Aminophenols
Medchemexpress LLC dAURK-4 (hydrochloride) | 99.4% | 1071.93 | 100 MG
dAURK-4 hydrochloride is a potent and selective PROTAC AURKA (Aurora A) degrader. This derivative of Alisertib exhibits anticancer effects and is composed of a ligand for target protein, a linker, and a ligand for E3 ligase.
- Potent and selective degrader of AURKA (Aurora A)
- Exhibits anticancer effects
- Degrades AURKA in a dose-dependent manner (125-1000 nM; 4-24 hours)
- Inhibits protein level of AURKA (Aurora A) in MM.1S cells
Medchemexpress LLC DC-Chol hydrochloride | 166023-21-8 | >99.9% | 537.26 | 250 MG
DC-Chol hydrochloride is a cationic lipid that inhibits Aβ40 fibril formation and amyloidogenesis of oxidized hCT. It enhances the body's immune response to antigens by inducing the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. This compound is also utilized as a gene delivery vector.
- Can inhibit Aβ40 fibril formation
- Strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner
- Induces production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines
- Enhances the body's immune response to antigens
- Used as a gene delivery vector
- Can be used in research for hepatitis B vaccines to improve vaccine immunity
Medchemexpress LLC Biotin-4-aminophenol | 901770-40-9 | 99.45% | C16H21N3O3S | 100 MG
Biotin-4-aminophenol is a biotin-phenol analog that generates free radicals. It conjugates to tyrosine residues in proteins more efficiently and selectively than the previously reported BP1.
- Biotin-phenol analog
- Generates free radicals
- Efficiently conjugates to tyrosine residues in proteins
- More selective than BP1
- Molecular weight: 335.42
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC V-0219 hydrochloride | 2922283-73-4 | 99.39% | C20H26ClF3N4O2 | 25 MG
V-0219 hydrochloride (Compound 9) is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). It can be used for obesity-associated diabetes research.
- Orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R)
- Can be used for obesity-associated diabetes research
- IC50 and target: GLP-1R
Medchemexpress LLC DiAzKs hydrochloride | 2421187-79-1 | 98.0% | 100 MG
DiAzKs hydrochloride, also known as H-L-Photo-lysine hydrochloride, is a diazirine-containing lysine amino acid and a photo-cross-linker. It can be site-selectively incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. This compound acts as a UV light-activated photo-crosslinking probe.
- Site-selective incorporation into proteins.
- Used to crosslink protein-protein interactions in vitro and in living cells.
- Acts as a UV light-activated photo-crosslinking probe.
- Photo-lysine can capture and identify proteins that recognize lysine post-translational modifications (PTMs), including 'readers' and 'erasers' of histone modifications.
Medchemexpress LLC Nefopam (hydrochloride) | 23327-57-3 | 99.9% | 500 MG
Nefopam hydrochloride is a centrally-acting, non-opioid analgesic drug used for the relief of moderate to severe pain. It also targets β-catenin protein levels in mesenchymal cells both in-vitro and in-vivo.
- Functions as a pain reliever for moderate to severe pain.
- Is a non-opioid drug.
- Targets β-catenin protein levels in mesenchymal cells.
Medchemexpress LLC HAIYPRH hydrochloride | 99.97% | 929.46 | 50 MG
HAIYPRH hydrochloride is a targeting ligand that specifically binds to the transferrin receptor (TfR), facilitating the transport of nanocarriers across the blood-brain barrier. It is a heptapeptide investigated for targeting gliomas and enhancing cellular uptake and gene expression in co-delivery systems.
- Specifically binds to transferrin receptor (TfR).
- Mediates transport of nanocarriers across the blood-brain barrier.
- Utilized as a targeting agent for gliomas.
- Enhances cellular uptake and gene expression in co-delivery systems.
- Conjugated to liposomes for ischemic stroke targeting treatment.
eMolecules AstaTech / (R)-1-(35-DICHLOROPHENYL)ETHYLAMINE / 0.25g / 200619803 / SC1347 / 95.000 / 617710-53-9 / MFCD07772552 / 190.070 / C8H9Cl2N
AstaTech / (R)-1-(35-DICHLOROPHENYL)ETHYLAMINE / 0.25g / 200619803 / SC1347 / 95.000 / 617710-53-9 / MFCD07772552 / 190.070 / C8H9Cl2N
Medchemexpress LLC YIL781 hydrochloride | 1640226-17-0 | 99.48% | 445.96 | 25 MG
YIL781 hydrochloride is a potent, orally active ghrelin receptor (GHSR) antagonist. It has been shown to improve glucose homeostasis in rats and effectively inhibits the calcium response induced by ghrelin.
