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Human sera and related serum-derived preparations are used in cell culture, immunoassays, and other laboratory research. Depending on the preparation, they may supplement culture media or serve as blocking reagents and assay controls.
A fluorogenic substrate for α-glucosidase; is cleaved by α-glucosidase to release the fluorescent moiety 4-MU; ex = 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively; em = 445 to 455 nm, increasing as pH decreases; has been used to quantify α-glucosidase activity in infant blood spot samples in the diagnosis of Fabry and Pompe diseases
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A B1- and B2-AR antagonist (Kis 2.6 and 4.8 nM respectively) partial agonist of the B3-AR antagonist of the 5-HT1A receptor (Ki 81.1 nM for inhibition of 5-HT-stimulated GTPYS binding) inhibits isoproterenol-induced tachycardia in anesthetized cats (ED50 1.8 Ug/kg) decreases mean blood pressure in conscious spontaneously hypertensive rats at 30 mg/kg per day
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A third-generation heterocyclic nitrogen-containing bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption; has a high affinity for hydroxyapatite (Ki = 3.47 μM) and binds directly to mineralized bone where it decreases bone resorption by inhibiting osteoclast proliferation and inducing osteoclast apoptosis
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An antihistamine with anticholinergic and antiserotonergic activities; histamine H1 receptor antagonist (Ki = 3.9 nM); inhibits histamine- and acetylcholine-induced contractions in isolated guinea pig ilium and 5-HT-induced contractions in isolated rat uterus (EC50s = 6.5, 10, and 14 nM, respectively); delays the onset of dyspnea induced by aerosolized histamine, 5-HT, or acetylcholine in guinea pigs; prevents histamine-induced lethality in guinea pigs and paw edema in mice (ED50s = 9 and 68 μg/kg, respectively); increases survival in guinea pig and mouse models of anaphylactic shock (PD50s = 0.024 and 0.019 mg/kg, respectively)
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A β-glucuronidase chromogenic substrate; upon cleavage by β-glucuronidase, an insoluble salmon precipitate is formed that can be used in histochemical analysis of β-glucuronidase activity
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An analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Kis = 5.3 and 330 nM, respectively); significantly reduces phlorizin-sensitive sugar transport in COS-1 cells expressing human SGLT2
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Butterfield's Phosphate Buffer (BPB), pH 7.2, is utilized as a diluent in the preparation of sample dilutions and microbiological suspensions in laboratory processes. • Product meets AOAC, APHA, ASM, BAM, SM-Dairy, SMWW, Harmonized USP/EP/JP, and USDA reference methods and performance criteria.• Butterfield's Phosphate Buffer should be used by trained professionals within a laboratory setting. • Product is not intended for use in the diagnosis or treatment of disease or other human conditions.• Also known as Phosphate Buffer, pH 7.2, and Butterfield's Phosphate Buffered Dilution Water.
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An atypical antipsychotic drug that displays high affinity for histamine (H), serotonin (5-HT), dopamine (D), and α1-adrenergic receptors (Ki values are 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A, respectively)
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A plant growth regulator; stimulates fruit growth, as well as increases fruit size and ripening rate, in kiwifruit when applied topically at 40 mg/L; accelerates fruit growth and increases rind thickness in watermelons
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