Custom Peptides
Cayman Chemical IsobutyrylLcarnItInchLR 10mg
An acylcarnitine; elevated levels are associated with isobutyryl-CoA dehydrogenase deficiency
Cayman Chemical AcVDVADAFCtrIfluoroACTAt 10mg
A fluorogenic substrate for caspase-2; AFC is released upon enzymatic cleavage by caspase-2 and its fluorescence can be used to quantify caspase-2 activity; ex/em = 400/505 nm, respectively
Cayman Chemical FebrIfugInhydrochlorIde 10mg
A quinazolinone with antimalarial activity; reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 at 1 mg/kg per day
Cayman Chemical IpronIdazole 10mg
A nitroimidazole antiprotozoal agent; dietary administration reduces H. meleagridis-induced mortality in young turkeys from 0.00312-0.0094% w/w; induces 100% disease clearance in bulls infected with T. foetus at 60 g/animal
Cayman Chemical ChIkusetsusaponIn IVa 10mg
An oleanane-type triterpenoid with diverse biological activities; inhibits the growth of HL-60 and HCT116 cells (IC50s = 76.23 and 78.11 µM, respectively); reduces LPS-induced increases in iNOS, COX-2, IL-1β, IL-6, and TNF-α levels in PMA-differentiated THP-1 macrophages at 50-200 UG/ml; decreases plasma glucose, triglyceride, and LDL-cholesterol, and increases HDL-cholesterol, levels in a rat model of STZ- and high-fat diet-induced type 2 diabetes at 45-180 mg/kg
Cayman Chemical TrofIntIdeacetate 10mg
A derivative of Gly-Pro-Glu; decreases okadaic acid-induced cell death in primary rat embryonic striatal neurons at 10 nM; reduces brain expression of mRNA encoding IL-1β, TNF-α, IL-6, and E-selectin in a penetrating ballistic-like brain injury-induced rat model of neuroinflammation; reduces cortical and striatal infarct area in a MCAO-induced rat model of brain injury at 30 and 60 mg/kg; reduces the number of dendritic spines and reverses deficits in social recognition and contextual fear conditioning, as well as decreases testicular weight gain, in an fmr1-/- knockout mouse model of fragile X syndrome at 100 mg/kg per day
Cayman Chemical PRfluorohexnsulfonIc AcId 10mg
A perfluoroalkyl substance; activates PPARα in a reporter assay using COS-1 cells expressing the human or mouse receptor from 5-100 µM; has been found in landfill leachate and sea and river water
Cayman Chemical RTDLdLRTYTLtrIfluoroACTAt 10mg
An αVβ6 integrin ligand; selectively inhibits the binding of fibronectin to αVβ6 integrin over vitronectin to αVβ3 or αVβ5 and fibrinogen to αIIβ3 (IC50s = 0.02, >50, >50, and >50 µM, respectively); inhibits the binding of HT-29 colon cancer cells to fibronectin
Cayman Chemical CInamoylglycIn 10mg
A metabolite of trans-cinnamic acid; urinary levels are decreased in a mouse model of piperacillin- and tazobactam-induced gut microbiota colonization resistance; serum levels are increased in patients with CKD
Cayman Chemical SynthetIc HIspolon 10mg
A phenol with diverse biological activities; scavenges superoxide and hydroxyl radicals in cell-free assays, as well as reduces LPS-induced production of ROS in RAW 264.7 cells at 5 and 10 µM; inhibits cell proliferation and induces apoptosis in C6 rat glioma and DBTRG-05MG human glioblastoma cells from 60-80 µM; reduces acetic acid-induced writhing in mice at 20 mg/kg
Cayman Chemical EstropIpate 10mg
A piperazine salt form of estrone 3-sulfate; inhibits OATP1B1 selectively over OATP1B3 (IC50s = 0.06 and 19.32 µM, respectively)
Cayman Chemical Sulfonadyn-47 10mg
A dynamin inhibitor; inhibits dynamin GTPase activity in a cell-free assay (IC50 = 3.5 µM); inhibits clathrin-mediated endocytosis in U2OS cells (IC50 = 27.3 µM), as well depolarization-stimulated uptake of FM4-64 in isolated rat brain synaptosomes (IC50 = 12.3 µM); has anticonvulsant activity in the 6 Hz corneal kindling mouse model of seizures at 30 and 60 mg/kg
Cayman Chemical N6 6AmInohexylcarbamoylme 10mg
An alkylated ADP derivative; has been biotinylated and conjugated to an azidonitrobenzoyl group for use as a photoaffinity probe to visualize the ATPase site of rabbit myosin