Phthalic acid and derivatives
Apexbio Technology LLC Cyclic Pifithrin-α hydrobromide 511296-88-1 5mg
Cyclic Pifithrin- hydrobromide (CAS 511296-88-1) is a synthetic small molecule that functions as an inhibitor of the tumor suppressor protein p53 By blocking p53-dependent transcriptional activation of response genes it interferes with p53-mediated cellular processes such as apoptosis and cell cycle arrest In vitro Cyclic Pifithrin- hydrobromide inhibits p53-dependent apoptosis and DNA damage-induced growth arrest in various cell models without notable effects on p53-deficient cells In vivo it protects mice from the toxic side effects of genotoxic cancer therapies likely through suppression of p53-dependent pathways This compound is utilized in research investigating p53 biology cellular stress responses and modulation of chemotherapeutic toxicity
Medchemexpress LLC 1,4-Benzenedicarboxylic acid | 100-21-0 | 99.9% | 166.13 | 10 G
Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. It can also be utilized to build skin tumor models.
- Can be used in animal modeling to create skin tumor models.
- It is metabolized in the body to form calcium terephthalate or calcium hydrogen terephthalate, which can lead to bladder stone formation.
- The lithogenic effect is more pronounced in weanling mice at higher doses.
- Promotes excessive cell proliferation and induces skin tumor formation by disrupting the p16-cyclin D1/Cdk4-Rb cell cycle regulatory pathway.
- Specific modeling methods for skin tumor induction involve topical application in C57BL/6 mice.
Apexbio Technology LLC Disodium (R)-2-Hydroxyglutarate 103404-90-6 100mg
Disodium (R)-2-Hydroxyglutarate (CAS 103404-90-6) is an enantiomer of 2-hydroxyglutarate that functions as an inhibitor of ATP synthase a rotary enzyme complex critical for ATP production via oxidative phosphorylation Studies have shown that (R)-2-hydroxyglutarate accumulates in human cancers harboring IDH1 or IDH2 mutations where it suppresses ATP synthase activity leading to tumor cell growth arrest and cell death particularly under glucose-limited conditions In IDH-mutant glioma cells elevated (R)-2-hydroxyglutarate levels reduce oxygen consumption linked to ATP synthase This molecule is used to investigate metabolic vulnerabilities in malignancies with altered 2-hydroxyglutarate metabolism and the role of ATP synthase in cancer cell survival
Aobchem 2 5-Dimethylterephthalic acid | ≥95% | CAS 6051-66-7 | C10H10O4 | 1g
2 5-Dimethylterephthalic acid | ≥95% | CAS 6051-66-7 | C10H10O4 | 1g
Apexbio Technology LLC Disodium (R)-2-Hydroxyglutarate 103404-90-6 10mM (in 1mL H2O)
Disodium (R)-2-Hydroxyglutarate (CAS 103404-90-6) is an enantiomer of 2-hydroxyglutarate that functions as an inhibitor of ATP synthase a rotary enzyme complex critical for ATP production via oxidative phosphorylation Studies have shown that (R)-2-hydroxyglutarate accumulates in human cancers harboring IDH1 or IDH2 mutations where it suppresses ATP synthase activity leading to tumor cell growth arrest and cell death particularly under glucose-limited conditions In IDH-mutant glioma cells elevated (R)-2-hydroxyglutarate levels reduce oxygen consumption linked to ATP synthase This molecule is used to investigate metabolic vulnerabilities in malignancies with altered 2-hydroxyglutarate metabolism and the role of ATP synthase in cancer cell survival
Cayman Chemical 6-Carboxyfluorescein, Purity: ≥98%, CAS: 3301-79-9, 1 g
A single isomer derivative of 5(6)-carboxyfluorescein that can be used to fluorescently label biomolecules; excitation/emission maxima of 492 and 518 nm, respectively
Cayman Chemical 5-Carboxyfluorescein, Purity: ≥98%, CAS: 76823-03-5, 100 mg
A single isomer derivative of 5(6)-carboxyfluorescein that can be used to fluorescently label biomolecules; excitation/emission maxima of 492 and 518 nm, respectively
Medchemexpress LLC Terephthalic acid-13C2 | 121191-53-5 | 99.6% | 168.12 | 100 MG
Terephthalic acid-13C2 is the 13C-labeled version of Terephthalic acid, an isomer and precursor of polyester PET. It can also be used to create skin tumor models.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules for quantitation during drug development
- Deuteration can potentially affect the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Adenosine 3',5'-cyclic monophosphate | 60-92-4 | MFCD00005845 | 99.9% | 329.21 g/mol | C10H12N5O6P | 10 MG
Cyclic adenosine monophosphate (adenosine 3',5'-cyclic monophosphate; cAMP) is provided as an analytical standard for use as a calibration or reference material in quantitative biochemical and analytical assays. The material is supplied in a 10 mg vial and is intended for method development and accurate quantification of cAMP.
- Analytical standard for quantitative assays.
- High purity: 99.9% (typical).
- Suitable for HPLC, LC-MS, and ELISA calibration.
- Molecular weight 329.21 g/mol; CAS 60-92-4.
TARGETMOL CHEMICALS INC BAY 61-3606 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BAY 61-3606 (Syk inhibitor IV) is a potent ATP-competitive reversible and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) exhibiting no inhibitory effect against Btk Fyn Itk Lyn and Src. purity: 98%
Medchemexpress LLC Cyclic AMP (sodium) | 37839-81-9 | 100.0% | 10 MM, 1 ML
Cyclic AMP (Cyclic adenosine monophosphate) sodium, an adenosine triphosphate derivative, is an intracellular signaling molecule that directs cellular responses to extracellular signals. It serves as an important second messenger in many biological processes.
- Intracellular signaling molecule
- Directs cellular responses to extracellular signals
- Important second messenger in many biological processes
- Modulates mediator generation
- Suppresses the expression of pro-inflammatory cytokines (TNF-α and IL-12)
- Enhances the production of the anti-inflammatory cytokine IL-10
AdipoGen Pifithrin-alpha cyclic HBr
Chemical. CAS 511296-88-160477-34-1 free base. Formula C16H16N2S . HBr. MW 268.4 . 80.9. Stable analog of pifithrin-alpha. p53 inhibitor.
Medchemexpress LLC Cyclic GMP sodium | 40732-48-7 | 99.9% | 367.19 | 10 MG
Cyclic GMP sodium | 40732-48-7 | 99.9% | 367.19 | 10 MG
Medchemexpress LLC Cyclic N-acetyl-D-mannosamine | 7772-94-3 | MFCD00046758 | >98.0% | 221.21 g/mol | C8H15NO6 | 1 ML
Cyclic N-acetyl-D-mannosamine is an endogenous monosaccharide metabolite supplied for research use in both solid and prepared-solution formats. Vendor documentation and batch analysis describe high purity, detailed solubility data for aqueous and DMSO solutions, and recommended storage conditions for powder and solvent stocks.
- Endogenous monosaccharide metabolite used in biochemical research.
- Purity reported ≥98.0% by NMR for the referenced batch (vendor listings also show a 95.0% variant).
- Available as a 10 mM, 1 mL solution in DMSO and as solids in multiple sizes (100 mg-5 g; larger sizes by quote).
- Highly soluble in water and DMSO (vendor-reported water solubility 100 mg/mL with ultrasonic and warming).
- Provides vendor guidance for preparing stock solutions and in vivo formulations.
- Storage recommendations: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).