Aminophenols
Medchemexpress LLC MRE-269-d7 | 1265295-20-2 | 99.6% | C25H22D7N3O3 | 1 MG
MRE-269-d7 is a deuterium-labeled form of MRE-269. It functions as an active metabolite of selexipag and acts as a selective IP receptor agonist. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules primarily as tracers for quantitative analysis during drug development. Deuteration can also impact the pharmacokinetic and metabolic profiles of drugs.
- This compound can be used as a tracer.
- It can be used as an internal standard for quantitative analysis.
- It is an isotope-labeled compound.
- It is suitable for use in in vivo cell experiments.
- It is useful for therapeutic drug monitoring.
Medchemexpress LLC CBL0137 hydrochloride (Curaxin-137 hydrochloride) | 1197397-89-9 | 99.7% | 372.89 | 100 MG
CBL0137 hydrochloride (Curaxin-137 hydrochloride) | 1197397-89-9 | 99.7% | 372.89 | 100 MG
Medchemexpress LLC CX-6258 hydrochloride | 1353859-00-3 | 99.0% | 498.40 | 100 MG
CX-6258 hydrochloride is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively. For research use only. We do not sell to patients.
- Potent and kinase selective pan-Pim kinases inhibitor.
- Inhibits phosphorylation of pro-survival proteins Bad and 4E-BP1 at specific Pim kinase sites.
- Exhibits robust in vivo efficacy in Pim kinases driven tumor models.
Medchemexpress LLC Acetaminophen (Paracetamol) | 103-90-2 | MFCD00002328 | 99.97% | C8H9NO2 | 500 MG
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM. It is widely used as an antipyretic and analgesic agent. It has also been identified as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor and can induce ferroptosis, leading to acute liver injury in a mice model.
- Selective cyclooxygenase-2 (COX-2) inhibitor
- Functions as an antipyretic and analgesic agent
- Potent hepatic N-acetyltransferase 2 (NAT2) inhibitor
- Induces ferroptosis
Medchemexpress LLC Acetaminophen-d3 | 60902-28-5 | >99.9% | C8H6D3NO2 | 1 MG
Acetaminophen-d3 is the deuterium labeled form of Acetaminophen, a selective cyclooxygenase-2 (COX-2) inhibitor and a widely used antipyretic and analgesic agent. It also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Acetaminophen | 103-90-2 | 99.97% | C8H9NO2 | 50 MG
Acetaminophen (Standard) is the analytical standard of Acetaminophen, intended for research and analytical applications. Also known as Paracetamol, it is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM, and a widely used antipyretic and analgesic agent. It also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
- Analytical standard grade
- Reference standard supplied assay
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Suitable for HPLC
- Suitable for GC
- Suitable for MS
eMolecules Medchem Express / BN82002 (hydrochloride) / 5mg / 694124885 / HY-112776A / / 1049740-43-3 / MFCD08276984 / 395.880 / C19H26ClN3O4
Medchem Express / BN82002 (hydrochloride) / 5mg / 694124885 / HY-112776A / / 1049740-43-3 / MFCD08276984 / 395.880 / C19H26ClN3O4
eMolecules Medchem Express / Acetaminophen-d4 / 5mg / 713707082 / HY-66005S / / 64315-36-2 / MFCD01317366 / 155.189 / C8H9NO2
Medchem Express / Acetaminophen-d4 / 5mg / 713707082 / HY-66005S / / 64315-36-2 / MFCD01317366 / 155.189 / C8H9NO2
Medchemexpress LLC Benzamide, 4-fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]-,hydrochloride | 286369-38-8 | 99.9% | 443.94 | 25 MG
S-14506 hydrochloride is a potent 5-HT1A agonist and a 5-HT2A/2C antagonist. It also exhibits dopamine antagonist properties by blocking dopamine D2 receptors. This compound inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs, with potential for research as an anxiolytic agent.
- Potent 5-HT1A agonist.
- 5-HT2A/2C antagonist.
- Displays dopamine antagonist properties by blocking dopamine D2 receptors.
- Inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs.
