Custom Peptides
Cayman Chemical NaltrIbenmesylate 10mg
A δ2-opioid receptor inverse agonist (Ki = 0.013 nM in CHO-DG44 cells expressing the mouse receptor); selective for δ2-opioid receptors over κ- and μ-opioid receptors (Kis = 13 and 12 nM in PC12 and COS-7 cells expressing the mouse and rat receptors, respectively); induces axonal retraction in primary mouse hippocampal neurons under both normoxic and hypoxic conditions at 1 and 10 µM; an activator of TRPM7; induces calcium influx in HEK293 cells expressing mouse TRPM7 (EC50 = 20.7 µM); reduces self-administration of alcohol or alcohol mixed with saccharin or quinine in alcohol-preferring rats at 6 mg/kg
Cayman Chemical nsna wbbauna Notoptl 10mg
A furanocoumarin with diverse biological activities; a JAK2 and JAK3 inhibitor (IC50s = 9.51 and 25.2 µM, respectively); selective for JAK2 and JAK3 over TYK2 and JAK1 (IC50s = >667 and >2,000 µM, respectively); induces apoptosis and mitochondrial membrane depolarization in HL-60 cells at 40 and 60 µM; induces cell cycle arrest at the G0/G1 phase in HL-60 cells at 10, 20, and 40 µM; decreases acetic acid-induced writhing and vascular permeability in mice at 100 mg/kg; increases the duration of pentobarbital-induced sleep in mice at 10 or 30 mg/kg; reduces joint swelling, inhibits decreased talus bone volume, and reduces meniscus and talus osteoclast numbers in a mouse model of collagen-induced arthritis at 20 mg/kg per day
Cayman Chemical Ambrsentn 10mg
A nonpeptide ET-A receptor antagonist (IC50s = 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively); inhibits ET-1-induced contraction of human pulmonary and radial arteries in vitro (Kd = 0.042 and 0.11 μM, respectively); decreases PAH, RVH, and RV peak pressure in a rat model of neonatal hyperoxic lung injury (20 mg/kg per day, s.c.)
Cayman Chemical 4TRtOctylphenol monethoxy 10mg
An alkylphenolethoxylate and a degradation product of non-ionic surfactants; a non-steroidal estrogen; found in wastewater effluent
Cayman Chemical TrIlacIclIbhydrochlorIde 10mg
An inhibitor of Cdk4 and Cdk6 (IC50s = 1 and 4 nM, respectively); selective for Cdk4/cyclin D1 and Cdk6/cyclin D3 over Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, Cdk5/p35, Cdk7/cyclin H/Mat1, and Cdk9/cyclin T (IC50s = 50-4,640 nM); halts the cell cycle at the G1 phase in Cdk4/6-dependent Hs68 cells (EC50 = 30 nM); prevents camptothecin-induced DNA damage and apoptosis in Hs68 cells at 10-1,000 nM; induces reversible cell cycle arrest of HSPCs in mice at 50, 100, or 150 mg/kg; prevents etoposide-induced apoptosis of bone marrow cells in mice at 100 mg/kg; prevents 5-FU-induced myelosuppression in mice at 150 mg/kg
Cayman Chemical Lnsoprazole sulfon 10mg
A metabolite of lansoprazole; formed by metabolism of lansoprazole by CYP3A4
Cayman Chemical PIcrosIde II 10mg
A flavonoid with diverse biological activities; decreases expression of FATP5 and SCD and inhibits free fatty acid-induced lipid accumulation in HepG2 cells at 10 µM; inhibits RANKL-induced osteoclast formation in isolated murine bone marrow cells and decreases the size of bone resorption pits in bovine bone slices; inhibits LPS-induced trabecular bone loss in a mouse model of inflammatory osteoporosis at 10 and 60 mg/kg; prevents ischemia-reperfusion-induced testicular apoptosis and MDA production in a rat model of testicular torsion; reduces airway inflammation, lung mucus hypersecretion, and BALF inflammatory cell infiltration in a mouse model of house dust mite-induced allergic asthma
Cayman Chemical IsorhynchophylIn 10mg
An oxindole alkaloid with diverse biological activities; inhibits decreases in cell viability and increases in intracellular levels of ROS and MDA induced by Aβ (25-35) in PC12 cells; attenuates decreases in population spike amplitudes in the CA1 region of a rat hippocampal slice model of ischemia induced by oxygen and D-glucose deprivation at 30 and 100 μM; decreases the viability of HepG2, A549, BxPC-3, Caki-1, RPMI-8226, and 786-O cells (IC50s = 130-292 μM); induces apoptosis, inhibits cell migration in a wound healing assay, and decreases invasion in a Matrigel™ assay in HepG2 cells; decreases right ventricular end systolic pressure, hypertrophy, and fibrosis in a rat model of monocrotaline-induced pulmonary arterial hypertension at 0.1% in the diet
Cayman Chemical FezolIntnt 10mg
An NK3 receptor antagonist (IC50 = 20 nM); decreases plasma levels of LH in castrated cynomolgus monkeys at 5 mg/kg; prevents increases in body weight and food intake but does not affect uterine weight or plasma levels of estradiol, FSH, progesterone, or testosterone in ovariectomized rats at 10 mg/kg; inhibits increases in skin temperature but not core temperature, indicating regulation of hot flash-like symptoms, in ovariectomized rats at 3 or 10 mg/kg
Cayman Chemical PolysarcosIn20 10mg
An amine-functionalized hydrophilic polymer; addition to surface-grafted polymer brushes reduces protein absorption and mammalian and bacterial cell attachment
Cayman Chemical S7trIfluoroacetate salt 10mg
A peptide antagonist of the IL-6 receptor; inhibits IL-6 binding to the IL-6 receptor in a concentration-dependent manner; inhibits IL-6-induced increases in VEGF levels in C-33 A cells and RPMI-8226 B cell lymphocytes at 50 µM; reduces tumor volume in an IL-6-overexpressing C-33 A cervical cancer mouse xenograft at 50 mg/kg every two days; increases LNP glioma targeting and increases survival in a U251 glioblastoma mouse xenograft model when coupled to cysteine and LNP surfaces
Cayman Chemical RocuronIumbromIde 10mg
A non-depolarizing muscle relaxant; selectively induces neuromuscular blockade in cats (ED50s = 153, 185, 1,329, and 4,119 μg/kg for tibialis, soleus, and vagus muscles, and nictitating membranes, respectively; has a more rapid onset time than vecuronium
Cayman Chemical 5 Hydroxymethyl2deoxyurI 10mg
A nucleoside analog; inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM); acts synergistically with 5-FU against HT-29, HCT116, PANC-1, and EKVX cancer cells; inhibits HSV-1 pyrimidine 2’-deoxyribonucleoside kinase (Ki = 3.5 μM) and reduces HSV-1 viral titer to 0.05% of the control at a concentration of 200 μM; a DNA adduct formed in response to oxidative stress