinical investigations of cognition and neurodegenerative disease mechanisms and is available as a solid and as a DMSO solution for assay use.
- Selective 5-HT6 receptor antagonist suitable for cognition research.
- High reported purity (99.96%).
- Available in small milligram quantities and as a 10 mM solution in DMSO.
- Molecular formula C20H20ClF5N2O and molecular weight 434.83 g/mol.
- For research use only; not for human consumption.
Medchemexpress LLC Omadacycline (hydrochloride) | 1196800-39-1 | 99.5% | 593.11 | 1 G
Omadacycline hydrochloride (PTK 0796) is a first-in-class orally active aminomethylcycline antibacterial, belonging to the tetracycline class of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This compound exhibits broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. It is used in the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.
- Exhibits broad-spectrum antibacterial activity.
- Effective against aerobic and anaerobic gram-positive and gram-negative bacteria.
- Shows activity against atypical bacteria.
- Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
- Active against resistant strains including MRSA, VRE, beta-hemolytic streptococci, PRSP, and H. influenzae.
eMolecules 6971-45-5 | (2-Methoxyphenyl)hydrazine hydrochloride | ChemScene | MFCD00035456 | 174.630 | C7H11ClN2O | 97.000 | Cl.COc1ccccc1NN | 1g | 791179964
(2-Methoxyphenyl)hydrazine hydrochloride | ChemScene | 6971-45-5 | MFCD00035456 | 174.630 | C7H11ClN2O | 97.000 | Cl.COc1ccccc1NN | 1g | 791179964