- Potential for the research of anxiolytic agents.
eMolecules Key Organics/BIONET - Building Blocks Medetomidine Hydrochloride 4mg 344516857 AS-2748 99 000 86347-15-1 236 740 C13H17ClN2
Key Organics/BIONET - Building Blocks Medetomidine Hydrochloride 4mg 344516857 AS-2748 99 000 86347-15-1 236 740 C13H17ClN2
Medchemexpress LLC SM-433 hydrochloride | 98.6% | 598.18 | 1 ML
SM-433 hydrochloride is a Smac mimetic that functions as an inhibitor of inhibitor of apoptosis proteins (IAPs). It demonstrates strong binding affinity for the XIAP BIR3 protein with an IC50 of less than 1 μM. It also shows potent inhibitory activity against MDA-MB-2131 human breast cancer cells and SK-OV-3 ovarian cancer cells with IC50s less than 10 μM.
- Functions as an inhibitor of apoptosis proteins (IAPs)
- Demonstrates strong binding affinity for the XIAP BIR3 protein with an IC50 of less than 1 μM
- Shows potent inhibitory activity against MDA-MB-2131 human breast cancer cells
- Shows potent inhibitory activity against SK-OV-3 ovarian cancer cells with IC50s less than 10 μM
Medchemexpress LLC ICCB-19 hydrochloride | 1803605-68-6 | 99.3% | 291.84 | 25 MG
ICCB-19 hydrochloride is an indirect inhibitor of RIPK1 kinase activity and a TRADD (TNFRSF1A associated via death domain) inhibitor. It functions by binding with the N-terminal domain of TRADD (TRADD-N), which disrupts its binding to both TRADD-C and TRAF2. This compound effectively induces autophagy and the degradation of long-lived proteins.
- Inhibits Bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM.
- Promotes autophagy via K63-linked ubiquitination of beclin 1.
- Reduces inflammatory responses in Tradd-/- mice.
- Reduces expression of TNF-induced inflammatory target gene products and cytokines.
Medchemexpress LLC IKK 16 hydrochloride | 1186195-62-9 | 99.95% | 520.09 | 10 MM * 1 ML
IKK 16 hydrochloride is an orally active IKK inhibitor, also acting as a pan-PKD and ABCB1 inhibitor. It protects against LPS-induced multiple organ dysfunction, restores renal function, alleviates fibrosis in acute kidney injury, and attenuates cardiac dysfunction by inhibiting the NF-κB pathway.
- Inhibits IκB degradation and TNFα-stimulated expression of adhesion molecules.
- Acts as an ATP-competitive inhibitor of PKD1 and inhibits PKCα and PKCδ.
- Protects against LPS-induced multiple organ dysfunction.
- Improves renal function and prevents fibrosis after acute kidney injury.
- Suppresses systemic TNFα levels and inhibits neutrophil extravasation.
- Reduces cardiac dysfunction and NF-κB pathway activation in sepsis models.
Medchemexpress LLC Biotin-4-aminophenol | 901770-40-9 | 99.45% | C16H21N3O3S | 50 MG
Biotin-4-aminophenol is a biotin-phenol analog that generates free radicals and conjugates to tyrosine residues in proteins more efficiently and selectively than the previously reported BP1. It is intended for research use only.
- Generates free radicals and conjugates to tyrosine residues in proteins.
- More efficient and selective than previously reported BP1.
- Suitable for spatiotemporal profiling of cytosolic signaling complexes in living cells.
- Can be used with 500 µM working solution for cell incubation.
- Proximity labeling reaction is triggered by H2O2.
- Reaction can be quenched using a specific buffer.
- Supports analysis of digested peptides by nano LC-MS/MS.
Medchemexpress LLC Biotin-4-aminophenol | 901770-40-9 | >99.45% | C16H21N3O3S | 1 ML
Biotin-4-aminophenol is a biotin-phenol analog that generates free radicals and conjugates to tyrosine residues in proteins. It is noted for its more efficient and selective conjugation compared to previously reported BP1. This product is intended for research use only.
- Generates free radicals
- Conjugates to tyrosine residues in proteins
- More efficient and selective conjugation than BP1
- For research use only