Custom Peptides
Cayman Chemical BIO1211trIfluoroACTAte sa 10mg
A peptide inhibitor of α4β1 integrin (IC50 = 0.004 µM); selective for α4β1 integrin over α4β7 (IC50 = 2 µM), as well as α1β1, α5β1, α6β1, αLβ2, and αIIBβ3 (IC50s = >100 µM for all); binds to α4β1 (IC50 = 1 nM); inhibits Jurkat cell adhesion (IC50 = 4 nM); prevents carbachol-induced airway hyperresponsiveness in an ovine model of allergy-induced asthma at 3 mg/animal inhaled
Cayman Chemical QuInaprIlat 10mg
An ACE inhibitor (IC50 = 0.06 nM) and active metabolite of quinapril; inhibits LPC-induced calcium overload and rod to round cell shape change in isolated rat cardiomyocytes at 20 and 50 µM; reduces the frequency of ventricular fibrillation in a dog model of myocardial ischemia and reperfusion injury at 3 UG/kg; reduces blood pressure and proteinuria in rat models of uranyl nitrate- or 5/6 nephrectomy-induced chronic renal failure at 0.1 mg/kg
Cayman Chemical 5-ndrostentrIol 10mg
An active metabolite of DHEA; reduces radiation-induced lethality and induces hematopoietic recovery from surviving stem cells in mice at 0.75 mg/25 g body weight; increases survival in a rat model of surgical trauma-induced sepsis at 40 mg/kg; urinary levels are increased in women with androgenic alopecia
Cayman Chemical 2-ThIocytIdIn 10mg
A modified nucleobase; an intermediate in the synthesis of pyrimidine β-ribonucleosides and β-ribonucleotides
Cayman Chemical Coydals duls max. Coydn 10mg
An aporphine alkaloid with diverse biological activities; inhibits the proliferation murine L1210 lymphocytic leukemia, B16/F10 melanoma, and P388 leukemia cells from 10-100 UG/ml; binds to μ-opioid receptors (Ki = 2.82 µM) and induces [35S]GTPγS binding in CHO cells expressing human μ-opioid receptors (EC50 = 0.51 µM); active against L. donovani promastigotes (IC50 = 26.7 µM)
Cayman Chemical 3Odemethyl ThIocolchIcIn 10mg
A degradation product of thiocolchicoside; formed under acidic and basic conditions
Cayman Chemical IndolIcIdIntrIfluoROCTAte 10mg
An antimicrobial peptide; active against MDR-EAEC (MICs = 32 µM for all); active against S. cerevisiae, T. beigelii, and C. albicans (MICs = 5-10, 2.5-5, and 5-10 µM, respectively); reduces viral replication of HIV-1 in MT-2 cells from 67-100 UG/ml; increases survival of MDR-EAEC-infected G. mellonella larvae
Cayman Chemical C16 dIhydro CRamIDd18 01 10mg
A precursor in the de novo synthesis of C16 ceramide; inhibits C16 ceramide-induced membrane permeabilization in rat liver mitochondria and channel formation in liposomes; biologically inactive as a single agent
Cayman Chemical LnIfIbrnor 10mg
A PPAR agonist (EC50s = 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively); increases β-oxidation in Huh-7 and C2C12 cells at 1 and 3 µM, respectively; reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes at 10 and 30 mg/kg for five days; increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of NASH
Cayman Chemical Scutlaa bacalns Ngltn 10mg
A flavonoid with diverse biological activities; inhibits biofilm formation by S. aureus, B. subtilis, P. aeruginosa, and E. coli at 32 UG/ml; rinduces cytotoxicity in SW460 and DLD-1 cancer cells (IC50s = 29.41 and 30.93 µM, respectively) but not HT-29 or HepG2 cancer cells (IC50s = >40 µM for both); decreases LPS-induced NO production and secreted TNF-α and IL-1β levels in J774A.1 macrophages at 0.01 µM; alone and in combination with NGF increases neurite outgrowths, levels of GAP43, and decreases serum deprivation-induced death in PC12 cells at 10 µM
Cayman Chemical Chromn 1hydrochLRIde hydr 10mg
A ROCK2 inhibitor (IC50 = 50s = 1,740 and 127 nM, respectively); inhibits phosphorylation of MLC in a cell-based assay (IC50 = <4 nM)
Cayman Chemical Stphna yuns Crbn 10mg
An aporphine alkaloid; an antagonist of α7 nAChRs (IC50 = 19.1 µM); inhibits INa in isolated guinea pig ventricular myocytes (IC50 = 283 µM); active against Gram-positive bacteria (MICs = 0.213-0.312 g/L); inhibits the LPS-induced production of TNF-α, IL-6, NO, and PGE2 in RAW 264.7 macrophages at 29.5 µM; inhibits the proliferation of A549, MDA-MB-231, MCF-7, SKOV3, and Caov-3 cells; reduces TNF-α induced invasion and migration of A549 cells; prevents scopolamine-induced memory deficits in the Morris water maze in mice at 25 mg/kg
Cayman Chemical PMX53trIfluoroACTAte salt 10mg
A C5a receptor antagonist (IC50 = 0.3 µM); inhibits C5a-induced secretion of MPO in isolated human PMNs; inhibits vascular leakage, PMN infiltration, and peritoneal TNF-α and IL-6 production in a rat model of peritoneal Arthus reaction at 10 mg/kg; reduces body weight loss and anorexia and inhibits striatal degeneration in a rat model of 3-NP-induced Huntington’s disease; reduces atherosclerotic lesion size and lipid content in ApoE-/- mice at 3 mg/kg
Cayman Chemical CInamoylglycIn 10mg
A metabolite of trans-cinnamic acid; urinary levels are decreased in a mouse model of piperacillin- and tazobactam-induced gut microbiota colonization resistance; serum levels are increased in patients with CKD
Cayman Chemical 3hydroxy9 10DImethoxypTRo 10mg
A flavonoid; inhibits PDGF-BB-induced proliferation of, and DNA synthesis in, A-10 vascular smooth muscle cells (IC50s = 10 and 1 µM, respectively)