Custom Enzymes and Inhibitors
Epigentek Inc EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric) (96 assays)
For absorbance-based measurement of DNA methyltransferase activity or inhibition
Selleck Chemical LLC MLN8054 5mg 869363-13-3
MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM in Sf9 insect cell. It is more than 40-fold selective for Aurora A than Aurora B. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Temsirolimus (CCI-779) 10mg 162635-04-3 NSC 683864
Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 ?M in a cell-free assay. Temsirolimus induces autophagy and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Talazoparib (BMN 673) 10mg 1207456-01-6 LT-673
Talazoparib (BMN 673, LT-673) is a novel PARP inhibitor with IC50 of 0.57 nM for PARP1 in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Meridian Life Science Tru Block, 0.1 g
HAMA Blocker against Immunoassay Interference - actively blocks Heterophilic Antibody (HA) interference in immunoassays including, but not limited to, Human Anti-Mouse Antibody (HAMA) interference.
Chemie Tek PI3K INHIBITOR
BYL179 is an orally bioavailable, next generation PI3K alpha - isoform specific inhibitor, currently in clinical trials.
Enzo Life Sciences Ubiquitin aldehyde (recombinant) (50 µg)
High purity inhibitor of deubiquitinylating enzymes (DUBs). Synthetically modified recombinant ubiquitin. The modification of the C-terminal glycine carboxyl into an aldehyde results in a potent, highly specific inhibitor of all ubiquitin deconjugating enzymes, including ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs) and deubiquitinylating enzymes (DUBs). Alternative name: Ub-H. MW: 8.5kDa. Purity: ≥95% (HPLC). Sequence Recombinant Ubiquitin (corresponding to UniProt sequence P62988). The C-terminal glycine carboxyl is synthetically modified to an aldehyde. Formulation: Liquid. In aqueous solution containing 0.15M HCl. Source: Produced in E.coli. UniProt: P0CG47 (UBB), P0CG48 (UBC), P62979 (RPS27A), P62987 (UBA52). Handling: Do not neutralise until immediateley prior to use. Do not lyophilize. Avoid presence of amino-containing compounds. Soluble and stable in aqueous solution at pH <7.0. Long Term Storage: +4°C
Sigma Organic Chemistry trans-2-Phenylcyclopropyl isocyanate | 5G | 63009-74-5 | MFCD00001273
CAS #: 63009-74-5
MDL #: MFCD00001273
Purity: >90%
UNSPSC Code: 12352100
Molecular Weight: 159.18
Selleck Chemical LLC BI 2536 10mM/1mL 755038-02-9
BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC PD98059 10mM/1mL 167869-21-8
PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 ?M in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Raltitrexed 10mg 112887-68-0 ZD-1694
Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. *For Research & Development use only. Product is not intended for drug, household, or human consumption.