Aminophenols
Medchemexpress LLC WR99210 hydrochlorid 5mg | 30711-93-4 | 5 MG
WR99210 hydrochloride is a potent dihydrofolate reductase (DHFR) inhibitor used in research on Plasmodium spp. and Toxoplasma gondii, and commonly used for selection of Plasmodium transfectants. The compound is supplied as the hydrochloride salt and is intended for laboratory research use only.
- Potent DHFR inhibitor (IC50 <0.075 nM).
- Used for antimalarial research and parasite selection.
- Supplied as a hydrochloride salt for improved solubility.
- Suitable for storage at -20°C in sealed containers away from moisture.
- Available in small research quantities for lab use (e.g., 5 mg).
eMolecules Key Organics/BIONET Medetomidine Hydrochloride 7mg 564356416 AS-2748 99 000 86347-15-1 236 740 C13H17ClN2
Key Organics/BIONET Medetomidine Hydrochloride 7mg 564356416 AS-2748 99 000 86347-15-1 236 740 C13H17ClN2
Medchemexpress LLC SKI-178 | 1259484-97-3 | 99.3% | 50 MG
SKI-178 is a potent inhibitor of both sphingosine kinase-1 (SphK1) and sphingosine kinase-2 (SphK2). It demonstrates cytotoxicity in various cancer cell lines, including agent-sensitive and multi-agent resistant types, with IC50 concentrations ranging from 0.1 to 1.8 μM. This compound has been shown to induce apoptosis in human acute myeloid leukemia cell lines in a CDK1-dependent manner and correlates with prolonged Bcl-2 phosphorylation. In in-vivo studies, SKI-178 inhibited leukemic progression in the MLL-AF9 mouse model, leading to a decrease in white blood cell counts.
- Potent SphK1 and SphK2 inhibitor
- Exhibits cytotoxicity in various cancer cell lines
- Induces apoptosis in human acute myeloid leukemia cells
- Correlates with prolonged Bcl-2 phosphorylation
- Inhibits leukemic progression in MLL-AF9 mouse model
Medchemexpress LLC LCKLSL hydrochloride | 98.1% | 712.34 | 1 MG
LCKLSL hydrochloride is an N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. It potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2, inhibits the generation of plasmin, and has anti-angiogenic roles. In human retinal microvascular endothelial cells (RMVECs), LCKLSL inhibits plasmin generation and suppresses VEGF-induced tPA activity under hypoxic conditions. Application in in vivo models of angiogenesis demonstrates suppression of angiogenic responses.
- Competitive annexin A2 (AnxA2) inhibitor
- Inhibits binding of tissue plasminogen activator (tPA) to AnxA2
- Inhibits generation of plasmin
- Anti-angiogenic roles
- Decreases vascular length in vivo
Cayman Chemical NGaminoLArginine hydrochlori
Inhibits nNOS, iNOS, and eNOS (Ki = 0.3, 3, and 2.5 μM, respectively); can be used both in cell culture and in vivo
Medchemexpress LLC Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1) | 75136-54-8 | 99.8% | 353.88 | 10 MG
PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. This product is intended for research and analytical applications.
- Highly selective σ1 receptor (S1R) agonist with an IC50 of 44 nM.
- Exhibits good neuroprotective effects.
- Can improve motor function and motor neuron survival in mice.
- Can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
Medchemexpress LLC G-5555 hydrochloride | 2319590-15-1 | 98.3% | 529.42 | 1 ML
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
- Excellent kinase selectivity, inhibiting only eight out of 235 kinases tested (>70% inhibition).
- High selectivity for group I PAKs.
- Negligible activity against the hERG channel (IC50 > 10 μM).
- Exhibits significantly greater growth inhibitory activity in PAK-amplified breast cancer cell lines.
- Low blood clearance and acceptable half-life in vivo.
- Good oral exposure (AUC=30 μM•h) and high oral bioavailability (F=80%) in vivo.
- Inhibits phosphorylation of MEK1 S298 and shows 60% tumor growth inhibition in xenograft models.
Medchemexpress LLC AT7519 Hydrochloride | 902135-91-5 | 99.2% | C16H18Cl3N5O2 | 1 ML
AT7519 Hydrochloride is a potent inhibitor of cyclin-dependent kinases (CDKs), with low nanomolar IC50s for CDK1, CDK2, CDK4-CDK6, and CDK9. It induces cytotoxicity and apoptosis in multiple myeloma (MM) cells, linked to GSK-3β activation and inhibition of RNA polymerase II. The compound inhibits tumor growth in MM xenograft mouse models and has been involved in clinical trials for various cancers.
