Custom Peptides
Cayman Chemical NourseothrIcInsulfate 10mg
A broad-spectrum antibiotic that inhibits protein synthesis by inducing miscoding; commonly used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa, plants, and mammalian cells
Cayman Chemical 6mthylsulfInylheyl IsoTHO 10mg
An isothiocyanate with diverse biological activities; inhibits NO production in mouse peritoneal exudate macrophages at 5 µM; inhibits arachidonic acid-induced aggregation of isolated human platelets (IC50 = 21.9 µM); reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM); reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of 6-OHDA-induced Parkinson's disease at 5 mg/kg twice weekly; reduces the number of lung metastases in a B16/F10 murine melanoma model
Cayman Chemical 5a-ndrost-16-en-3a-ol 10mg
A pheromone with diverse biological activities; enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 = 0.4 µM); increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2 and α2β2γ2 subunit-containing GABAA receptors from 0.1-1 µM; has antidepressant-like effects in mice from 5-10 mg/kg; has anxiolytic-like effects in mice from 30-50 mg/kg; protects against PTZ- or electroshock-induced seizures in mice (ED50s = 48.9 and 21.9 mg/kg, respectively)
Cayman Chemical CInamtnIn B-1 10mg
A polyphenol antioxidant; inhibits lipid peroxidation in vitro (IC50 = 2.25 µM); improves wound healing in mice; COX-2 inhibitor with 19, 27, and 86% inhibition in Sf9 cells at 10, 100, and 1,000 UG/ml, respectively
Cayman Chemical Tafenoqun 10mg
An antimalarial agent; active against multidrug-resistant clinical isolates of P. falciparum (IC50s = 64.6-110.4 ng/ml); inhibits sporozoite transmission to mosquitos fed on P. berghei-infected mice at 25 or 50 mg/kg; suppresses parasitemia in a hamster model of B. microti infection from 3.25-52 mg/kg
Cayman Chemical ChelerythrInchlorIde 10mg
A potent, cell permeable inhibitor of PKC (IC50 = 660 nM); also inhibits Bcl-xL function (IC50 = 1.5 μM), inducing apoptosis in several cancer cell lines; can have PKC-independent effects, activate p38 and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo
Cayman Chemical 3 3 5-TrIIodo-L-thyronIn 10mg
A thyroid hormone that is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than T3; activates TRΔα1, a native form of TRα that lacks a nuclear localization signal and functions in the cytoplasm, initiating actin polymerization
Cayman Chemical 5-IAIhydrochlorIde 10mg
A psychoactive analog of p-iodoamphetamine that is indistinguishable, in its physiological effects, from MDMA in rats; significantly reduces both serotonin uptake sites and hippocampal serotonin levels in rats; intended for forensic applications
Cayman Chemical EpIrubIcInhydrochlorIde 10mg
A stereoisomer of the antitumor anthracycline doxorubicin that undergoes β-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin; equally cytotoxic to HeLa cells compared to doxorubicin (ID50s = 9 μM)
Cayman Chemical Cysmethynil 10MG
An indole-based, time-dependent inhibitor of Icmt (IC50 = i = 0.14 µM for the final complex); decreases mTOR signaling, accumulation of cells in the G1 phase, and autophagy-mediated cell death in PC3 prostate cancer cells
Cayman Chemical BIA 10-2474 10mg
An inhibitor of FAAH (IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme); inhibits FAAH2, ABHD6, CES2, and PNPLA6 (IC50s = 0.4, 0.081, 2, and 11 μM, respectively); alters expression of 161 lipid species, including FAAH substrates as well as other lipid classes, in human cortical neuron cultures indicating compound promiscuity
Cayman Chemical NoctadecnoylLHomoserIn l 10mg
One of four lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum sensing signaling in strains of S. meliloti, a nitrogen-fixing bacterial symbiont of the legume M. sativa
Cayman Chemical Sulfonadyn-47 10mg
A dynamin inhibitor; inhibits dynamin GTPase activity in a cell-free assay (IC50 = 3.5 µM); inhibits clathrin-mediated endocytosis in U2OS cells (IC50 = 27.3 µM), as well depolarization-stimulated uptake of FM4-64 in isolated rat brain synaptosomes (IC50 = 12.3 µM); has anticonvulsant activity in the 6 Hz corneal kindling mouse model of seizures at 30 and 60 mg/kg
Cayman Chemical 17phenyl trInor Prostglnd 10mg
17-phenyl trinor PGD2 is a novel, chemically stable analog of PGD2 wherein the lower side chain is modified by the addition of a phenyl group at C-17 in place of the last 3 ω-chain carbon atoms. This modification has not been reported in a D-type prostaglandin. However, in the PGE and PGF series, the analogous modification leads to a stable, somewhat more potent agonist which embodies the same biological activities as the parent prostaglandins.