Benzyl Derivatives
Apexbio Technology LLC Doxylamine Succinate 562-10-7 50mg
Doxylamine succinate (CAS 562-10-7) is a first-generation antihistamine that acts as a competitive antagonist at histamine H1 receptors By blocking these receptors it effectively prevents histaminergic signaling leading to pronounced sedative and anticholinergic effects In biomedical research doxylamine succinate is utilized to investigate histaminergic pathways study the pharmacology of H1 receptor antagonists and explore mechanisms underlying sedation and anticholinergic activity Its well-characterized mode of action makes it a valuable reference compound in studies on allergic responses sleep physiology and receptor-ligand interactions
Research Products International Corp Miconazole Nitrate, 5 Grams
Miconazole Nitrate is an antifungal medication. It belongs to the class of azole antifungal agents and is used to combat various fungal infections. It works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes. Without sufficient ergosterol, the integrity of the fungal cell membrane is compromised, leading to cell death.
In research and laboratory settings, miconazole nitrate may be used as a tool to study fungal biology and the mechanisms of antifungal action. Researchers may explore its efficacy against specific fungal strains and its impact on fungal cell structures and functions.
Apexbio Technology LLC PA-824(Synonyms: Pretomanid, Nitroimidazooxazine, PA824, Pretomanide), 10mM (in 1mL DMSO), CAS: 187235-37-6.
PA-824 (CAS 187235-37-6) is a bicyclic nitroimidazole derivative exhibiting antimycobacterial activity against Mycobacterium tuberculosis Its bactericidal mechanism entails inhibition of ketomycolate biosynthesis and enzymatic nitro-reduction leading to intracellular release of nitric oxide killing both replicating and non-replicating M tuberculosis Reported MIC values range from 0 015 g/ml to 0 25 g/ml PA-824 demonstrates activity against drug-sensitive and drug-resistant tuberculosis strains supporting its utility in tuberculosis research and therapeutic investigations
Apexbio Technology LLC PA-824(Synonyms: Pretomanid, Nitroimidazooxazine, PA824, Pretomanide), 100mg, CAS: 187235-37-6.
PA-824 (CAS 187235-37-6) is a bicyclic nitroimidazole derivative exhibiting antimycobacterial activity against Mycobacterium tuberculosis Its bactericidal mechanism entails inhibition of ketomycolate biosynthesis and enzymatic nitro-reduction leading to intracellular release of nitric oxide killing both replicating and non-replicating M tuberculosis Reported MIC values range from 0 015 g/ml to 0 25 g/ml PA-824 demonstrates activity against drug-sensitive and drug-resistant tuberculosis strains supporting its utility in tuberculosis research and therapeutic investigations
Apexbio Technology LLC PA-824(Synonyms: Pretomanid, Nitroimidazooxazine, PA824, Pretomanide), 5mg, CAS: 187235-37-6.
PA-824 (CAS 187235-37-6) is a bicyclic nitroimidazole derivative exhibiting antimycobacterial activity against Mycobacterium tuberculosis Its bactericidal mechanism entails inhibition of ketomycolate biosynthesis and enzymatic nitro-reduction leading to intracellular release of nitric oxide killing both replicating and non-replicating M tuberculosis Reported MIC values range from 0 015 g/ml to 0 25 g/ml PA-824 demonstrates activity against drug-sensitive and drug-resistant tuberculosis strains supporting its utility in tuberculosis research and therapeutic investigations
Apexbio Technology LLC PA-824(Synonyms: Pretomanid, Nitroimidazooxazine, PA824, Pretomanide), 25mg, CAS: 187235-37-6.
PA-824 (CAS 187235-37-6) is a bicyclic nitroimidazole derivative exhibiting antimycobacterial activity against Mycobacterium tuberculosis Its bactericidal mechanism entails inhibition of ketomycolate biosynthesis and enzymatic nitro-reduction leading to intracellular release of nitric oxide killing both replicating and non-replicating M tuberculosis Reported MIC values range from 0 015 g/ml to 0 25 g/ml PA-824 demonstrates activity against drug-sensitive and drug-resistant tuberculosis strains supporting its utility in tuberculosis research and therapeutic investigations
Medchemexpress LLC Linoleyl alcohol | 506-43-4 | 266.46 | 1 G
Linoleyl alcohol is a fatty alcohol, a structural analog of Linoleic acid that lacks an α-carboxyl group. It is intended for research use only and has been shown to be effective in weight-loss promotion and metabolic syndrome management in animal studies.
- Fatty alcohol, structural analog of linoleic acid
- Lacks an α-carboxyl group
- Used in research applications
- Dioxygenation by potato tuber lipoxygenase leads to the formation of hydroperoxyoctadecadien-1-ols
- Esters with Gallic acid and (-)-Epigallocatechin promote weight loss and metabolic syndrome management in animal models
Medchemexpress LLC SHIN1 (RZ-2994) | 2146095-85-2 | 98.6% | 400.47 | 100 MG
SHIN1 (RZ-2994) is a human serine hydroxymethyltransferase 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. It is for research use only and not sold to patients.
