Custom Peptides
Cayman Chemical TelocInobufagIn 10mg
A cardiotonic steroid with diverse biological activities; inhibits human kidney Na+/K+-ATPase (IC50 = 44.2 nM); increases contraction force in isolated frog ventricle strips by 30.2% at 9.9 μg/ml; cytotoxic to HL-60, HCT8, SF295, MDA-MB-435 cancer cells, and human peripheral blood lymphocytes (IC50s = 0.06, 0.06, 0.03, 0.11, and 0.05 μM, respectively); active against E. coli and S. aureus (MICs = 64 and 128 μg/ml, respectively)
Cayman Chemical EchInacosIde 10mg
A phenylethanoid glycoside; scavenges DPPH radicals (EC50 = 6.6 µM in a cell-free assay); inhibits hydrogen peroxide-induced production of ROS in a cell-free assay at 10 UG/ml; reduces increases in plasma ALT, TNF-α, IL-1β, IL-16, and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury at 60 mg/kg; prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and DOPAC levels in a mouse model of MPTP-induced Parkinson's disease; improves motor performance in the rotarod test in the same model
Cayman Chemical CholSTRyl DocosaPNtaenoat 10mg
A cholesterol ester; elevated in liver, plasma, and skeletal muscle of ACBP knockout mice
Cayman Chemical 7 8-dIhydro-L-BIopterIn 10mg
BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 µM.{1268}
Cayman Chemical QuIzartInIb 10mg
A selective FLT3 inhibitor (Kd = 1.6 nM) that inhibits the proliferation of MV4-11 cells both in vitro (IC50 = 0.56 nM) and in in vivo mouse models of FLT3-ITD acute myeloid leukemia
Cayman Chemical 1 2DIoleoylsnglycero3PG 10mg
A phospholipid containing the long-chain (18:1) fatty acid oleic acid inserted at the sn-1 and sn-2 positions
Cayman Chemical on-AE3-208sodIum salt 10mg
An antagonist of the EP4 receptor (Ki = 1.3 nM) that less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors; implicates EP4 signaling in immune and autoimmune responses, inflammation, and cancer
Cayman Chemical HomovnIlIc AcId sulfateso 10mg
A phenol found in olive oil and a dopamine metabolite; a component of LDL in humans that consume olive oil; levels are increased in response to acute renal injury in humans and rats; has been used as a biomarker for EArly detection of kidney disease in pediatric nephrology
Cayman Chemical GalactosylsphngosInd18 1 10mg
A bioactive sphingolipid; potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes; induces demyelination of mouse cerebellar slices at 0.1 and 1 µM; inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes; inhibits PPARα-mediated gene transcription in C6 glial cells at 10 and 15 µM; levels are increased in postmortem brain from patients with Krabbe disease
Cayman Chemical 8- 3-ChlorostyrylcaffeIn 10mg
An adenosine A2 receptor antagonist (Ki = 54 nM); selective for adenosine A2 over A1 receptors (Ki = 28 µM); reverses APEC-induced locomotor depression in mice (ED50 = 16 UG/kg, i.p.); increases locomotion in mice at 5 mg/kg; reverses L-DOPA-induced shortening of the rotational motor response and increases in striatal adenosine A2 receptor levels in a rat model of 6-OHDA-induced Parkinson's disease at 5 mg/kg; inhibits MAO-B (Ki = 100 nM); reduces MAO-B activity in brain mitochondrial preparations from wild-type and A2A-/- mice
Cayman Chemical Dynole 34-2 10mg
A dynamin inhibitor (IC50s = 6.9 and 14.2 µM for dynamin 1 and dynamin 2 GTPase activity, respectively); induces multinucleation, inhibits cytokinesis, and induces apoptosis in HeLa cells at 10 µM; inhibits proliferation of several cancer cell lines (GI50s = 5.8-15 µM)
Cayman Chemical Buca ntdysntca Bucntn 10mg
A quassinoid with diverse biological activities; inhibits protein synthesis in HeLa cells, reticulocytes, and reticulocyte lysates (IC50s = 30, 40, and 1,600 nM, respectively); active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 8 and 13 nM, respectively); induces apoptosis in HL-60 leukemia and RPMI-8226 multiple myeloma cells (IC50s = 12.2 and 12.8 nM, respectively); induces tumor regression in an RPMI-8226 mouse xenograft model at 5 mg/kg
Cayman Chemical RutaecarpIn 10mg
A quinazolinone alkaloid with diverse biological activities; inhibits COX-1 and COX-2 in BMMC cells (IC50s = 8.7 and 0.28 µM, respectively); selective for COX-2 in HEK293 cells (IC50s = >400 and 2.8 µM, for COX-1 and COX-2, respectively); slows cancer cell growth in vitro (GI50s = 8.41-31.6 µM); induces vasodilation (0.1-10 µM) in isolated rat aorta; decreases plasma levels of caffeine in rat through CYP1A2 and CYP2E1 metabolism induction at a dose of 80 mg/kg
Cayman Chemical ntagonIst GtrIfluoroACTAt 10mg
A neuropeptide antagonist; inhibits binding of vasopressin to rat liver or Swiss 3T3 membranes (IC50s = 3.5 and 2.2 µM, respectively); inhibits vasopressin-induced production of inositol phosphate in Swiss 3T3 fibroblasts (IC50 = 1 µM); induces apoptosis and the production of ROS in NCI H69 cells at 50 µM; reduces tumor growth in an NCI H69 mouse xenograft model at 45 UG/g