Aminophenols
Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | MFCD30533694 | 98.2% | 455.46 | 1 ML
AZD9056 hydrochloride is a selective, orally active inhibitor of P2X7, a receptor involved in inflammation and pain-causing diseases. It is for research use only.
- Selectively inhibits P2X7 receptors.
- Exhibits pain-relieving and anti-inflammatory effects.
- Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
- Shows inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
- Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.
- Investigated in clinical trials for conditions like rheumatoid arthritis.
Medchemexpress LLC CBL0137 hydrochloride | 1197397-89-9 | 99.7% | 372.89 | 25 MG
CBL0137 hydrochloride is a potent inhibitor of the histone chaperone FACT, known to activate p53 and inhibit NF-κB. It has demonstrated significant activity in vitro, leading to the absence of living cells at concentrations above 2.5 μM, and enhancing the efficacy of gemcitabine in pancreatic cancer cell lines. In vivo studies show it suppresses tumor growth in various xenograft models, including colon, renal cell carcinoma, and melanoma, both as monotherapy and in combination with gemcitabine. This product is intended for research use only.
- Inhibits histone chaperone FACT.
- Activates p53 and inhibits NF-κB.
- Suppresses tumor growth in xenograft models.
- Enhances gemcitabine antitumor activity.
- Suitable for in vitro and in vivo studies in cancer research.
Medchemexpress LLC Cp94253 hydrochloride | 845861-39-4 | MFCD03453293 | 98.8% | 293.79 g/mol | C15H20ClN3O | 25 MG
CP94253 hydrochloride is the hydrochloride salt of a potent, selective 5-HT1B receptor agonist used in pharmacology and neuroscience research. It is characterized by CAS 845861-39-4, molecular formula C15H20ClN3O, and a molecular weight of 293.79 g/mol. Typical purity is about 98.8%, and the compound is provided in small-scale research pack sizes under sealed, moisture-free storage.
Medchemexpress LLC HY-12467 10mg Medchemexpress, OTS964 (hydrochloride) CAS:1338545-07-5 Purity:>98%
Medchemexpress, HY-12467 10mg OTS964 (hydrochloride) CAS:1338545-07-5 OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC L-NAME hydrochloride | 51298-62-5 | 99.9% | 269.69 | 50 G
L-NAME hydrochloride is an inhibitor of nitric oxide synthase (NOS), with an IC50 of 70 μM. It acts as a precursor to the more potent NOS inhibitor L-NOARG, with its inhibitory potency increasing upon hydrolysis to L-NOARG. This compound is widely used for research into NOS activity.
- Appearance: solid, white to off-white
- Storage: -20°C, sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month
- Solubility in H2O: 100 mg/mL (370.80 mM)
- Solubility in DMSO: 100 mg/mL (370.80 mM)
- Induces hypertension models
- Induces preeclampsia models
Cayman Chemical NGaminoLArginine hydrochlori
Inhibits nNOS, iNOS, and eNOS (Ki = 0.3, 3, and 2.5 μM, respectively); can be used both in cell culture and in vivo
Cayman Chemical NGaminoLArginine hydrochlori
Inhibits nNOS, iNOS, and eNOS (Ki = 0.3, 3, and 2.5 μM, respectively); can be used both in cell culture and in vivo
Medchemexpress LLC LYN-1604 hydrochloride | 2216753-86-3 | MFCD31630830 | >=98.0% | 621.08 | C33H44Cl3N3O2 | 1 MG
A small-molecule hydrochloride salt that activates UNC-51-like kinase 1 (ULK1) with a reported EC50 of 18.94 nM. It is used in vitro to study autophagy, apoptosis, and mechanisms relevant to triple-negative breast cancer. Supplied as a solid and as a 10 mM solution in DMSO; consult the certificate of analysis for lot-specific purity and storage instructions.
- Potent ULK1 activation (EC50 = 18.94 nM).
- Supports studies of autophagy and apoptosis in cancer models.
- Available as solid and as a 10 mM solution in DMSO for assay flexibility.
- Hydrochloride salt form improves solubility for biological testing.
- Certificate of analysis available for lot-specific purity and storage instructions.
Medchemexpress LLC Acetaminophen-d3 | 60902-28-5 | >99.9% | C8H6D3NO2 | 1 MG
Acetaminophen-d3 is the deuterium labeled form of Acetaminophen, a selective cyclooxygenase-2 (COX-2) inhibitor and a widely used antipyretic and analgesic agent. It also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Bepridil hydrochloride | 68099-86-5 | MFCD00065498 | 100.0% | 403.00 g/mol | C24H35ClN2O | 100 MG
Bepridil hydrochloride is the hydrochloride salt of bepridil, a non-selective calcium channel blocker with reported antianginal activity. Supplied as a white to light yellow solid, it is used as a research reagent in cardiovascular and electrophysiology studies.
- Cas number 68099-86-5
- Chemical formula C24H35ClN2O
- Molecular weight 403.00 g/mol
- High purity suitable for research applications
- Soluble in DMSO (100 mg/mL) and in water with ultrasonic assistance
- Store sealed, away from moisture; in solution store at -80°C for long-term stability
- Available in multiple pack sizes including 100 mg
Medchemexpress LLC HAIYPRH hydrochloride | 100.0% | 929.46 | 5 MG
HAIYPRH hydrochloride is a targeting ligand that specifically binds to the transferrin receptor (TfR). It can mediate the transport of nanocarriers across the blood-brain barrier.
- Can be conjugated to liposomes for ischemic stroke targeting treatment.
- Heptapeptide that can be used to target gliomas.
- Used as a ligand to target co-delivery systems to tumor cells expressing transferrin receptors.
- Modified co-delivery systems show higher efficiency in cellular uptake and gene expression in U87 MG cells.
- Modified co-delivery systems accumulate in tumors more efficiently in vivo.
Medchemexpress LLC Melatonin-d7 | 615251-68-8 | 98.0% | C13H9D7N2O2 | 1 MG
Melatonin-d7 is a deuterium-labeled version of melatonin, a hormone produced by the pineal gland. It activates melatonin receptors and is involved in sleep, exhibiting significant antioxidative and anti-inflammatory properties. Melatonin-d7 also acts as a selective ATF-6 inhibitor, inducing apoptosis in human hepatoma cells by downregulating COX-2, and can reduce palmitic acid-induced apoptosis in mouse granulosa cells through endoplasmic reticulum stress.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes are incorporated into drug molecules for quantitation during drug development
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Trv055 hydrochloride | 25849-90-5 | 98.88% | 868.42 | 5 MG
Trv055 hydrochloride | 25849-90-5 | 98.88% | 868.42 | 5 MG