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Filtered Search Results
Medchemexpress LLC PI3Kγ inhibitor AZ2 | 2231760-33-9 | 99.25% | 369.48 | 1 ML
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PI3Kγ inhibitor AZ2 is a highly selective PI3Kγ inhibitor for research into inflammatory and immune diseases.
- Highly selective PI3Kγ inhibitor (pIC50 = 9.3 for PI3Kγ)
- Suitable for research on inflammatory and immune diseases
- Excellent selectivity for PI3Kγ confirmed in SKOV-3 cells (0.1-100 nM; 1 hour) with a constitutively activated PI3K/Akt pathway
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Medchemexpress LLC Allylthiourea | 109-57-9 | 100.0% | 500 G
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Allylthiourea selectively inhibits the oxidation of ammonia and is commonly used to inhibit nitrification by targeting ammonia monooxygenase and chelating copper in the active site to suppress its activity. It also exhibits anticancer activity, showing cytotoxicity against the MCF-7 cell line with an IC50 of 5.22 mM.
- Selectively inhibits ammonia oxidation
- Inhibits nitrification by targeting ammonia monooxygenase
- Chelates copper in the active site to suppress activity
- Exhibits anticancer activity against MCF-7 cell line (IC50 of 5.22 mM)
- Used in research for micropollutant biodegradability
- Used in cancer studies
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Medchemexpress LLC Loxoprofen sodium | 80382-23-6 | 99.6% | 1 ML
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Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. It is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. It can also reduce atherosclerosis and shows antitumor activity.
- Non-steroidal, orally active anti-inflammatory agent
- Analgesic and anti-pyretic properties
- Nonselective COX inhibitor
- Reduces atherosclerosis
- Shows antitumor activity
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Medchemexpress LLC 9-ING-41 (Elraglusib) | 1034895-42-5 | 99.1% | 404.35 | 1 ML
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9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor. With an IC50 of 0.71 μM, it leads to cell cycle arrest, autophagy, and apoptosis in cancer cells. This compound exhibits significant anticancer activity and has the potential to enhance the antitumor effects of various chemotherapeutic agents.
- Maleimide-based ATP-competitive and selective GSK-3β inhibitor
- Induces cell cycle arrest
- Promotes autophagy
- Induces apoptosis in cancer cells
- Exhibits anticancer activity
- Enhances antitumor effects of chemotherapeutic agents
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Medchemexpress LLC Bethanechol (chloride) | 590-63-6 | 99.6% | 5 G
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Bethanechol chloride acts as a parasympathomimetic agent and a mAChR agonist, directly stimulating all five muscarinic acetylcholine receptor subtypes (M1-M5) within the parasympathetic nervous system. Primarily for research use, this compound has demonstrated significant reduction in ileal pacemaker potentials in vitro. In vivo studies reveal that Bethanechol can induce drinking and increase urine output in rats in a dose-dependent manner. It has a molecular weight of 196.68 and a chemical formula of C7H17ClN2O2, presenting as a white to off-white solid. It exhibits solubility in water (≥ 50 mg/mL) and DMSO (11.11 mg/mL).
- Directly stimulates mAChR (M1, M2, M3, M4, and M5)
- Significantly reduces ileal pacemaker potentials in vitro
- Induces drinking and increases urine output in rats in vivo
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Medchemexpress LLC Rabeprazole sodium | 117976-90-6 | 99.9% | 1 ML
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Rabeprazole sodium (LY307640 sodium) is provided as a 10 mM solution in 1 mL of DMSO. It is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. This compound induces apoptosis and acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. It is suitable for research on gastric ulcerations and gastroesophageal reflux and is intended for research use only.
- Second-generation proton pump inhibitor (PPI)
- Irreversibly inactivates gastric H+/K+-ATPase
- Induces apoptosis
- Acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM
- Suitable for research on gastric ulcerations and gastroesophageal reflux
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Medchemexpress LLC 2-Methoxyestrone-d4 | 949885-90-9 | 98.0% | 304.42 | 1 MG
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2-Methoxyestrone-d4 is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81. It can be used as a tracer or an internal standard for quantitative analysis.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
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Medchemexpress LLC N-Methylhydantoin | 616-04-6 | 99.9% | 114.10 | 5 G
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N-Methylhydantoin is a product of degradation of creatinine by bacteria. It is for research use only and not sold to patients.
