Goat Secondary Antibodies
Cayman Chemical Pramoxine (hydrochloride), Purity: ≥98%, CAS: 637-58-1, 50 g
A local anesthetic; reduces electrically induced peak CAP amplitudes in isolated frog sciatic nerve (IC50 = 0.21 mM); topical administration inhibits winking in a rabbit corneal test, indicating anesthetic activity, at 0.35 and 0.6%; inhibits the pinprick-induced CTMR in the skin of rats (ED50 = 42.1 μmol, s.c.)
Cayman Chemical (E)-Anethol, Purity: ≥95%, CAS: 4180-23-8, 100 g
A phenylpropanoid with antifungal and antioxidant activity; active against fermentatively growing S. cerevisiae under hypoxic, but not normoxic, conditions (MIC = 100 µg/ml), and against C. parapsilosis at 15% w/w; has antioxidant activity in a TEAC assay but does not scavenge DPPH radicals in a cell-free assay
Cayman Chemical Trimebutine, Purity: ≥98%, CAS: 39133-31-8, 50 g
An opioid receptor agonist; It binds to μ-, δ-, and κ-opioid receptors (Kis = 0.34, 0.5, and 0.58 μM, respectively, in canine myenteric plexus synaptosomes) inhibits twitch contraction and ACh release induced by low-frequency electrical stimulation in isolated guinea pig LM-MP (EC50s = 0.274 and 0.215 μM, respectively); increases twitch contraction and ACh release induced by high-frequency electrical stimulation in isolated guinea pig LM-MP at ≤1 μM, but inhibits these effects at ≥10 μM; decreases the amplitude and frequency of spontaneous contractions in isolated guinea pig colonic smooth muscle strips at 30, 100, and 300 μM; inhibits BKCa and L-type calcium currents in colonic smooth muscle cells
Cayman Chemical 2-O-α-D-Glucopyranosyl-L-ascorbic Acid, Purity: ≥95%, CAS: 129499-78-1, 10 g
An L-ascorbic acid derivative with antioxidant and radioprotective activities; scavenges DPPH radicals in a cell-free assay (EC50 = 61 μM in 60% ethanol); inhibits γ-radiation-induced cell death in CHO-10B2 and radiosensitive xrs5 cells, as well as UVC- or broadband UVB-induced cell death in CHO-10B2 and UV-sensitive UV135 cells, at 5 mM; increases serum levels of ascorbic acid in rats and guinea pigs at 19.2 and 96 mg/animal, p.o., respectively; reverses weight loss and inhibits subcutaneous hemorrhage in guinea pigs fed a vitamin C-deficient diet at 19.2 mg/animal per day
Cayman Chemical Rifamycin SV (sodium salt hydrate), Purity: ≥98%, 500 mg
A broad-spectrum antibiotic that inhibits bacterial DNA-dependent RNA polymerase
Cayman Chemical L-Folinic Acid (calcium salt hydrate), Purity: ≥98%, 1 g
A reduced folic acid; isomer of DL-folinic acid
Cayman Chemical D,L-Buthionine-(S,R)-Sulfoximine, Purity: ≥95%, CAS: 5072-26-4, 5 g
A γ-glutamylcysteine synthetase inhibitor (100% inhibition at a concentration of 10 μM in an enzyme assay); selective for γ-glutamylcysteine synthetase, lacking activity at glutamine synthetase at concentrations up to 500 μM; reduces renal glutathione in mice without inducing abnormal behavior or convulsions at a dose of 32 mmol/kg; eliminates T. brucei from the bloodstream of infected mice via depletion of intratrypanosomal glutathione and induction of oxidative stress at a dose of 4 mmol/kg; an isomeric mixture of L-buthionine-S-sulfoxime, L-buthionine-R-sulfoxime, D-buthionine-S-sulfoxime, and D-buthionine-R-sulfoxime
Cayman Chemical Ethambutol (hydrochloride), Purity: ≥98%, CAS: 1070-11-7, 5 g
An antimycobacterial compound; inhibits the growth of M. tuberculosis in vitro at a concentration of 10 μg/ml; protective against M. smegmatis infections in rhesus monkeys (50, 30, and 0% fatalities at doses of 12.5, 25, and 50 mg/kg, respectively); clears M. smegmatis pulmonary infiltrates at a dose of 100 mg/kg
Cayman Chemical L-Arginine (hydrochloride), Purity: ≥98%, CAS: 1119-34-2, 25 g
An amino acid and precursor of NO; a substrate for NO synthase; enhances NO release in porcine aortic endothelial cells; induces vasodilation, increases blood flow, and reduces infarct size by 35 and 28% in normotensive and spontaneously hypertensive rats, respectively
Cayman Chemical D-Galactosamine (hydrochloride), Purity: ≥98%, CAS: 1772-03-8, 25 g
A hepatotoxic agent; an amino sugar derivative of galactose; used, alone or in combination with LPS, as a model of liver failure in rodents
Cayman Chemical Tetramethylrhodamine methyl ester (perchlorate), Purity: ≥98%, CAS: 115532-50-8, 50 mg
A cell-permeant fluorogenic dye used to assess mitochondrial function and cell viability; excitation/emission spectra 515 and 555/575 nm
Cayman Chemical Neostigmine (methyl sulfate), Purity: ≥98%, CAS: 51-60-5, 1 g
A reversible AChE inhibitor (Kd = 260 μM); dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 µg, respectively); restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block (5 μg, i.p.)
Cayman Chemical Nitrofurantoin, Purity: ≥98%, CAS: 67-20-9, 50 g
An antibiotic; reduces E. coli replication and abscess formation in the renal medulla of infected rats in a dose-dependent manner when administered at doses ranging from 25-100 mg/kg; prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates of P. mirabilis; prevents alkalization of urine as well as calculi and abscess formation in a rat model of P. vulgaris urinary tract infection
Cayman Chemical Oxybutynin (hydrochloride), Purity: ≥98%, CAS: 1508-65-2, 1 g
An antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively); inhibits carbachol- induced intracellular calcium mobilization in bladder smooth muscle and submandibular gland cells isolated from cynomolgus monkeys (Kis = 2 and 1 nM, respectively); inhibits VIBC and OIS in rats (ID50s = 0.062 and 0.089 mg/kg, respectively); increases PD and LMA (ED50s = 0.29 and 0.52 mg/kg, respectively) and decreases SIT (ID50 = 0.22 mg/kg) in rats