- Potent and orally active ghrelin receptor (GHSR) antagonist.
- Produces a greater improvement in glucose homeostasis in rats.
- Inhibits the calcium response induced by ghrelin with pIC50 values of 7.90 and 8.27.
- For research use only.
Medchemexpress LLC Harmine hydrochloride | 343-27-1 | MFCD00078028 | 248.71 | 1 ML
Harmine hydrochloride, also known as Telepathine hydrochloride, is a natural DYRK inhibitor. It exhibits anticancer and anti-inflammatory activities, and has a high affinity for the 5-HT2A serotonin receptor. It is supplied as a solution in DMSO.
- Natural DYRK inhibitor
- Exhibits anticancer and anti-inflammatory activities
- High affinity for 5-HT2A serotonin receptor
- Supplied in solution for convenience
Medchemexpress LLC CC-115 hydrochloride | 1300118-55-1 | 98.01% | 372.81 | 1 ML
CC-115 hydrochloride is a potent, dual DNA-PK and mTOR kinase inhibitor. It targets both mTORC1 and mTORC2 signaling, making it a valuable tool for research applications. This compound has demonstrated significant inhibitory effects against PC-3 cell proliferation and exhibits good in vivo pharmacokinetic profiles, including high oral bioavailability in various animal models.
- Potent DNA-PK inhibitor (IC50 of 13 nM)
- Potent mTOR kinase inhibitor (IC50 of 21 nM)
- Blocks both mTORC1 and mTORC2 signaling
- Inhibits PC-3 cell proliferation with an IC50 of 138 nM
- Exhibits good in vivo pharmacokinetic profiles
- Demonstrates high oral bioavailability in mouse, rat, and dog
- Sustains inhibition through 24 hours
- Shows tumor volume reductions in vivo studies
Medchemexpress LLC Biotin-4-aminophenol | 901770-40-9 | 99.45% | C16H21N3O3S | 25 MG
Biotin-4-aminophenol is a biotin-phenol analog. It is designed for research use only and generates free radicals that conjugate to tyrosine residues in proteins more efficiently and selectively than previously reported BP1. This product is suitable for various laboratory applications.
- Generates free radicals
- Efficiently conjugates to tyrosine residues in proteins
- More selective than BP1
- For research use only
- White to off-white solid appearance
Medchemexpress LLC AT7519 Hydrochloride | 902135-91-5 | 99.2% | C16H18Cl3N5O2 | 100 MG
AT7519 Hydrochloride is a potent inhibitor of Cyclin-Dependent Kinases (CDKs), exhibiting strong inhibitory activity against CDK1, CDK2, CDK4 to CDK6, and CDK9. It induces dose-dependent cytotoxicity and apoptosis in MM cells and inhibits cell cycle progression in various human tumor cell lines. In preclinical studies, AT7519 Hydrochloride effectively inhibits tumor growth in both human MM and HCT116 xenograft mouse models.
- Potent inhibitor of CDKs (IC50 values range from <10 nM to 210 nM)
- Induces cytotoxicity and apoptosis in MM cells
- Overcomes cytokine and BMSC protective effects
- Inhibits RNA polymerase II CTD phosphorylation and RNA synthesis
- Inhibits cell cycle progression and induces apoptosis in tumor cell lines
- Reduces antiapoptotic protein levels
- Inhibits tumor growth in MM and HCT116 xenograft models
Sigma Aldrich Fine Chemicals Biosciences SKI II >=98% (HPLC), solid | 312636-16-1 | MFCD00733553 | 50MG
SKI II >=98% (HPLC), solid | Purity: >=98% (HPLC) | Mol Wt: 302.78 | 312636-16-1 | MFCD00733553 | 50MG
Medchemexpress LLC Fasudil (hydrochloride) | 105628-07-7 | MFCD00943198 | 100.0% | 327.83 g·mol⁻¹ | C14H18ClN3O2S | 1 ML
Fasudil hydrochloride is a small-molecule Rho-associated kinase (ROCK) inhibitor used in biochemical and cellular research. It inhibits ROCK1/2 and several protein kinases, and acts as a calcium channel antagonist and vasodilator. The compound is supplied as a purified solid or as a ready-to-use 10 mM solution in DMSO (1 mL). Molecular formula C14H18ClN3O2S; molecular weight 327.83 g·mol⁻¹. For research use only - not for human or clinical use.
- Ready-to-use 10 mM solution in DMSO, 1 mL.
- Also available as purified solid in multiple pack sizes.
- High purity (≈99.97%).
- Stable when stored sealed at 4°C; in solution store at -20°C to -80°C.
- Intended for biochemical and cellular assays targeting ROCK signaling.