Custom Enzymes and Inhibitors
Medchemexpress LLC NAE-IN-M22 10mg | 864420-54-2 | 363.32 g·mol-1 | C20H24Cl2N2 | 10 MG
NAE-IN-M22 is a potent, selective, and reversible inhibitor of the NEDD8-activating enzyme (NAE) used as a research tool to study neddylation-dependent signaling and apoptosis in cancer cell models. Supplied as a high-purity small-molecule solid, it is intended for laboratory research use only.
- Inhibits NEDD8-activating enzyme in vitro and in vivo.
- High purity (99.94%).
- Supplied in mg-scale pack sizes, including 10 mg.
- Suitable for studies of neddylation, ubiquitin-like modification, and apoptosis.
- Store powder at -20°C for long-term stability; follow solvent storage recommendations for solutions.
Apexbio Technology LLC 1-NM-PP1, 221244-14-0, MFCD17010191, 10 mg
MF: C20H21N5, MW: 331.41, Solubility: 16.55mg/mL in DMSO, 9.22 mg/mL in EtOH with ultrasonic and warming,insoluble in H2O. 1-NM-PP1 is a C3-modified analog of cell-permeable PP1, acts as a potent and selective inhibitor of protein kinase families.
Enzo Life Sciences RO-3306, (1mg), CAS Number: 872573-93-8
CDK/cyclin inhibitor. Inhibitor of CDK1/cyclin B1 and CDK1/cyclin A. Reversibly arrests human cells at the G2/M border of the cell cycle. Allows for effective cell synchronisation in early mitosis. Downregulates expression of the antiapoptotic proteins Bcl-2 and survivin and blocks p53-mediated induction of p21 and MDM2. Alternative Name: (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one. Formula: C18H13N3OS2. MW: 351.4. CAS Number: 872573-93-8. Purity: ≥95% (HPLC). Appearance: Brown solid. Solubility: Soluble in DMSO (5mg/ml). Use/Stability: Stable for at least 6 months after receipt when stored at -20°C in the dark. Long Term Storage: -20°C
Medchemexpress LLC Ly294002 Hcl 1Mm 10Ml Solid | HY-10108A-10MM-1MLSOLID
Ly294002 Hcl 1Mm 10Ml Solid
Sigma Aldrich Fine Chemicals Biosciences Sumatriptan succinate United States Pharmacopeia (USP) Reference Standard | 103628-48-4 | MFCD00902856 | 200MG
Sumatriptan succinate United States Pharmacopeia (USP) Reference Standard | Mol Wt: 413.49 | 103628-48-4 | MFCD00902856 | 200MG
Ace Glass, Inc. 250mL GL32 top #50 bottom peptide vessel body, 2mm bore PTFE stopcock side port
250ML GL32 NO.50 PEPT BODY
New England Biolabs, Inc. Uracil Glycosylase Inhibitor (UGI) – 200 units
The Uracil Glycosylase Inhibitor (UGI) of Bacillus subtilis bacteriophage PBS1 is a small protein (9.5 kDa) which inhibits E. coli uracil-DNA glycosylase (UDG) as well as UDG from other species. Inhibition of UDG occurs by reversible protein binding with a 1:1 UGD:UGI stoichiometry. UGI is capable of dissociating UDG-DNA complexes.
Apexbio Technology LLC KU-60019 925701-49-1 10mg
KU-60019 is a selective inhibitor targeting ataxia telangiectasia mutated (ATM) kinase with an IC50 value of approximately 6 3 nM Through inhibition of ATM kinase activity KU-60019 influences cellular DNA damage responses and sensitivity to radiation therapy It has been demonstrated to enhance radiosensitivity in human fibroblast cells expressing functional ATM but not in ATM-deficient cells Additionally KU-60019 reduces radiation-induced phosphorylation of AKT at Ser473 in glioma cell lines independently affecting cell migration invasion and proliferation KU-60019 serves as an investigational tool for exploring ATM-dependent signaling pathways and examining therapeutic strategies against cancers involving ATM-regulated DNA repair and cell survival mechanisms
Selleck Chemical LLC MLN8054 5mg 869363-13-3
MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM in Sf9 insect cell. It is more than 40-fold selective for Aurora A than Aurora B. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Reprocell STEMOLECULE CHIR99021 (10MG)
Size 2 mg (Cat. No. 04-0004) 10 mg (Cat. No. 04-0004-10) Alternate Name 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2 pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile Chemical Formula C22H18Cl2N8 Molecular Weight 465.34 CAS Number 252917-06-9 Purity Greater than 95% by HPLC analysis Formulation Off-white solid Solubility Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet. Storage and Stability Store powder at 4°C protected from light. Following reconstitution, store aliquots at -20°C. Stock solutions are stable for 6 months when stored as directed. Quality Control The purity of CHIR99021 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of CHIR99021 was tested on mouse embryonic stem cells.
Sigma Aldrich Fine Chemicals Biosciences 4-Quinolinol 98% | 611-36-9 | MFCD00006777 | 10G
4-Quinolinol 98% | Purity: 98% | Mol Wt: 145.16 | 611-36-9 | MFCD00006777 | 10G
Selleck Chemical LLC Nutlin-3 25mg 890090-75-2
Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC JNJ-38877605 5mg 943540-75-8
JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Aprepitant 5mg 170729-80-3 MK-0869, L-754030
Aprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNF?. Aprepitant inhibits HIV infection of human macrophages. *For Research & Development use only. Product is not intended for drug, household, or human consumption.