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A racemic mixture of 8(R)-KAPA and 8(S)-KAPA; biosynthesized as the 8(S) form but racemizes in culture media in a pH-dependent manner, with a higher racemization rate under very low (pH E. coli and M. tuberculosis DAPA AT, which leads to accumulation of 8(R)-KAPA in M. tuberculosis cultures after exogenous application of racemic KAPA
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An inhibitor of GLS1 (IC50 = 1 nM); selective for GLS1 over GDH (IC50 = >13 µM); inhibits the proliferation of A549, H22, Caki-1, and HCT116 cancer cells (IC50s = 0.017, 6.78, 0.019, and 0.009 µM, respectively); induces ROS production in A549 cells at 10 µM; decreases tumor weight in an HCT116 mouse xenograft model at 10 mg/kg
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A peptide; increases jejunum and ileum crypt depth and villus height without disrupting gut microbiota diversity in rats at 0.9 mg/kg four days per week; decreases lapatinib-induced diarrhea severity and incidence in rats; prevents lapatinib-induced loss of body weight in rats
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A hydroxy fatty acid methyl ester; major fatty acid component of A. lipolytica and A. glycerini; has been used in the synthesis of components of the female sex pheromone of the painted apple moth (T. anartoides)
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An orally bioavailable, non-selective calcium channel blocker; blocks L- and T-type calcium channels in GH3 rat pituitary cancer cells (IC50s = 0.5 and 1.5 μg/ml, respectively); blocks carbachol- and A23187-stimulated calcium influx in CHO cells expressing human recombinant M5 receptors (IC50s = 935 and 359 nM, respectively); inhibits the growth of T. gondii in non-cancerous human fibroblasts and HeLa human cervical cancer cells (IC50 = 0.06 μg/ml for both); inhibits the growth of human FaDu and EVSCC17M squamous cell carcinoma cells (IC50s = 13 and 15 μM, respectively) and of HUVECs (IC50 = 1 μM); inhibits angiogenesis in a chicken chorioallantoic membrane assay in vivo at 20 μM
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An analytical reference standard categorized as an SERM; has been detected as an AAF during anti-doping testing; intended for use in analytical forensic applications
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IRAK4 Recombinant Antibody (clone SAA1623) is a recombinant Mouse IgG2a, kappa antibody specific for IRAK4. It reacts with Human. Suitable for ELISA. Recombinant production ensures high specificity and lot-to-lot reproducibility. Supplied as 100 ug.
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An active metabolite of levofloxacin; active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 4, 1, 1, 0.012, >4, and 0.25 μg/ml, respectively)
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An α2-AR antagonist (Kis = 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively); reverses decreases in systolic blood pressure induced by clonidine in spontaneously hypertensive rats at 10 mg/kg
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A flavonoid with diverse biological activities; inhibits Kv1.3-mediated currents, induces membrane depolarization, and reduces calcium influx in Jurkat T cells; inhibits phytohemagglutinin-induced IL-2 release in Jurkat T cells; reduces type I collagen and fibronectin protein levels in TGF-β1-stimulated fibroblasts as well as contraction of TGF-β1-stimulated fibroblasts in a gel contraction assay at 25 μg/ml; reduces type I collagen and fibronectin protein levels and inhibits phosphorylation of ERK and JNK in isolated human hypertrophic scar tissue; increases glucose absorption and intracellular ATP levels in Ins-1 cells
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