Aminophenols
Medchemexpress LLC PD153035 hydrochloride | 183322-45-4 | 99.5% | 100 MG
PD153035 hydrochloride is the hydrochloride salt of PD153035, a potent and selective epidermal growth factor receptor (EGFR) inhibitor (Ki 6 pM; IC50 25 pM) supplied as an off-white to light yellow solid for laboratory research.
- Potent EGFR inhibitor with Ki 6 pM and IC50 25 pM.
- High purity suitable for research applications.
- Off-white to light yellow solid form.
- Suitable for biochemical and cell-based assays.
- Recommended storage: sealed, away from moisture at 4°C; in solvent: -80°C (six months), -20°C (one month).
Medchemexpress LLC CBL0137 hydrochloride | 1197397-89-9 | 99.7% | 372.89 | 25 MG
CBL0137 hydrochloride is a potent inhibitor of the histone chaperone FACT, known to activate p53 and inhibit NF-κB. It has demonstrated significant activity in vitro, leading to the absence of living cells at concentrations above 2.5 μM, and enhancing the efficacy of gemcitabine in pancreatic cancer cell lines. In vivo studies show it suppresses tumor growth in various xenograft models, including colon, renal cell carcinoma, and melanoma, both as monotherapy and in combination with gemcitabine. This product is intended for research use only.
- Inhibits histone chaperone FACT.
- Activates p53 and inhibits NF-κB.
- Suppresses tumor growth in xenograft models.
- Enhances gemcitabine antitumor activity.
- Suitable for in vitro and in vivo studies in cancer research.
Medchemexpress LLC LCKLSL hydrochloride | 98.1% | 712.34 | 1 MG
LCKLSL hydrochloride is an N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. It potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2, inhibits the generation of plasmin, and has anti-angiogenic roles. In human retinal microvascular endothelial cells (RMVECs), LCKLSL inhibits plasmin generation and suppresses VEGF-induced tPA activity under hypoxic conditions. Application in in vivo models of angiogenesis demonstrates suppression of angiogenic responses.
- Competitive annexin A2 (AnxA2) inhibitor
- Inhibits binding of tissue plasminogen activator (tPA) to AnxA2
- Inhibits generation of plasmin
- Anti-angiogenic roles
- Decreases vascular length in vivo
Medchemexpress LLC CC-115 (hydrochloride) | 1300118-55-1 | 98.0% | 372.81 | 25 MG
CC-115 hydrochloride is a potent dual inhibitor of DNA-PK and mTOR kinase. It effectively blocks both mTORC1 and mTORC2 signaling pathways, with IC50 values of 13 nM and 21 nM respectively. This product is intended for research use only.
- Potent and dual DNA-PK and mTOR kinase inhibitor
- Blocks both mTORC1 and mTORC2 signaling
- Exhibits good in vivo PK profiles across multiple species
- Demonstrates significant tumor volume reductions in tested models
- Sustains inhibition for prolonged periods
- Available in various sizes, including solid and pre-made solutions
Medchemexpress LLC HY-15373 100mg , Fenretinide 4-HPR;(4-Hydroxyphenyl)retinamide CAS:65646-68-6 Purity:98%
Medchemexpress, HY-15373 100mg Fenretinide 4-HPR;(4-Hydroxyphenyl)retinamide CAS:65646-68-6 Formula:C26H33NO2 Purity:98% Fenretinide is a synthetic retinoid deriverative, binding to the retinoic acid receptors ( RAR ) at concentrations necessary to induce cell death. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Bepridil hydrochloride | 68099-86-5 | MFCD00065498 | 100.0% | 403.00 g/mol | C24H35ClN2O | 100 MG
Bepridil hydrochloride is the hydrochloride salt of bepridil, a non-selective calcium channel blocker with reported antianginal activity. Supplied as a white to light yellow solid, it is used as a research reagent in cardiovascular and electrophysiology studies.
- Cas number 68099-86-5
- Chemical formula C24H35ClN2O
- Molecular weight 403.00 g/mol
- High purity suitable for research applications
- Soluble in DMSO (100 mg/mL) and in water with ultrasonic assistance
- Store sealed, away from moisture; in solution store at -80°C for long-term stability
- Available in multiple pack sizes including 100 mg
Medchemexpress LLC Sotalol hydrochloride | 959-24-0 | 99.9% | 50 MG
Sotalol hydrochloride is an orally active, non-selective β-adrenergic receptor blocker. It functions as a potent antiarrhythmic agent suitable for research on pediatric arrhythmias. It blocks β-receptors and potassium KCNH2 channels, and is also identified as an Antiepileptic Agent.
