Custom Peptides
Cayman Chemical SAR441255sodIum salt 10mg
A peptide agonist of GLP-1R, GIPR, and GCGR; induces cAMP accumulation in HEK293 cells expressing human GLP-1R, GIPR, or GCGR (EC50s = 1.03, 0.73, and 1.01 pM, respectively); reduces body weight in a mouse model of high-fat diet-induced obesity from 1-30 UG/kg; reduces body weight and blood HbA1c levels in high-fat diet-induced obese diabetic cynomolgus monkeys at 11 UG/kg
Cayman Chemical oxLIg-1technIcal grade 10mg
A lipid component of oxLDL; binds to the ligand-binding domain of PPARγ, an effect that can be reversed by troglitazone, and also binds to CD36, at 50 UG/ml; increases cholesterol efflux and protein levels of LXRα and ABCA1 in THP-1 macrophages at 20 UG/ml; liposomes containing oxLig-1 and complexed with apolipoprotein H, bind to an anti-apolipoprotein H antibody, which mediates uptake by J774A.1 macrophages; decreases oleic acid-induced intracellular lipid accumulation in HepG2 cells, as well as hepatic lipid accumulation in mice fed a high-fat diet; serum levels of IgG autoantibodies targeting a complex of oxLig-1 and apolipoprotein H are increased in patients with antiphospholipid syndrome with a history of arterial thrombosis
Cayman Chemical DImethIndenmaleate 10mg
A histamine H1 receptor antagonist (Ki = 1.5 nM); selective for histamine H1 receptors over M1 mAChRs and 5-HT receptor subtype 5-HT2A (Kis = 64 and 2,400 nM, respectively); alone or in combination with icodextrin decreases adhesions between the abdominal wall and intraperitoneal viscera and local vascularization following surgical-induced abdominal trauma in rabbits at 0.1 mg/kg
Cayman Chemical VInorelbIntartrate 10mg
An inhibitor of microtubule polymerization that blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation (IC50 = 1.25 nM)
Cayman Chemical Arhalofenate 10mg
A prodrug form of a PPARγ partial agonist; has weak transactivation and strong transrepression activity; reduces fasting plasma glucose levels in ob/ob mouse and ZDF rat models of type 2 diabetes at 125 and 100 mg/kg, respectively; decreases fasting plasma free fatty acid, triglyceride, and cholesterol levels in ZDF rats without increasing body weight at 100 mg/kg; prevents leukocyte and neutrophil infiltration and IL-1β, IL-6, and CXCL1 production in air pouch fluid in a mouse model of gout at 250 mg/kg
Cayman Chemical VarenIclIntartrate 10mg
An agonist of α7 and α4β2 nAChRs (EC50s = 18 and 2.3 µM, respectively)
Cayman Chemical 13 14dIhydro PROSGlnDN F 10mg
An analog of PGF2α which has no unsaturation in the lower side chain; causes luteolysis in hamsters with a potency five times higher than PGF2α
Cayman Chemical 16-EpIestrIol 10mg
A metabolite of estrone; inhibits the growth of carbapenem-resistant A. baumannii at 200 UG/ml; inhibits carrageenan-induced paw edema in rats at 20 mg/kg; does not increase plasma or liver glucose levels in adrenalectomized rats at 240 UG/animal
Cayman Chemical Cyclocarya palurus Afzln 10mg
A polyphenolic glycoside flavone with diverse biological activities; scavenges DPPH radicals (IC50 = 6.44 μg/ml); active against S. aureus, P. aeruginosa, S. typhi, C. albicans, C. parapsilosis, and C. neoformans (MICs = 8, 16, 2, 16, 4, and 4 μg/ml, respectively); inhibits the proliferation of A549, SKOV3, and SK-MEL-2 cells (EC50s = 40.6, 34.5, and 33.9 μg/ml, respectively); reduces the number of eosinophils, other inflammatory cells, and total cells, as well as the levels of IL-4, IL-5, and IL-13, in BALF in a mouse model of allergic asthma at 26 mg/kg per day
Cayman Chemical HypophylnthIn 10mg
An active principle of P. amarus that has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity
Immunology Consultants anti-Glu-Glu Antibody (Rabbit) - Affinity Purified
RGLU‑45A is an affinity‑purified rabbit polyclonal antibody specific for the Glu‑Glu tag, a short epitope used in recombinant protein expression and detection. The purification process enriches high‑affinity antibodies, ensuring strong specificity and reduced background in Western blotting, ELISA, immunoprecipitation, and immunofluorescence applications. Produced by Immunology Consultants and supplied in a 1 mg format, RGLU‑45A provides a high‑quality reagent for researchers working with Glu‑Glu–tagged proteins.
Cayman Chemical 1DocosahexaenoylracglycRo 10mg
A monoacylglycerol; reduces ET-1-induced smooth muscle tension in isolated HPAs at 1-30 µM; reduces ET-1-induced increases in HPA cell proliferation and VEGF levels
Cayman Chemical CPTH6hydrobromIde 10mg
A thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP; blocks the acetylation of H3/H4 histones and α-tubulin in several leukemia cell lines