Goat Secondary Antibodies
Cayman Chemical Fludrocortisone Acetate, Purity: ≥98%, CAS: 514-36-3, 500 mg
A mineralocorticoid agonist; promotes sodium retention in rats in a dose-dependent manner with 37% of sodium excreted compared with control when used at a dose of 5 µg/animal
Cayman Chemical 17-phenyl trinor Prostaglandin F2α glycinamide methyl ester, Purity: ≥98%, 1 mg
A derivative of 17-phenyl trinor PGF2α ethyl amide
Cayman Chemical 5α,6α-epoxy Cholestanol, Purity: ≥95%, CAS: 1250-95-9, 250 mg
An oxysterol and an oxidative metabolite of cholesterol; accumulates in MCF-7 breast cancer cells following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to LXRβ; levels are increased in rat aorta and mesenteric artery following orchidectomy; levels are increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease
Cayman Chemical Decamethonium (bromide), Purity: ≥98%, CAS: 541-22-0, 10 g
A depolarizing neuromuscular blocking agent; a partial agonist of muscle-type nAChRs; activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes (EC50 = 40 µM); a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors (IC50s = 7.4, 405, 28, and 59 µM, respectively); a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 µM for the human receptor); inhibits electric eel AChE; blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 µg/kg for cats under chloralose and ether anesthesia, respectively
Cayman Chemical Carbinoxamine (maleate), Purity: ≥98%, CAS: 3505-38-2, 10 g
A histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine; competes with [3H]diltiazem for binding to the benzothiazepine site on rat cardiomyocytes (Ki = 1.08 nM); decreases negative inotropic activity in isolated guinea pig left atria by 76% (EC50 = 250 nM); decreases negative chronotropic activity in guinea pig spontaneously beating isolated right atria by 48%
Cayman Chemical Cacodylic Acid (sodium salt hydrate), Purity: ≥95%, CAS: 6131-99-3, 50 g
A reagent used in electron microscopy techniques; has been used to introduce arsenic into proteins for SAD phasing in protein crystallography; has been used as an herbicide/defoliant; increases the likelihood of tumor formation in rats exposed to carcinogens at concentrations as low as 50 ppm
Cayman Chemical Cortisone Acetate, Purity: ≥98%, CAS: 50-04-4, 25 g
A synthetic glucocorticoid with anti-inflammatory properties; decreases the size of BCG vaccine-induced dermal lesions and tuberculin reactions in rabbits (2 mg/kg on alternate days over the course of 46 days); slows tissue regeneration in a rabbit model of wound healing (2.5 mg/kg per day, s.c., over 4 weeks); decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%
Cayman Chemical Cortisone Acetate, Purity: ≥98%, CAS: 50-04-4, 5 g
A synthetic glucocorticoid with anti-inflammatory properties; decreases the size of BCG vaccine-induced dermal lesions and tuberculin reactions in rabbits (2 mg/kg on alternate days over the course of 46 days); slows tissue regeneration in a rabbit model of wound healing (2.5 mg/kg per day, s.c., over 4 weeks); decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%
Cayman Chemical Hydralazine (hydrochloride), Purity: ≥98%, CAS: 304-20-1, 10 g
An orally bioavailable vasodilator and antihypertensive agent; decreases DNA methylation in Jurkat cells at a concentration of 10 μM and inhibits extracellular and intracellular ROS production in PMA-activated rat macrophages at a concentration of 100 μM; (100 μM) also decreases nitric oxide production and mRNA expression of iNOS in LPS and IFN-γ-activated rat macrophages; reduces contraction of rat aortic arterial strips induced by potassium and norepinephrine (IC50s = 2.2 and 3.06 mM, respectively); lowers MAP by 41.76% in conscious rats (2.6 mg/kg)
Cayman Chemical Oxymetazoline (hydrochloride), Purity: ≥95%, CAS: 2315-02-8, 1 g
An agonist of α1- and α2-ARs (Kds = 6, 320, and 390 nM for α1A-, α1B-, and α1D-ARs, respectively, Ki = 15 nM for α2-AR); acts as an agonist of 5-HT1 receptors (Kds = 4.68, 25.7, 5.01 nM for 5-HT1A, 5-HT1B, and 5-HT1D, respectively); increases intracellular calcium levels in CHO cells transfected with the α1A-AR (EC50 = 40.7 nM); acts as a partial agonist of the α2-AR in perfused rat heart (IC50 = 63 nM and EC50 = 13.5 nM for norepinephrine release); acts as an agonist and antagonist of the 5-HT1C receptor in the presence of methiothepin and clonidine, respectively (Kds = 110 and 257 nM, respectively); inhibits forskolin-stimulated adenylate cyclase activity (EC50s = 18.6, 24.0, and 44.7 nM in tissues expressing high levels of 5-HT1A, 5-HT1B, and 5-HT1D receptors, respectively) and accumulation of inositol phosphates (EC50 = 269 nM in pig choroid plexus preparations, which highly express 5-HT1C receptors); decreases nasal pressure in dogs by 6.9% when used at a dose of 0.2 μg/kg
ABclonal Technology 488 anti-Human CD225/IFITM1
Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins The family contains five members including IFITM1 IFITM2 and IFITM3 that belong to the CD225 superfamily The protein encoded by this gene restricts cellular entry by diverse viral pathogens such as influenza A virus Ebola virus and Sars-CoV-2
Cayman Chemical Amylin (1-13) (human, mouse, rat), (trifluoroacetate salt), Purity: ≥95%, 1 mg
A peptide fragment of amylin
Cayman Chemical Thiamine (hydrochloride), Purity: ≥98%, CAS: 67-03-8, 50 g
A water-soluble vitamin with diverse biological activities; inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro from 1-100 μM; reduces hepatic levels of AST and ALT, lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication at 100 mg/kg; reverses predator stress-induced suppression of hippocampal neurogenesis and decreases latency of step-down from a platform in mice; reduces neurodegeneration and increases survival in Slc19a3-/- mice at 8.5 mg/100 g food
Cayman Chemical Dexchlorpheniramine (maleate), Purity: ≥98%, CAS: 2438-32-6, 1 g
A histamine H1 receptor antagonist (pA2 = 9.36 in guinea pig ileal tissue); inhibits specific allergen-challenged peripheral blood mononuclear cell proliferation by 92% in vitro (4.8 µM); reduces noradrenaline uptake in rat vas deferens ex vivo (10 µM); increases pain threshold in mice exposed to thermal and chemical stimulation (30 mg/kg, i.p.)
Cayman Chemical Secoisolariciresinol Diglucoside, Purity: ≥98%, CAS: 158932-33-3, 100 mg
A lignan with diverse biological activities; scavenges DPPH radicals (IC50 = 78.9 μg/ml) in a cell-free assay; dose-dependently inhibits the growth of SW480 human colon cancer cells; dietary administration reduces the number of proliferating tumor cells in an MCF-7 human breast cancer mouse xenograft model in the presence of circulating estrogen; increases insulin and decreases glucose serum levels in rats with streptozotocin-induced diabetes at 20 mg/kg; decreases infarct size in rats with myocardial infarction induced by permanent occlusion of the left anterior descending coronary artery at a 20 mg/kg per day