- Orally active
- Non-selective β-adrenergic receptor blocker
- Potent antiarrhythmic agent
- Blocks β-receptors and potassium KCNH2 channels
- Antiepileptic agent
- In vivo effects up to 100 mg/kg do not impact electroconvulsive threshold
- Does not interfere with antielectroshock action of several antiepileptic drugs at 80-100 mg/kg
- Does not impair motor performance or long-term memory when used alone or in combination with antiepileptics
Medchemexpress LLC HLCL-61 hydrochloride | 1158279-20-9 | MFCD09446681 | 99.9% | 380.91 g/mol | C23H25ClN2O | 1 ML
HLCL-61 hydrochloride is a small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) supplied for research use. It is provided as concentrated DMSO stock solutions and as solid material for in vitro and in vivo studies; not for human or veterinary use.
- First-in-class PRMT5 inhibitor for research applications.
- Available as 10 mM stock solutions in DMSO and as solids in multiple sizes.
- High reported purity (approximately 99.9%).
- Soluble in DMSO (≈131 mM at 50 mg/mL) and poorly soluble in water.
- Storage: sealed at 4°C for solids; in solvent -80°C for long-term storage.
- Identifying information: CAS number 1158279-20-9; molecular weight ≈380.91 g/mol.
eMolecules 127818-58-0 | 3-METHYL-5-NITROPHENOL | MFCD09038591 | 1g
Ambeed | 13-Benzenedimethanamine | 25g | 600851593 | A566345 | 1477-55-0 | MFCD00008119 | 136.198 | C8H12N2
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![Medchemexpress LLC Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-isopropyl-7-oxo-5-phenyl hydrochloride | 2095432-28-1 | 100.0% | 314.77 g/mol | C16H15ClN4O | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213936.png-250.jpg)
Medchemexpress LLC Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-isopropyl-7-oxo-5-phenyl hydrochloride | 2095432-28-1 | 100.0% | 314.77 g/mol | C16H15ClN4O | 1 MG
CPI-455 hydrochloride is the hydrochloride salt of a potent pan-KDM5 histone demethylase inhibitor with reported low-nanomolar activity against KDM5A. It is intended for research use in epigenetics and cancer biology to elevate H3K4me3 levels and probe mechanisms of drug-tolerant persister cells. Supplied as a high-purity reagent for in vitro studies.
- Potent pan-KDM5 inhibition with low-nanomolar activity against KDM5A.
- Elevates global H3K4me3 levels in cellular assays.
- High purity suitable for research-grade experiments.
- Available in small milligram pack sizes for screening and assays.
- Hydrochloride salt form improves aqueous solubility for formulation.
eMolecules 86347-15-1 | Medetomidine Hydrochloride | Key Organics/BIONET - Building Blocks236.740 | C13H17ClN2 | 99.000 | Cl.CC(c1cnc[nH]1)c1cccc(C)c1C | 4mg | 344516857
Medetomidine Hydrochloride | Key Organics/BIONET - Building Blocks | 86347-15-1236.740 | C13H17ClN2 | 99.000 | Cl.CC(c1cnc[nH]1)c1cccc(C)c1C | 4mg | 344516857
Medchemexpress LLC Rs 67333 hydrochloride | 168986-60-5 | 99.7% | 389.36 g·mol⁻1 | C19H30Cl2N2O2 | 10 MG
RS 67333 hydrochloride is a research-grade small molecule that acts as a potent and selective partial agonist of the 5-HT4 (serotonin) receptor. It is commonly used in neuroscience research, including studies of neuroprotection and Alzheimer's disease models, to probe 5-HT4-mediated signaling.
- Potent and selective 5-HT4 receptor partial agonist (pKi ≈8.7).
- Used in neuroscience and neurodegeneration research models.
- High purity (~99.7%).
- Molecular weight 389.36 g·mol⁻1.
- CAS number 168986-60-5.
- Available in small research quantities, such as 10 MG, and stored sealed away from moisture.
Cayman Chemical N-acetyl-2-AmInophenol 50g
A derivative of acetaminophen; inhibits ADP- or arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 50 µM; decreases disease severity and prevents increases in paw volume in a rat model of collagen-induced arthritis at 1 mg/kg; has been used as a synthetic intermediate in the synthesis of compounds with antimalarial activity; a potential impurity in commercial preparations of acetaminophen