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Filtered Search Results
Apexbio Technology LLC HATU 148893-10-1 1kg
HATU (1-[Bis(dimethylamino)methylene]-1H-1 2 3-triazolo[4 5-b]pyridinium 3-oxid hexafluorophosphate) is a peptide coupling reagent routinely employed for amide-bond formation in peptide synthesis and other biomolecular applications In solution HATU converts carboxylic acids into active ester intermediates (OAt esters) facilitating subsequent nucleophilic attack from amines or alcohols This reaction typically proceeds in presence of basic additives such as N N-Diisopropylethylamine (DIPEA) under anhydrous conditions in solvents like dimethylformamide (DMF) Its utility extends to synthesizing peptides and modifying biomolecules through ester or amide linkage formation widely applied in biomedical research and pharmaceutical laboratories
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Apexbio Technology LLC Nonivamide (Capsaicin Analog) 2444-46-4 10mM (in 1mL DMSO)
Nonivamide (CAS 2444-46-4) a structural analog of capsaicin found in chili peppers is an agonist of the transient receptor potential vanilloid subtype 1 (TRPV1) a thermally activated calcium ion channel Binding of nonivamide to TRPV1 lowers the channel activation threshold below physiological temperature altering cellular calcium influx Related compounds have demonstrated notable antiproliferative effects triggering apoptosis through pathways involving downregulation of anti-apoptotic Bcl-2 proteins activation of caspases mitochondrial dysfunction and differentiation induction in diverse cancer cell lines including glioma and breast cancer cells As a result of these properties nonivamide serves as a valuable tool for investigating TRPV1-mediated signaling and anticancer mechanisms in biomedical research
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Apexbio Technology LLC HyperChrom SP HP Agarose 10ml
HyperChrom SP HP Agarose is a strong cation-exchange chromatography resin designed for bioseparation applications based on differences in molecular charge properties Employing a highly cross-linked agarose matrix this resin enables efficient separation of biological molecules such as recombinant proteins antibodies nucleic acids viruses virus-like particles and polysaccharides The chemically modified agarose backbone enhances rigidity allowing high flow rates under reduced backpressure facilitating streamlined scalable purification processes suitable for biomedical research and biopharmaceutical production
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Apexbio Technology LLC Tranylcypromine hydrochloride 1986-47-6 10mM (in 1mL DMSO)
Tranylcypromine hydrochloride (CAS 1986-47-6) is a small molecule inhibitor that irreversibly targets monoamine oxidase (MAO) isoforms A and B demonstrating mechanism-based inhibition with Ki values of 101 9 M for MAO A and 16 M for MAO B and corresponding IC50 values of 2 3 M and 0 95 M Additionally tranylcypromine acts as a time-dependent irreversible inhibitor of lysine-specific demethylase 1 (LSD1) an amine oxidase homolog with structural similarities to MAOs exhibiting a Ki of 242 M and an IC50 of 20 7 M This compound is widely utilized in studies investigating MAO and LSD1 enzymatic functions epigenetic regulation and monoamine metabolism
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Apexbio Technology LLC NPS-1034 1221713-92-3 5mg
NPS-1034 (CAS 1221713-92-3) is a potent inhibitor of the receptor tyrosine kinase MET with an IC50 of 4 nmol/L MET activated by hepatocyte growth factor is implicated in morphogenesis and tumor progression across various cancers NPS-1034 suppresses cell viability in MET-overexpressing and phosphorylated MET-positive cell lines such as MKN45 and SNU638 with IC50 values of 112 7 nmol/L and 190 3 nmol/L respectively In vivo oral administration of NPS-1034 reduces tumor growth and angiogenesis in MKN45 xenograft models These characteristics support the utility of NPS-1034 in studying MET-driven oncogenic signaling and its therapeutic targeting
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Apexbio Technology LLC NPS-1034 1221713-92-3 10mg
NPS-1034 (CAS 1221713-92-3) is a potent inhibitor of the receptor tyrosine kinase MET with an IC50 of 4 nmol/L MET activated by hepatocyte growth factor is implicated in morphogenesis and tumor progression across various cancers NPS-1034 suppresses cell viability in MET-overexpressing and phosphorylated MET-positive cell lines such as MKN45 and SNU638 with IC50 values of 112 7 nmol/L and 190 3 nmol/L respectively In vivo oral administration of NPS-1034 reduces tumor growth and angiogenesis in MKN45 xenograft models These characteristics support the utility of NPS-1034 in studying MET-driven oncogenic signaling and its therapeutic targeting
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Apexbio Technology LLC Adiphenine HCl 50-42-0 10mM (in 1mL DMSO)
Adiphenine hydrochloride (CAS 50-42-0) is a small molecule that functions as an inhibitor of nicotinic acetylcholine receptors By antagonizing these receptors Adiphenine hydrochloride disrupts cholinergic neurotransmission at autonomic ganglia and neuromuscular junctions This activity underlies its utility as an antispasmodic agent where it modulates smooth muscle contraction in physiological and pharmacological studies Adiphenine hydrochloride is utilized in biomedical research to investigate nicotinic receptor signaling pathways and to explore mechanisms underlying smooth muscle relaxation
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Apexbio Technology LLC NPS-1034 1221713-92-3 25mg
