Aminophenols
Medchemexpress LLC UNC9994 hydrochloride | 2108826-33-9 | 99.5% | 457.84 | 50 MG
UNC9994 hydrochloride | 2108826-33-9 | 99.5% | 457.84 | 50 MG
Cayman Chemical Acetaminophen Inhibitors
An analgesic and antipyretic compound; an inhibitor of COX-2 that is selective over COX-1 (IC50s = 113.7 and 25.8 µM, respectively, in human blood ex vivo); induces ferroptotic cell death in primary mouse hepatocytes; has a metabolite that depletes glutathione reserves in the liver
Medchemexpress LLC MRL-494 hydrochloride | 2699937-04-5 | 98.6% | 1 MG
MRL-494 hydrochloride is an antibacterial agent that functions as an inhibitor of β-barrel assembly machine A (BamA), remaining impervious to efflux and the outer membrane permeability barrier. It effectively inhibits both Gram-positive and Gram-negative bacteria by lethally disrupting the cytoplasmic membrane and inhibiting Outer Membrane Proteins (OMPs) biogenesis.
- Antibacterial agent
- Inhibitor of β-barrel assembly machine A (BamA)
- Impervious to efflux and the outer membrane permeability barrier
- Inhibits gram-positive bacteria
- Inhibits gram-negative bacteria
- Lethally disrupts the cytoplasmic membrane
- Inhibits outer membrane proteins (OMPs) biogenesis
![Medchemexpress LLC Benzamide, 2-(3-aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)-hydrochloride | 2415263-08-8 | 98.7% | 429.32 | C18H18Cl2N2O4S | 5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000236424.png-250.jpg)
Medchemexpress LLC Benzamide, 2-(3-aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)-hydrochloride | 2415263-08-8 | 98.7% | 429.32 | C18H18Cl2N2O4S | 5MG
HJC0416 hydrochloride is the hydrochloride salt of a small-molecule STAT3 inhibitor that reduces STAT3 phosphorylation, inhibits cell proliferation in vitro, and has shown antitumor activity in preclinical models. It is supplied as a white to off-white solid with high analytical purity and is intended for laboratory research use only.
- Potent STAT3 inhibitor with reported in vitro IC50 0.04-1.97 μM.
- Demonstrated oral bioavailability and antitumor activity in preclinical models.
- High purity (98.7% by HPLC).
- Molecular weight 429.32 and chemical formula C18H18Cl2N2O4S.
- White to off-white solid appearance.
- Storage: -20 °C, protect from light; in solvent: -80 °C (6 months) or -20 °C (1 month).
- For laboratory research use only; not for human or clinical use.
Sigma Aldrich Fine Chemicals Biosciences SKI II >=98% (HPLC), solid | 312636-16-1 | MFCD00733553 | 10MG
SKI II >=98% (HPLC), solid | Purity: >=98% (HPLC) | Mol Wt: 302.78 | 312636-16-1 | MFCD00733553 | 10MG
Sigma Aldrich Fine Chemicals Biosciences SKI II >=98% (HPLC), solid | 312636-16-1 | MFCD00733553 | 50MG
SKI II >=98% (HPLC), solid | Purity: >=98% (HPLC) | Mol Wt: 302.78 | 312636-16-1 | MFCD00733553 | 50MG
Medchemexpress LLC Tacrine hydrochloride | 1684-40-8 | 99.9% | 1 ML
Tacrine hydrochloride is a potent brain-penetrant inhibitor of both AChE and BChE. It also acts as an NMDAR inhibitor. This compound can be utilized in research related to Alzheimer's disease.
- Potent brain-penetrant inhibitor of AChE and BChE.
- NMDAR inhibitor.
- Used for Alzheimer's disease research.
- Appearance: Solid, white to light yellow.
- Shipping: Room temperature in continental US.
- Storage: 4°C, stored under nitrogen, away from moisture.
- In solvent storage: -80°C for 6 months; -20°C for 1 month (stored under nitrogen, away from moisture).
- Solubility in H2O: 33.33 mg/mL (141.99 mM; needs ultrasonic).
Chemscene ChemScene | 2,3-Diaminophenol | 10G | CS-W005863 | 0.97 | 59649-56-8| MFCD00075199 | 124.14
ChemScene | 2,3-Diaminophenol | 10G | CS-W005863 | 0.97 | 59649-56-8| MFCD00075199 | 124.14
Sigma Aldrich Fine Chemicals Biosciences 4-Aminophenol-d7 98 atom % D | 285132-88-9 | MFCD01074232 | 1G
4-Aminophenol-d7 98 atom % D | Mol Wt: 116.17 | 285132-88-9 | MFCD01074232 | 1G
Selleck Chemical LLC OTS514 hydrochloride-2mg
OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
Medchemexpress LLC MT-7716 hydrochloride | 1215859-93-0 | 99.1% | 477.0 | C27H29ClN4O2 | 1 ML
MT-7716 hydrochloride is the hydrochloride salt of a selective non-peptide nociceptin (NOP) receptor agonist used for preclinical pharmacology research. It is supplied at high purity and is offered both as a ready-to-use DMSO solution and as solid quantities for formulation and biological testing. The compound is commonly used in studies of alcohol dependence, withdrawal, and relapse mechanisms.
Medchemexpress LLC Rgx-104 hydrochloride | 610318-03-1 | 99.9% | 632.54 | 1 MG
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene. It significantly suppresses the growth of multiple cancer types in animals, including lung cancer, melanoma, glioblastoma, ovarian, renal cell, triple-negative breast, and colon cancer, with some instances showing partial or complete tumor regression.
- Small-molecule LXR agonist.
- Modulates innate immunity via transcriptional activation of the ApoE gene.
- Significantly suppresses the growth of multiple cancer types in animals.
- Treatment causes partial or complete tumor regression in some instances.
- Available in solid form and in solution.
Medchemexpress LLC CC-115 hydrochloride | 1300118-55-1 | 98.0% | 372.81 | 100 MG
CC-115 hydrochloride is a potent dual DNA-PK and mTOR kinase inhibitor that blocks both mTORC1 and mTORC2 signaling. It inhibits PC-3 cell proliferation and demonstrates selectivity against other protein kinases and PIKKs, including good selectivity against PI3K-alpha, ATR, and ATM. It shows good in vivo PK profiles across multiple species.
- Potent and dual DNA-PK and mTOR kinase inhibitor (IC50s of 13 nM and 21 nM respectively)
- Blocks both mTORC1 and mTORC2 signaling
- Inhibits PC-3 cells proliferation with an IC50 of 138 nM
- Demonstrates selectivity against other protein kinases and PIKKs
- Shows good in vivo PK profiles across multiple species (53% in mouse, 76% in rat, and ~100% in dog oral bioavailability)
- Leads to significant tumor volume reductions and sustains inhibition in vivo
Medchemexpress LLC CWI1-2 hydrochloride | 2408590-37-2 | C22H18Cl4N6O3 | 5 MG
CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects.
- IGF2BP2 inhibitor.
- Inhibits IGF2BP2 interaction with m6A-modified target transcripts.
- Induces apoptosis and differentiation.
- Demonstrates anti-leukemic effects.
- Effective in reducing Gln uptake and impairing mitochondrial function in AML cells.
- Inhibits colony-forming ability of leukemic mouse blasts.
- Impairs self-renewal of LSC/LIC.
- Delays leukemia onset and prolongs survival in vivo.