Custom Peptides
Cayman Chemical N6-CyclopentyladenosIn 10mg
A selective agonist at A1R (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively)
Cayman Chemical CholSTRyl EIcosaPNtaenoat 10mg
A cholesterol ester; induces cytotoxicity in human monocyte-macrophages at 88-880 μM; levels are elevated 1.89-fold in the serum of pediatric patients with extrahepatic biliary atresia and decreased in the serum and plasma of patients with Alzheimer’s disease and abetalipoproteinemia, respectively, compared with healthy individuals
Cayman Chemical NCGC00244536 10mg
A KDM4B/JMJD2B inhibitor (IC50 = ~10 nM); selective for KDM4B/JMJD2B over KDM5A/JARID1 and LSD1 but does inhibit KDM4A/JMJD2A, KDM4C/JMJD2C, and KDM4D/JMJD2D at 10 μM; inhibits the growth of various prostate cancer cells (IC50s = <1 μM for all); reduces androgen receptor levels and H3K9 trimethylation in isolated human solid prostate tumors; reduces tumor volume in a PC3 mouse xenograft model at 20 mg/kg
Cayman Chemical 1-DeoxysphngnInm18 0 10mg
An atypical sphingolipid; plasma levels of 1-deoxysphinganine are increased in patients with HSAN1 and GSDI; not converted to canonical sphingolipids or fatty acids and accumulates in mitochondria, inducing mitochondrial fragmentation and dysfunction; accumulates in LLC-PK1 cells and in mouse liver and kidney following application or administration, respectively, of fumonison B1; neurotoxic to dorsal root ganglion neurons in vitro at 1 µM; cytotoxic to DU145 cells (IC50 = ~2 µM) but stimulates DNA synthesis in Swiss 3T3 cells at 1 µM
Cayman Chemical NLG-919 nalog 10mg
An inhibitor of IDO1 and TDO (IC50s = 79 and 25 nM, respectively, in cell-free assays); decreases kynurenine levels in cells expressing human IDO1 (EC50 = 83 nM); decreases the percentage of PD-1+ anti-CD3- and anti-CD28-activated Jurkat T cells from 0.025-1 µM; decreases tumor volume and weight and the percentage of intratumoral CD4+CD25+ Tregs in a B16/F10 murine melanoma model at 100 mg/kg when administered alone or in combination with paclitaxel
Cayman Chemical nastrozole 10mg
An aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1); selective for aromatase/CYP19A1 over CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM); blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats at 0.1 mg/kg; inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys at ≥0.1 mg/kg; reduces tumor incidence and the number of tumors well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis at 0.5 mg/kg
Cayman Chemical S-AdenosylhomocysteIn 10mg
An amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis; also a product of SAM-dependent methylation of biological molecules, including DNA, RNA, and histones, and other proteins
Cayman Chemical OlopatdInhydrochlorIde 10mg
A histamine H1 receptor antagonist (Ki =41 nM); 1,059- and 4,177-fold selective for histamine H1 over H2 and H3 receptors, respectively; inhibits histamine-induced phosphoinositide turnover in isolated human conjunctival epithelial cells, isolated human corneal fibroblasts, and human TM3 cells (IC50s = 9.5, 19, and 39.9 nM, respectively); inhibits passive cutaneous anaphylaxis in rats (ED50 = 49 UG/kg) and IgG1-mediated bronchoconstriction in ovalbumin-sensitized guinea pigs (ED50 = 30 UG/kg)
Cayman Chemical 5-methoxy MIPT 10mg
A psychedelic tryptamine which potently inhibits the re-uptake of the monoamines serotonin and norepinephrine (IC50s = 6.4 and 2.6 μM, respectively), but does not affect dopamine re-uptake; intended for forensic and research applications
Cayman Chemical FexofenadInhydrochlorIde 10mg
A histamine H1 receptor antagonist (Ki = 10 nM); reverses acetyl-β-methylcholine-induced contraction of isolated rat tracheal strips; inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells; reduces severity of colitis and phospho-IκB kinase activation in a mouse model of DSS-induced colitis
Cayman Chemical 3-p-FBThydrochlorIde 10mg
A tropane alkaloid whose physiological and toxicological properties are not known
Cayman Chemical CryptotnshInon 10mg
A natural quinoid diterpene that, at 10-20 µM, stimulates AMPK in C2C12 myotubes and activates p38 MAPK in DU145 cells; inhibits SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells; has a variety of anti-cancer actions
Cayman Chemical BetaIn AldehydechlorIde 10mg
The physiological intermediate in the oxidation of choline to betaine
Cayman Chemical 2 3 5trIacetyl5AzacytId 10mg
A prodrug form of 5-azacytidine; decreases promoter methylation of P15 in L1210 mouse leukemia cells at 1 and 100 µM; reduces HIV-1 infection in, and increases the viability of, unstimulated primary human CD4+ T cells at 10 µM; decreases gut and spleen global DNA methylation levels in mice at 38 mg/kg per day for 5 consecutive days
Cayman Chemical SB-224289hydrochlorIde 10mg
A potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors