Sera
Cayman Chemical (±)-Salsolinol (hydrochloride), Purity: ≥99%, CAS: 79923-51-6, 100 mg
A metabolite of ethanol produced in the brain that stimulates dopamineric neurons at 0.1 μM
Cayman Chemical R S-natbIntartrate 100mg
A minor tobacco alkaloid; an agonist of α4β2 and α6/α3β2β4 subunit-containing nAChRs (EC50s = 6.1 and 3.6 µM, respectively); selective for these nAChRs over α3β4 subunit-containing nAChRs or α7 nAChRs (EC50s = 70.6 and 158.5 µM, respectively); stimulates dopamine release from isolated rat brain synaptosomes (EC50s = 1.76 and >100 µM, respectively); has anxiolytic-like activity in zebrafish at 10 mg/L; decreases disease severity in a mouse model of thyroglobulin, CFA, and M. tuberculosis immunization-induced moderate experimental autoimmune thyroiditis; decreases food and nicotine self-administration in monkeys (ED50s = 2.085 and 0.854 mg/kg, respectively); has been used as a biomarker of tobacco use
Cayman Chemical SCH 23390 (hydrochloride), Purity: ≥99%, CAS: 125941-87-9, 50 mg
A selective antagonist of the dopamine D1-like receptor subtypes D1 and D5 (Kis = 0.2 and 0.3 nM, respectively); useful for studying the role of the dopamine system in normal brain function and neurological disorders
Cayman Chemical TMPyP4 (tosylate), Purity: ≥95%, CAS: 36951-72-1, 100 mg
A cationic porphyrin that intercalates into and stabilizes G-quadruplexes; inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo
Cayman Chemical Balsalazide, Purity: ≥98%, CAS: 80573-04-2, 50 mg
A prodrug form of 5-ASA; cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA; decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of DNCB-induced colitis at 600 mg/kg per day
Cayman Chemical Latanoprost, Purity: ≥98%, CAS: 130209-82-4, 50 mg
An FP receptor agonist and prodrug of latanoprost (free acid); induces phosphoinositide turnover in isolated human ciliary muscle and human trabecular meshwork cells, HEK293 cells expressing human ocular FP receptors, mouse NIH3T3 fibroblasts, and rat A7r5 vascular smooth muscle cells (EC50s = 313, 564, 173, 142, and 110 nM, respectively); topical ocular application reduces IOP in cynomolgus monkeys in a model of laser-induced glaucoma at 0.005% twice per day
Cayman Chemical Clotrimazole, Purity: ≥98%, CAS: 23593-75-1, 100 mg
An imidazole antifungal; tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and disturbs the fungal cell membrane; inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC50 = 6.0 and 0.07 µM, respectively) in mammalian cells
Cayman Chemical (S)-10-hydroxy-Camptothecin, Purity: ≥98%, CAS: 19685-09-7, 50 mg
An inhibitor of topoisomerase I that demonstrates less toxicity than its parent compound; demonstrates strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM)
Cayman Chemical (−)-Apomorphine (hydrochloride hydrate), Purity: ≥95%, CAS: 58117-94-5, 50 mg
A non-selective dopamine receptor agonist (pKis = 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively); produces biphasic effects on locomotor activity and displays anti-Parkinsonian and neuroprotective actions
Cayman Chemical GunosIn 5-trIphosphateso 50mg
A substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication; participates in G-protein-related signal transduction where it is converted to GDP through the action of GTPases
Cayman Chemical Clemastine (fumarate), Purity: ≥98%, CAS: 14976-57-9, 100 mg
A histamine H1 receptor antagonist (Ki = 0.26 nM); selective for the histamine H1 receptor over mAChRs (Ki = 16 nM), as well as over σ1 and σ2 and α2A-, α2B-, and α2C-adrenergic receptors (Kis = 67, 15, 1,365, 691, and 545 nM, respectively); reduces ovalbumin-induced bronchial obstruction in ovalbumin-sensitized guinea pigs alone or in combination with cimetidine at 0.12 mg/kg; decreases SARS-CoV-2 replication in SARS-CoV-2-infected Vero E6 cells (EC50 = 0.95 µM)
Cayman Chemical (±)-Taxifolin, Purity: ≥98%, CAS: 24198-97-8, 100 mg
A flavonoid with diverse biological activities; scavenges DPPH radicals in cell-free assays; cytotoxic to HCT116 cells (IC50 = 63.42 µM); inhibits HMG-CoA reductase activity and cholesterol synthesis in HepG2 cells at 200 µM; reduces carrageenan-induced paw edema in rats (ED50 = 12.9 mg/kg)
Cayman Chemical Fenretinide, Purity: ≥98%, CAS: 65646-68-6, 50 mg
An inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM); promotes the generation of ROS, degradation of MCL-1, and cleavage of PKCδ; selectively activates RARγ at 5-20 µM; inhibits the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells (IC50s = 3.7, 6.9, and 8.2 µM, respectively); increases activity of SPT by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM); prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle; reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription at 10 mg/ml
Sino Biological Cynomolgus / Rhesus CD64/FCGR1 Protein (His Tag)
A DNA sequence encoding the Cynomolgus, Rhesus FCGR1 (F7BDL2) (Gln18-Pro288) was expressed with a polyhistidine tag at the C-terminus. The sequences of A0A2K5U901 (Cynomolgus) (Gln33–Pro305) and F7BDL2 (Rhesus macaque) (Gln18–Pro288) are identical.