Custom Peptides
Cayman Chemical DexloxIglumIde 10mg
A CCK1 receptor antagonist; selectively binds to the CCK1 receptor over CCK2 in CHO cells expressing the rat receptors (Kis = 0.0234 and 5.88 µM, respectively); inhibits guinea pig CCK-8S-induced gall bladder contractions at 20 µmol/kg; reduces CCK-8-induced gastric emptying in rats (ID50 = 1.14 mg/kg)
Cayman Chemical 7 4-DI-O-methylapIgenIn 10mg
A flavonoid with diverse biological activities; inhibits MAO-B but not MAO-A (IC50s = 0.198 and >100 µM, respectively), as well as p38α MAPK but not JNK3 (IC50s = 27.8 and >100 µM, respectively); inhibits NO production in LPS-stimulated RAW 264.7 macrophages (IC50 = 24.5 µM); reduces the growth of C. albicans at 45 UG/ml; inhibits carrageenan-induced edema in rats (ED25 = 75 mg/kg)
Cayman Chemical HydroxymetronIdazole 10mg
An active metabolite of metronidazole; active against B. fragilis, B. thetaiotaomicron, B. distasonis, and B. ovatus (MICs = 1, 2, 1, and 2 UG/ml, respectively); has been found in pork and porcine plasma
Cayman Chemical Isoflupredon 10mg
A glucocorticoid and mineralocorticoid receptor agonist (EC50s = 0.877 and 0.007 nM, respectively, in transactivation assays); inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 = 25.5 nM); topical application of an isoflupredone-containing solution inhibits croton oil-induced EAr edema in rats (ED50 = 51.9 nM); increases MAP and decreases the levels of potassium and sodium in the plasma and urine, respectively, in sheep at 0.6 mg/day; reduces tumor levels of uridine incorporation into 18S and 28S rRNA in a P1798 murine lymphoma model at 25 mg/kg
Cayman Chemical GusacItInIb 10mg
A dual inhibitor of JAKs (IC50s = 46, 4, and 11 nM for JAK1-3, respectively) and Syk family kinases (IC50s = 5 and 8 nM for SyK and TYK2, respectively)
Cayman Chemical Salva japonca Salvgen 10mg
A polyphenol flavonoid with diverse biological activities; inhibits hydrogen peroxide-induced apoptosis and reduces the generation of ROS in SH-SY5Y cells at 25 µM; decreases cleaved caspase-3 levels and the Bax/Bcl-2 ratio in SH-SY5Y cells at 25 and 50 µM; reduces the viability of MCF-7 human breast cancer cells; enhances the DTH response to sheep red blood cells in mice at 3.65-9.68 UG/mouse per day; increases lysate antigen-induced production of IFN-γ in isolated mouse splenocytes; reduces tumor growth in a SMMT model at 9.68 UG/mouse per day
Cayman Chemical DelafloxacIn 10mg
A fluoroquinolone antibiotic that demonstrates extremely high potency against a wide range of bacteria in vitro; has an anionic structure, which enhances its potency in acidic environments and in skin and soft tissue infections
Cayman Chemical -Glu-AlatrIfluoroACTAte100mg
A dipeptide; has been found in P. roqueforti; has been found in ripened Gouda, goat, and Milner cheeses; a positive allosteric modulator of CaSR (EC50 = 4.8 µM in CaSR-expressing HEK293 cells); induces glutathionuria in mice at 4 mmol/kg; plasma levels are increased in malnourished neonatal mice; increased serum levels are positively associated with an increased risk of chronic kidney disease
Cayman Chemical NMethyl4pyrIdon5carboxa 10mg
A metabolite of nicotinic acid and a uremic toxin; plasma levels are increased and positively correlated with serum levels of MDA in patients with CKD
Cayman Chemical SardomozIdehydrochlorIde 10mg
An inhibitor of SAMDC (IC50 = 0.005 µM for the rat liver enzyme); selective for SAMDC over DAO (IC50 = 18 µM for the rat small intestine enzyme); inhibits proliferation of T24 cells (IC50 = 0.71 µM); decreases intracellular levels of spermidine and spermine and increases intracellular putrescine levels in L1210 cells at 3 µM; inhibits HIV-1 replication in PM1 cells at 0.2 and 0.4 µM; reduces tumor growth in a SK-MEL-24 melanoma mouse xenograft model at 0.5 and 5 mg/kg
Cayman Chemical Adnopoa tapyla Lupnon 10mg
A triterpenoid; inhibits HIV-1 reverse transcriptase (IC50 = 2.1 μM); active against the W2 and D6 strains of P. falciparum (IC50s = 208.1 and 394.7 ng/ml, respectively); induces melanogenesis in (EC50 = 0.35 µM), and inhibits the growth of, B16 2F2 cells in vitro (IC50 = 25.4 µM); topical application reduces TPA-induced EAr edema in mice at 1 mg/ear; inhibits acetic acid-induced writhing in mice at 100 mg/kg
Cayman Chemical Ala17-MCHtrIfluoroacetate 10mg
An MCH-derived peptide and MCH receptor agonist; binds to MCH1 and MCH2 receptors in CHO cells expressing the human receptors (IC50s = 0.15 and 3.5 nM, respectively); induces calcium mobilization in HEK293 cells expressing the human receptors (EC50s = 17 and 54 nM, respectively)
Cayman Chemical ChloraznIlhydrochlorIde 10mg
An analytical reference standard categorized as a diuretic; has been found as a potential doping agent in urine samples from athletes but can be formed from proguanil; intended for research and forensic applications
Cayman Chemical Lnsoprazole sulfon NoxIde 10mg
A potential impurity found in commercial preparations of lansoprazole