- Potent inhibitor of CDKs (CDK1, CDK2, CDK4-CDK6, CDK9)
- Induces cytotoxicity and apoptosis in MM cells
- Overcomes cytokine and BMSC protective effects
- Inhibits RNA polymerase II CTD phosphorylation and RNA synthesis
- Inhibits cell cycle progression and reduces antiapoptotic protein levels
- Inhibits tumor growth in MM xenograft mouse models
Medchemexpress LLC Bepridil hydrochloride | 68099-86-5 | MFCD00065498 | 100.0% | 403.00 g/mol | C24H35ClN2O | 5 MG
Bepridil hydrochloride is the hydrochloride salt of bepridil, a non-selective calcium channel blocker with antianginal activity supplied as a research reagent for in vitro and analytical applications.
- High purity solid (99.98%) suitable for analytical and in vitro research.
- Non-selective calcium channel blocker, useful for cardiovascular and ion-channel studies.
- Available in small analytical pack sizes for assay development and screening.
- Stable when stored sealed and away from moisture; recommended -20°C for long-term storage.
- Also available as a ready-to-use solution (10 mM in DMSO) for assay workflows.
Medchemexpress LLC IKK 16 hydrochloride | 1186195-62-9 | 99.95% | 520.09 | 200 MG
IKK 16 hydrochloride | 1186195-62-9 | 99.95% | 520.09 | 200 MG
Medchemexpress LLC UNC2025 hydrochloride | 2070015-17-5 | 100.0% | 513.12 | C28H41ClN6O | 10MM 1ML
UNC2025 hydrochloride is the hydrochloride salt of UNC2025, a potent, ATP-competitive, orally active dual MERTK/FLT3 inhibitor used in preclinical research on acute leukemia and receptor tyrosine kinase signaling. Supplied as a 10 mM solution in DMSO (1 mL), it exhibits sub-nanomolar inhibition of MERTK and FLT3 and demonstrates favorable pharmacokinetic properties for in vitro and in vivo studies.
- Potent MERTK and FLT3 inhibition at sub-nanomolar concentrations.
- Supplied as a ready-to-use 10 mM solution in DMSO for convenient dosing.
- High purity for reproducible experimental results.
- Light yellow to yellow solid appearance when provided as a dry compound.
- Store sealed and protect from moisture; in solution store at -80°C for long-term stability.
Medchemexpress LLC RS100329 hydrochloride | 1215654-26-4 | 99.6% | 462.89 g/mol | C20H26ClF3N4O3 | 25 MG
RS100329 hydrochloride is the hydrochloride salt of RS100329, a potent and selective α1A-adrenoceptor antagonist used in pharmacological research, including studies of urethral reflex contractions and benign prostatic hyperplasia. It is supplied as a solid research chemical with high reported purity and defined storage recommendations.
- Potent, selective α1A-adrenoceptor antagonist (pKi 9.6 for α1A).
- High purity (≈99.6% by HPLC), suitable for biochemical assays.
- Well-characterized small molecule: molecular weight 462.89 g/mol, formula C20H26ClF3N4O3.
- Provided as a solid hydrochloride salt for accurate dosing in experiments.
- Recommended storage: 4°C protected from light; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC R 59-022 (hydrochloride) | 93076-98-3 | MFCD34676749 | 98.9% | 496.04 g/mol | C27H27ClFN3OS | 25 MG
R 59-022 (hydrochloride) is the hydrochloride salt of a small-molecule diacylglycerol kinase inhibitor used for laboratory research. It is provided as an off-white to light yellow solid with molecular formula C27H27ClFN3OS and molecular weight 496.04 g/mol. The compound is reported with high purity and is accompanied by an SDS for safe handling and storage.
- Used as a diacylglycerol kinase inhibitor in biochemical assays.
- High purity (98.9%).
- Molecular weight 496.04 g/mol.
- Formula C27H27ClFN3OS.
- Off-white to light yellow solid appearance for easy visual inspection.
- Supplied in 25 mg research quantities suitable for screening and assay development.
Medchemexpress LLC Ski V | 24418-86-8 | MFCD07772193 | 99.0% | 254.24 g/mol | C15H10O4 | 5 MG
SKI V is a small-molecule sphingosine kinase inhibitor reported to induce apoptosis and exhibit antitumor activity in vitro. The compound is supplied as a powder for laboratory research, with molecular formula C15H10O4 and molecular weight 254.24 g/mol. Solubility and activity data support formulation in DMSO and mixed aqueous vehicles for cell-based studies.
- Inhibits sphingosine kinase and PI3K signaling.
- Demonstrates in vitro activity (IC50 ≈ 2 μM for GST-hSK).
- Reported IC50 values for additional targets provide selectivity context.
- Supplied as a powder suitable for laboratory handling and storage.
- Soluble in DMSO (~50 mg/mL) and formulatable in aqueous vehicles with co-solvents.
- Molecular weight 254.24 g/mol; chemical formula C15H10O4.
- Intended for research use only.