Apexbio Technology LLC PA-824 5MG
PA-824 (CAS 187235-37-6) is a bicyclic nitroimidazole derivative exhibiting antimycobacterial activity against Mycobacterium tuberculosis Its bactericidal mechanism entails inhibition of ketomycolate biosynthesis and enzymatic nitro-reduction leading to intracellular release of nitric oxide killing both replicating and non-replicating M tuberculosis Reported MIC values range from 0 015 g/ml to 0 25 g/ml PA-824 demonstrates activity against drug-sensitive and drug-resistant tuberculosis strains supporting its utility in tuberculosis research and therapeutic investigations