Custom Peptides
Cayman Chemical 8bromo CyclIc GMPsodIM sa 10mg
A cell-permeable analog of cGMP that preferentially activates cGMP-dependent protein kinase; 1 µM-0.1 mM inhibits acetylcholine-induced increases in intracellular calcium concentrations
Cayman Chemical 7-APBhydrochlorIde 10mg
An analytical reference standard categorized as a benzofuran; a potential metabolite of 7-MAPB based on the published metabolism of 5-MAPB; intended for research and forensic applications
Cayman Chemical OuabaInhydrate 10mg
A cardiac glycoside with diverse biological activities; inhibits the Na+/K+-ATPase isoforms α1β1 and α2β1 and hERG (IC50s = 97, 90, and 15.2 nM, respectively); reduces the proliferation of PC3 and U937 cells (EC50s = 210 and 94 nM, respectively); inhibits the cytopathic effect of SARS-CoV-2 in infected Vero cells (IC50 = in vivo
Cayman Chemical HDMAPPamonIum salt 10mg
A microbial metabolite that binds the TCR on Vγ9Vδ2 peripheral blood lymphocytes with high affinity (EC50 = 0.39 nM); induces the expansion of human memory Vγ9Vδ2 T cells
Cayman Chemical Sethyl N4 trIfluoromethyl 10mg
EPIT is a selective, competitive inhibitor of nNOS having a Ki of 0.32 µM for the purified human enzyme. EPIT exhibits 115-fold and 29-fold selectivity for nNOS compared to iNOS and eNOS, respectively. It exhibits reduced inhibitory potency in whole-cell assays, possibly due to reduced intracellular uptake.{5065}
Cayman Chemical Fexinidazole 10MG
Fexinidazole is an antiparasitic agent; active against 15 strains of T. brucei, including T. b. rhodesiense, T. b. brucei, and T. b. gambiense (IC50s = 0.95-3.31 µM); inhibits the growth of L. donovani at the promastigote and axenic amastigote stages (EC50s = 5.6 and 2.8 µM, respectively) ; parasitic burden and increases survival in a mouse model of infection with benznidazole-susceptible, -partially resistant, or -resistant T. cruzi at doses ranging from 50-300 mg/kg per day
Cayman Chemical 13 14dIhdro15keto Prostag 10mg
13,14-dihydro-15-keto PGF1α is a metabolite of PGF1α that has been reported in the rat stomach.{1164} The measurement of 13,14-dihydro-15-keto PGF1α can be used as a marker of the in vivo production of PGF1α.{2106}
Cayman Chemical PhosphoramIdonsodIum salt 10mg
A natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes; also a weak inhibitor of the related zinc metalloprotease ECE (Ki = 3.5 µM); has little or no effect on a variety of other proteases
Cayman Chemical 1Ohexadecyl2Docosahexaeno 10mg
1-O-hexadecyl-2-Docosahexaenoyl-sn-glycero-3-PC is a PAF analog which contains docosahexaenoate at the sn-2 position rather than the acetate moiety found in PAF C-16. 1-O-hexadecyl-2-Docosahexaenoyl-sn-glycero-3-PC can be oxidatively fragmented resulting in the production of phospholipids with PAF-like activity.{1938,2654}
Cayman Chemical ZIprasIdonhydrochLRIde hy 10mg
An atypical antipsychotic; an agonist of 5-HT1A receptors (EC50 = 36.31 nM for inhibition of forskolin-induced adenylate cyclase activity in HeLa cells expressing human receptors), as well as an inverse agonist of 5-HT1D receptors (IC50 = 2.69 nM) and a partial agonist of 5-HT1B receptors (EC50 = 6.17 nM) in [35S]GTPγS binding assays; an antagonist at 5-HT2A and dopamine D2 receptors (Kis = 1.15 and 1.29 nM, respectively) in cell-based assays; inhibits d-amphetamine-induced hyperactivity and apomorphine-induced stereotypy in rats (ID50s = 1.53 and 2.43 mg/kg, respectively)
Cayman Chemical CynIdInchlorIde 10mg
A natural anthocyanidin with significant antioxidant activity; has vasoprotective effects and can interfere with inflammation, carcinogenesis, obesity, and diabetes
Cayman Chemical CurcumIn nalog C1 10mg
A synthetic curcuminoid and activator of TFEB; inhibits proliferation of HCT116 cells (GI50 = 4 µM); activates TFEB, inducing nuclear translocation in Neuro2a cells at 1 µM; increases LC3-II levels and promotes autophagic flux in Neuro2a cells at 1 µM; activates TFEB and increases autophagy and lysosome biogenesis in rat brain at 10 and 25 mg/kg, p.o.
Cayman Chemical 17phenl trInor ProstglndI 10mg
An F-series PG analog in which the C-1 carboxyl group has been modified to an N-diethyl amide; dialkyl amides such as a 17-p-PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids
Cayman Chemical CelIprololhydrochlorIde 10mg
A β1 adrenergic receptor antagonist and a β2 adrenergic receptor partial agonist that relaxes human arteries and veins with ED50 values of 40-50 µM in vitro; reduces myocardial infarct size and increases NO production in a rabbit model of myocardial ischemia at 1-10 mg/kg/h
Cayman Chemical GBR 12935hydrochlorIde 10mg
An inhibitor of dopamine uptake; binds to the dopamine transporter (Kd = 27.2 nM); selective for the dopamine transporter over the serotonin and norepinephrine transporters (Kds = 940 and 310 nM, respectively); it increases locomotor activity in mice at 10 mg/kg; induces gnawing in mice (ED50 = 17.1 mg/kg)