Custom Peptides
Cayman Chemical ProcynIdIn A2 10mg
A flavanol dimer with diverse biological properties; scavenges DPPH radicals (IC50 = 5.08 μM); inhibits PDGF-induced STAT3 activation in primary rat VSMCs at 30 μg/ml; inhibits growth of S. aureus and E. coli (MICs = 62.5 and 62.5 μg/ml, respectively) and proliferation of human HepG2 liver hepatocellular carcinoma and HeLa cervical cancer cells (EC50s = 62.19 and 66.07 μg/ml, respectively); increases insulin secretion from primary mouse pancreatic islets at 10 μM; inhibits bisphenol A-induced glucose increases in fasted mice at 10 μmol/kg per day
Cayman Chemical Senosde B 10mg
A glycoside; inhibits H+/K+-ATPase activity in isolated rat stomach mucosa and increases levels of PGE2 in AGS gastric cells at 100 µM; increases the intestinal transport rate by 72.2% but has no effect on the gastric emptying rate in mice at 100 mg/kg; reduces lesion indices by 39.9 and 62.9% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcers, respectively, in rats at 100 mg/kg
Cayman Chemical Maytnsnol 10mg
An ansa macrolide; inhibits polymerization and induces depolymerization of bovine brain tubulin (EC50s = 12 and 43 µM, respectively); inhibits sea urchin egg mitosis at 10 µM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 UG/ml)
Cayman Chemical Ophopogons radx Ruscogen 10mg
A steroid sapogenin with diverse biological activities; reduces PMA-induced adhesion of HL-60 cells to ECV304 cells (IC50 = 7.76 nM); decreases zymosan A-induced peritoneal leukocyte migration in rats at 5 mg/kg; inhibits ADP-induced platelet aggregation in rats at 12.5 mg/kg; prevents monocrotaline-induced increases in MAP, expression of IL-1β and TNF in plasma and lung, and endothelial cell apoptosis in pulmonary arterioles in a rat model of pulmonary hypertension; reduces proteinuria and renal macrophage infiltration in a rat model of streptozotocin-induced diabetes; decreases gene expression of inflammatory cytokines, dyslipidemia, and liver steatosis in a hamster model of high-fat diet-induced NASH
Cayman Chemical Maltotetraose 10mg
A tetrasaccharide; increases the α-amylase synthesis rate in B. stearothermophilus three-fold greater than sucrose or glucose when used at at 0.1 mM; inhibits the growth of E. carotovora in a cylinder-agar plate assay at 750 μg/ml; inhibits TNF-α-induced expression of ICAM-1 in MOVAS-1 mouse VSMCs
Cayman Chemical 1PalmItoyl2hydroxysnglyc 10mg
A lysophospholipid; inhibits the growth of L. donovani promastigotes (GIC50 = 8 µM); serum levels are decreased in a mouse model of alcohol-induced liver injury and in a hepatocellular carcinoma mouse xenograft model; human serum levels are decreased immediately and 14 hours following an exercise regimen of 2.5 hours of running for three days; has been used as an internal standard for the quantification of saturated lysophosphoethanolamines
Cayman Chemical N-DesmethylclozapIn 10mg
An active metabolite of clozapine; originally described as an antagonist of 5-HT2C receptors (IC50 = 7.1 nM in rat choroid plexus); and later as an inverse agonist using human recombinant receptors; an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors; decreases exploratory locomotor activity and increases prepulse inhibition of the acoustic startle response in mice at 30 mg/kg
Cayman Chemical 1MyrIstoyl2Oleoyl3Butyry 10mg
A triacylglycerol; has been found in human breast milk
Cayman Chemical SchIsntherIn B 10mg
A lignan; inhibits formation of AGEs in vitro; decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer's disease induced by amyloid-β (1-42) at 0.1 mg/kg; increases glial expression of GLP-1 and decreases immobility time in the FST in mice; increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST
Cayman Chemical SurfenhydrochlorIde 10mg
An antagonist of cell surface glycosaminoglycans; binds to heparin, dermatan sulfate, heparan sulfate, and chondroitin sulfate and prevents heparin-induced inhibition of Factor Xa in cell-free assays; inhibits FGF2 binding to CHO cells (IC50 = 5 µM) and FGF2-induced tube formation by primary mouse endothelial cells; inhibits neural differentiation and increases pluripotency in mESCs at 5 µM
Cayman Chemical 1PalmItoyl2Oleoyl3ArachI 10mg
A triacylglycerol; has been found in lipid extracts from whole rat retina
Cayman Chemical VUF8430hydrobromIde 10mg
A histamine H4 receptor agonist (Ki = 31.6 nM); selective for histamine H4 over H1 and H3 receptors in radioligand binding assays (Kis = >1 and 1 µM, respectively) and is less active in isolated guinea pig atria, which endogenously expresses high levels of H2 receptors (pD2 = 3.8); inhibits forskolin-induced, cAMP-mediated increases in β-galactosidase activity (EC50 = 50.1 nM); enhances HCl-induced formation of gastric lesions in rats at 30 mg/kg; reduces mechanical and thermal allodynia in a mouse model of SNI-induced peripheral neuropathy
Cayman Chemical DL-CarnItIn-d9chlorIde 10mg
An internal standard for the quantification of carnitine by GC- or LC-MS
Cayman Chemical AcIbenzolar-S-methyl 10mg
A fungicide inducer of systemic acquired resistance; induces resistance in wheat concomitant with expression of wheat chemically-induced (WCI) genes at 30 g per hectare; protective against V. inaequalis in apple trees when used in combination with light IPM