Custom Peptides
Cayman Chemical AKOS B018304 10mg
A derivative of 1,3-thiazolidin-4-one; inhibits the binding of ΔFosB to an oligonucleotide containing the Cdk5-AP-1 consensus site in a cell-free assay (IC50 = 10.1 µM); induces ΔFosB- and ΔFosB/JunD-mediated gene transcription in a reporter assay using Neuro2a cells at 12.5 µM
Cayman Chemical AMKhydrochlorIde 10mg
An active metabolite of melatonin; scavenges singlet oxygen in vitro at 200 µM; inhibits epinephrine- and arachidonic acid-induced production of PGE2 and PGD2 in ovine seminal vesicle; inhibits LPS-induced increases in COX-2 levels in RAW 264.7 macrophages at 500 µM; decreases MPTP-induced increases in lipid peroxidation in the cytosol and mitochondria from substantia nigra and striatum in a mouse model of MPTP-induced Parkinson's disease at 20 mg/kg
Cayman Chemical aDGlucose1 6bIsphosphate 10mg
A bis-phosphorylated derivative of α-D-glucose; has roles in carbohydrate metabolism; the product of the reaction of glucose 1- or 6-phosphate with PGM2LI in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate; a cofactor for the bacterial enzyme phosphopentomutase; has been used in the study of carbohydrate metabolism
Cayman Chemical 8hydroxy DPAThydrobromIde 10mg
A 5-HT1A receptor agonist (EC50 = 12 nM in rat hippocampal membranes); enhances the behavioral effects of Δ9-THC in rhesus monkeys in a discriminant stimulus-shock test (0.178 mg/kg, i.v.); reduces baclofen-induced aggression in mice when administered directly to the dorsal raphe nucleus; impairs contextual fear in mice when administered prior to training (0.5 mg/kg, s.c); reduces apnea in a methyl-CpG-binding protein 2-deficient mouse model of Rett syndrome (50 UG/kg i.p.)
Cayman Chemical 19-NoretIocholnolon 10mg
An analytical reference standard categorized as an anabolic androgenic steroid metabolite of nandrolone; intended for research and forensic applications
Cayman Chemical ValerylLcarnItInchLRIde 10mg
A short-chain acylcarnitine; levels increase in the serum of rhesus monkeys following exposure to 7 and 10 Gy of ionizing radiation
Cayman Chemical 4methoxy5HydroxycnthIn6 10mg
An alkaloid with anti-inflammatory activity; reduces LPS-induced TNF-α release from, and NO production in, RAW 264.7 macrophages at 10, 30, and 100 µM; reduces paw swelling in a rat model of CFA-induced arthritis at 9 and 27 mg/kg; reduces colonic inflammatory cytokine levels and maintains mucosal barrier function in a mouse model of DSS-induced colitis from 25-100 mg/kg
Cayman Chemical Salva plba . B. upafoln 10mg
A flavonoid with diverse biological activities; inhibits iron-dependent lipid peroxidation in a cell-free assay (IC50 = 7.9 µM); inhibits PrP106-126 aggregation in a cell-free assay and reduces PrP106-126-induced cell death in SH-SY5Y cells from 50-150 µM; inhibits the production of hemolysin and leukocidin by MSSA and MRSA and reduces S. aureus-induced hemolysis of erythrocytes in isolated rabbit whole blood at 100 µM; reduces the number of lung CFUs and increases survival in a mouse model of MRSA infection at 100 mg/kg; reduces angiogenesis and tumor volume in a Hep3B mouse xenograft model at 60 mg/kg
Cayman Chemical AzasetronhydrochlorIde 10mg
An orally bioavailable 5-HT3 antagonist (Ki = 2.9 nM); selective for 5-HT3 over 5-HT1A and 5-HT2 (IC50 = >10 μM for both), as well as D1, D2, α1-, and α2-adrenergic receptors (IC50s = >10 μM); binds to H1 receptors (IC50 = 4.4 μM); inhibits 5-HT-induced contractions in isolated guinea pig ileum (pA2 = 7.04) and isolated rabbit heart (pA2 = 10.06); inhibits cisplatin-induced emesis in dogs and doxorubicin/cyclophosphamide-induced emesis in ferrets at 1 mg/kg
Cayman Chemical 15mthyl PalmItIc ACD mthy 10mg
A methylated fatty acid methyl ester; has been found in S. zeai sea sponges as the fatty acyl component of zeamide, oolong tea, and P. sulcate extract
Cayman Chemical DL-erythrothreo SphngnIn 10mg
A mixture of sphinganine (d16:0), L-erythro sphinganine (d16:0), D-threo sphinganine (d16:0), and L-threo sphinganine (d16:0); decreased in rats following long-term, low-dose administration of dimethoate and is used as a biomarker for dimethoate exposure; found in the fermentation broth of Bacterium SRCnm
Cayman Chemical XL413hydrochlorIde 10mg
A potent inhibitor of Cdc7 (IC50 = 3.4 nM); >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively; inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively); inhibits Cdc7-specific phosphorylation of MCM2 and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells; inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model at 10, 30, and 100 mg/kg
Cayman Chemical 1Stearoyl2Oleoyl3LInoleo 10mg
A triacylglycerol; has been found in peanut and soybean oils as well as ostrich and emu oils; has been used as a substrate for soybean lipoxygenase in cell-free assays