- Inhibits human SHMT1/2 with IC50s of 5 nM (SHMT1) and 13 nM (SHMT2) in an in vitro assay.
- Inhibits the growth of SHMT2 deletion HCT-116 cells with an IC50 of 10 nM.
- Particularly active against B-cell malignancies.
- Blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates.
Medchemexpress LLC Phospho-NF-KB p65 (Ser536) Antibody | 50 UL
This antibody is a rabbit-derived, non-conjugated IgG polyclonal antibody designed to target Phospho-NF-KB p65 (Ser536). It is suitable for a variety of applications including Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), and Immunocytochemistry/Immunofluorescence (ICC/IF), reacting with human, mouse, and rat samples.
- Rabbit-derived host
- Non-conjugated IgG polyclonal antibody
- Verified for Western Blot, IHC-P, and ICC/IF applications
- Concentration of 1 mg/mL
- Formulated in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA with 0.02% sodium azide
- Stable for 1 year when stored at -20°C
- Avoids repeated freeze/thaw cycles to maintain stability
- Shipped with blue ice
Medchemexpress LLC Phospho-NF-KB p65 (Ser536) Antibody | 10 UL
Phospho-NF-KB p65 (Ser536) Antibody is a Rabbit-derived, non-conjugated IgG polyclonal antibody specifically targeting Phospho-NF-KB p65 (Ser536). This antibody is for research use only and is supplied in 1*PBS (pH 7.3), 50% glycerol, and 0.5% BSA, with 0.02% sodium azide as a preservative.
- Host: Rabbit
- Clonality: Polyclonal
- Isotype: IgG
- Modification: Phosphorylated
- Purity: Affinity purified
- Predicted molecular weight: 60 kDa
- Observed molecular weight: 65 kDa
- Species reactivity: Human, mouse, rat
- Applications: Western blot (1:500-1:1000), immunohistochemistry-paraffin (1:50-1:100), immunocytochemistry/immunofluorescence (1:50-1:200)
Medchemexpress LLC Phospho-NF-KB p65 (Ser536) Antibody | 100 UL
Phospho-NF-KB p65 (Ser536) Antibody is a rabbit-derived, non-conjugated IgG polyclonal antibody designed to target Phospho-NF-KB p65 (Ser536). NF-kappa-B is a crucial transcription factor involved in various biological processes including inflammation, immunity, differentiation, cell growth, and apoptosis.
- Host: Rabbit
- Clonality: Polyclonal
- Reactivity: Human, Mouse, Rat
- Conjugation: Non-conjugated
- Isotype: IgG
- Modification: Phosphorylated
- Formulation: Supplied in 1*PBS (pH 7.3), 50% glycerol, 0.5% BSA, and 0.02% sodium azide
- Appearance: Liquid
- Storage & stability: Stored at -20°C for 1 year; avoid repeated freeze/thaw cycles
- Sensitivity: Endogenous
- Applications: WB, IHC-P, ICC/IF
Medchemexpress LLC NF-KB p105/p50 Antibody (YA699) | Protein L affinity purified | Predicted band size: 105 kDa; Observed band size: 50/120 kDa | 50 UL
The NF-KB p105/p50 Antibody (YA699) is a Mouse-derived, non-conjugated IgM monoclonal antibody designed for research use. It targets NF-KB p105/p50, a pleiotropic transcription factor involved in various biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis, and apoptosis.
- Host: Mouse
- Clonality: Monoclonal
- Molecular weight: Predicted 105 kDa; Observed 50/120 kDa
- Species reactivity: Human, mouse
- Purity: Protein L affinity purified
- Conjugation: Non-conjugated
- Isotype: IgM
- Formulation: Supplied in 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol, 0.05% Sodium Azide
- Appearance: Liquid
- Applications: WB (1:1000-1:2000), ICC/IF (1:200), IHC-P (1:200-1:500)
- Storage and stability: Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Medchemexpress LLC Phospho-NF-KB p65 (Thr254) Antibody | 10 UL
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. The most abundant form of NF-kappa-B is NFKB1 complexed with RELA.
- Rabbit-derived, non-conjugated IgG polyclonal antibody
- Targets Phospho-NF-KB p65 (Thr254)
- Reactivity: Human, mouse, rat
- SwissProt ID: Q04206
- Research field: Cell biology
- Formulation: Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA with 0.02% sodium azide
- Appearance: Liquid
- Applications: WB (1:500-1:1000), IHC-P (1:50-1:100), ICC/IF (1:50-1:200)
- Storage: Stored at -20°C for 1 year, avoid repeated freeze/thaw cycles
- Shipping: Shipped with blue ice