- Endogenous metabolite
- Microbial metabolite
- Shipping at room temperature in continental US; may vary elsewhere
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
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eMolecules 14221-01-3 | Tetrakis(triphenylphosphine)palladium | Apollo Scientific | MFCD00010012 | 1155.590 | C72H60P4Pd | 95.000 | [Pd].c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1 | 25g | 562438113
Tetrakis(triphenylphosphine)palladium | Apollo Scientific | 14221-01-3 | MFCD00010012 | 1155.590 | C72H60P4Pd | 95.000 | [Pd].c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1 | 25g | 562438113
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Medchemexpress LLC Olopatadine hydrochloride | 140462-76-6 | 99.8% | 50 MG
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Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis and other allergic disorders. It significantly inhibits ear swelling and the production of several interleukins. It is rapidly absorbed, with renal clearance, and has shown effectiveness in treating allergic rhinitis and chronic urticaria in clinical trials.
- Used to treat allergic conjunctivitis
- Second-generation histamine H1 receptor antagonist
- Significantly inhibits ear swelling
- Increases production of IL-4, IL-1beta, IL-6, GM-CSF, and NGF
- Highly and rapidly absorbed in healthy human volunteers
- Renal clearance drug
- Useful for treating allergic rhinitis and chronic urticaria
- Inhibits histamine release from human conjunctival mast cells
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Medchemexpress LLC Cefmenoxime (hydrochloride) | 75738-58-8 | 99.3% | 1 G
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Cefmenoxime hydrochloride is a new semisynthetic cephalosporin antibiotic, effective against a wide range of gram-positive and gram-negative bacteria.
- Molecular weight: 529.79
- Chemical formula: C16H17.5Cl0.5N9O5S3
- Appearance: White to yellow solid
- Storage: 4°C, sealed, away from moisture
- In solvent storage: -80°C for 6 months; -20°C for 1 month
- Soluble in DMSO (65 mg/mL), insoluble in water
- Inhibits at least 90% of tested strains (MIC90) from 0.06 to 8 μg/mL for Enterobacteriaceae
- Effective against Haemophilus influenzae, Neisseria gonorrhoeae, and Neisseria meningitidis
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eMolecules 126-38-5 | 1-Bromo-2,2-dimethoxypropane | Combi-Blocks | MFCD00000208 | 183.045 | C5H11BrO2 | 97.000 | COC(C)(CBr)OC | 1g | 517025904
1-Bromo-2,2-dimethoxypropane | Combi-Blocks | 126-38-5 | MFCD00000208 | 183.045 | C5H11BrO2 | 97.000 | COC(C)(CBr)OC | 1g | 517025904
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eMolecules 32315-10-9 | Triphosgene | AA Blocks LLC | MFCD00062848 | 296.730 | C3Cl6O3 | 0.000 | ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl | 100g | 410168143
Triphosgene | AA Blocks LLC | 32315-10-9 | MFCD00062848 | 296.730 | C3Cl6O3 | 0.000 | ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl | 100g | 410168143
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eMolecules 91-15-6 | 1,2-Benzenedicarbonitrile | AA Blocks LLC | MFCD00001771 | 128.134 | C8H4N2 | 0.000 | N#Cc1ccccc1C#N | 25g | 486443634
1,2-Benzenedicarbonitrile | AA Blocks LLC | 91-15-6 | MFCD00001771 | 128.134 | C8H4N2 | 0.000 | N#Cc1ccccc1C#N | 25g | 486443634
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Medchemexpress LLC Bromo-PEG2-phosphonic acid diethyl ester | 1226767-94-7 | C10H22BrO5P | 100 MG
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Bromo-PEG2-phosphonic acid diethyl ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound facilitates the creation of bifunctional molecules that leverage the ubiquitin-proteasome system to degrade target proteins.
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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