NPS-1034 (CAS 1221713-92-3) is a potent inhibitor of the receptor tyrosine kinase MET with an IC50 of 4 nmol/L MET activated by hepatocyte growth factor is implicated in morphogenesis and tumor progression across various cancers NPS-1034 suppresses cell viability in MET-overexpressing and phosphorylated MET-positive cell lines such as MKN45 and SNU638 with IC50 values of 112 7 nmol/L and 190 3 nmol/L respectively In vivo oral administration of NPS-1034 reduces tumor growth and angiogenesis in MKN45 xenograft models These characteristics support the utility of NPS-1034 in studying MET-driven oncogenic signaling and its therapeutic targeting
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Apexbio Technology LLC Antazoline HCl 2508-72-7 10mM (in 1mL DMSO)
Antazoline hydrochloride (CAS 2508-72-7) is a first-generation antihistamine that acts as a competitive antagonist at the histamine H1 receptor By occupying the H1 binding site Antazoline HCl prevents endogenous histamine from eliciting its effects thereby inhibiting downstream signaling pathways associated with allergic responses This compound is frequently utilized in pharmacological studies to investigate histaminergic signaling allergy mechanisms and the physiological role of H1 receptor modulation in various in vitro and in vivo models
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Apexbio Technology LLC Ticlopidine HCl 53885-35-1 5g
Ticlopidine HCl is a small-molecule inhibitor targeting the platelet P2Y purinergic receptor subtype It is designed to inhibit platelet aggregation by blocking the interaction of extracellular adenosine diphosphate (ADP) with its receptor thereby suppressing ADP-induced signaling pathways essential for platelet activation Ticlopidine HCl exerts its biological activity primarily through selective inhibition of ADP-driven platelet responses It demonstrates inhibitory activity with an IC50 of approximately 2 M Based on these pharmacological properties Ticlopidine HCl holds research potential in studies of platelet activation mechanisms thrombotic disease modeling and evaluation of therapeutic approaches targeting ADP-mediated platelet signaling pathways
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Apexbio Technology LLC Ro 106-9920 62645-28-7 1mg
Ro 106-9920 (CAS 62645-28-7) is a small molecule inhibitor that selectively suppresses the activation of the NF-kappaB signaling pathway By interfering with NF-kappaB function Ro 106-9920 modulates transcriptional events involved in cellular inflammatory responses survival and tumor progression Aberrant NF-kappaB activity is frequently observed in various cancer cell types and is linked to enhanced proliferation invasion and resistance to apoptosis Ro 106-9920 is widely utilized in cellular and animal studies to investigate the roles of NF-kappaB in oncogenesis and related pathologies providing a valuable tool for elucidating NF-kappaB-mediated mechanisms and evaluating potential therapeutic strategies
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Apexbio Technology LLC Ivabradine HCl 148849-67-6 10mM (in 1mL DMSO)
Ivabradine hydrochloride (CAS 148849-67-6) is a selective inhibitor of the If (funny) current in sinoatrial node cells By targeting the If channel Ivabradine reduces cardiac pacemaker activity leading to a dose-dependent decrease in heart rate without affecting myocardial contractility In vitro studies report an IC50 of 2 9 M for inhibition of the If current Owing to its specific action on heart rate modulation Ivabradine HCl is widely utilized in preclinical research investigating cardiac electrophysiology autonomic regulation and the development of heart rate lowering agents
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Apexbio Technology LLC Gabapentin HCl 60142-95-2 20mg
Gabapentin HCl (CAS 60142-95-2) is a structurally related analog of gamma-aminobutyric acid (GABA) though it does not bind directly to GABA receptors Its primary mechanism involves binding to the 2 subunit of voltage-gated calcium channels in neuronal tissues resulting in decreased neurotransmitter release Originally investigated for antiepileptic properties gabapentin has been widely utilized in research exploring neuropathic pain modulation and neuronal excitability This molecule serves as a tool compound for studying calcium channel modulation and the pathophysiology of neurological disorders
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Apexbio Technology LLC Benserazide HCl 14919-77-8 10mM (in 1mL DMSO)
Benserazide HCl is a small-molecule inhibitor targeting aromatic L-amino acid decarboxylase (AADC) It is designed to inhibit peripheral AADC activity thereby reducing dopamine synthesis outside the central nervous system and facilitating increased availability of administered levodopa to the brain Benserazide HCl exerts its biological activity primarily through selective inhibition of peripheral AADC In experimental research it is frequently combined with levodopa to investigate dopamine metabolism and neural transmission pathways Based on these pharmacological properties Benserazide HCl holds research potential in studies involving neurodegenerative disease models particularly Parkinson s disease to explore dopaminergic system dynamics and therapeutic mechanisms
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Apexbio Technology LLC Procainamide HCl 614-39-1 10mM (in 1mL DMSO)
Procainamide hydrochloride (CAS 614-39-1) is a small molecule that functions as an inhibitor of DNA methyltransferase 1 (DNMT1) modulating DNA methylation patterns and thereby restoring the expression of tumor suppressor genes This activity has been associated with suppression of cell proliferation and migration as well as the induction of cellular vacuolization Additionally Procainamide hydrochloride has been shown to enhance potassium channel activity contributing to the regulation of smooth muscle relaxation It is commonly employed in biomedical research focused on epigenetic mechanisms in oncology and studies of cardiac arrhythmias
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