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Filtered Search Results
Medchemexpress LLC Cathepsin Inhibitor 2 | 1017931-53-1 | 421.38 | 1 ML
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Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor, with a Ki of <20 nM. It also potently inhibits Cathepsin F, Cathepsin L, and Cathepsin B with Kis ranging from 21-500 nM.
- Potent Cathepsin S inhibitor with Ki <20 nM.
- Inhibits Cathepsin F, Cathepsin L, and Cathepsin B with Kis of 21-500 nM.
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eMolecules 3-BROMO-2 2 2-TRIFLUOROACE 5G
5000224932 3-BROMO-2 2 2-TRIFLUOROACE 5G
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eMolecules N-METHYLSARCOSINE 5G
5000224859 N-METHYLSARCOSINE 5G
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Medchemexpress LLC 16α-Hydroxydehydroepiandrosterone-d6 | 97453-29-7 | 80.0% | 310.46 | 1 MG
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16α-Hydroxydehydroepiandrosterone-d6 (16α-Hydroxy-DHEA-d6) is a deuterium-labeled 16α-Hydroxydehydroepiandrosterone, intended for research use only. This compound is valuable as a tracer and an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS. Deuteration, the incorporation of stable heavy isotopes of hydrogen, carbon, and other elements into drug molecules, is increasingly recognized for its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
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Medchemexpress LLC Cariprazine (hydrochloride) | 1083076-69-0 | 99.9% | 463.87 | 5 MG
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Cariprazine hydrochloride is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).
- Exhibits high affinity for D3 and D2 receptors.
- Shows moderate affinity for the 5-HT1A receptor.
- Stimulates inositol phosphate formation with high potency.
- Antagonizes human serotonin 5-HT2B receptors.
- More potent in inhibiting isoproterenol-induced cAMP production than Aripiprazole.
- Reduces striatal uptake of radioligands in vivo.
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Medchemexpress LLC 3-Bromo-5-chloropyridine | 73583-39-8 | 192.44 | 25 G
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3-Bromo-5-chloropyridine is a widely used heterocyclic compound that can be used to synthesize various compounds. It serves as an intermediate in the production of crop protectants within the agricultural chemicals industry and can also participate in cross-coupling reactions.
- Appearance: Off-white to light brown solid
- Consistent with structure based on ¹H NMR spectrum
- Consistent with structure based on MS
- Purity (HPLC): 99.87%
- Water (KF): 0.09%
- Target: Biochemical assay reagents
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Medchemexpress LLC GS-443902 trisodium | 1355050-21-3 | 99.9% | 597.15 | 1 MG
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GS-443902 trisodium is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp). It has IC50 values of 1.1 μM for RSV RdRp and 5 μM for HCV RdRp. This compound is the active triphosphate metabolite of Remdesivir, intended for research use only.
- Potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor
- Active triphosphate metabolite of remdesivir
- Inhibits RSV RdRp-catalyzed RNA synthesis
- Inhibits HCV RdRp-catalyzed RNA synthesis
- Selectively inhibits EBOV replication
- Stable under recommended storage conditions
- Store at -80°C, protect from light, and under nitrogen
- Freshly prepared solutions are recommended due to instability
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000369769 TUG-770 100MG
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Medchemexpress LLC Arbutin (β-Arbutin) | 497-76-7 | 99.8% | 272.25 | 25 G
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Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase and is used as a depigmenting agent. It is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possessing anti-oxidant, anti-inflammatory, and anti-tumor properties.
- Inhibits the viability of B16 murine melanoma cells in a time- and dose-dependent manner.
- Increases the apoptosis rate of B16 murine melanoma cells.
- Exhibits protective effects on isoproterenol-induced cardiac hypertrophy in mice.
- Ameliorates isoproterenol-induced myocardial injury.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000429572 XANTHONE 25G
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Apexbio Technology LLC NPS-1034 1221713-92-3 5mg
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NPS-1034 (CAS 1221713-92-3) is a potent inhibitor of the receptor tyrosine kinase MET with an IC50 of 4 nmol/L MET activated by hepatocyte growth factor is implicated in morphogenesis and tumor progression across various cancers NPS-1034 suppresses cell viability in MET-overexpressing and phosphorylated MET-positive cell lines such as MKN45 and SNU638 with IC50 values of 112 7 nmol/L and 190 3 nmol/L respectively In vivo oral administration of NPS-1034 reduces tumor growth and angiogenesis in MKN45 xenograft models These characteristics support the utility of NPS-1034 in studying MET-driven oncogenic signaling and its therapeutic targeting
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Medchemexpress LLC Cariprazine hydrochloride | 1083076-69-0 | 99.88% | 463.87 | 500 MG
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Cariprazine hydrochloride | 1083076-69-0 | 99.88% | 463.87 | 500 MG
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Apexbio Technology LLC Bazedoxifene HCl 198480-56-7 10mM (in 1mL DMSO)
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Bazedoxifene HCl (198480-56-7) is a non-steroidal selective estrogen receptor modulator (SERM) targeting estrogen receptor subtypes ER and ER It is designed to bind ERs thereby modulating estrogen receptor-mediated signaling pathways Bazedoxifene HCl exerts its biological activity primarily by antagonizing ER -mediated transcriptional activity thereby inhibiting estradiol-induced cell proliferation In cell-based studies Bazedoxifene HCl demonstrates inhibition of cell proliferation in human breast cancer (MCF-7) ovarian (CHO) hepatic (HepG2) and neuronal (GT1-7) cell lines The compound exhibits binding affinities (Ki) of 26 nM for ER and 99 nM for ER Based on these pharmacological properties Bazedoxifene HCl holds research potential in osteoporosis and estrogen receptor-mediated diseases including breast ovarian and uterine cancers
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Medchemexpress LLC Pepsin | 9001-75-6 | 25 G
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Pepsin is the major pig and human gastric protease, also described as a pepsin-like minor gastric proteolytic enzyme. It contributes to the proteolysis of food proteins in the vertebrate stomach.
- Enzyme activity: >3000 U/mg solid
- Optimal pH: 1.0-3.0
- Activators: Hydrochloric acid (HCl), trifluoroacetic acid (TFA)
- Inactivators: pH greater than 6.0
- Solubility: ≥ 2 mg/mL in 0.01 M HCl
- Resuspend in double-distilled water (pH 5.5 or lower) to a final concentration of 1 mg/mL
- Store reconstituted Pepsin at 4 °C for up to 1 month
- Specificity for cleavage at Phe and Leu is best at pH 1.0 and decreased above pH 2.0
- Irreversibly inactivates above pH 6.0
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eMolecules /--1 1-BINAPHTHALENE 250G
5000163105 /--1 1-BINAPHTHALENE 250G
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