Custom Peptides
Cayman Chemical AMPR22trIfluoroACTAte sal 10mg
An antimicrobial peptide; active against S. aureus, MRSA, P. aeruginosa, and carbapenem-resistant P. aeruginosa (MBCs = 2, 2, 2, and 4 UG/ml, respectively); induces bacterial outer membrane permeability and ATP leakage to the extracellular space in S. aureus and P. aeruginosa; increases survival in a mouse model of sepsis induced by S. aureus at 10 mg/kg
Cayman Chemical Cardol trIen 10mg
A phenol from cashew nut shell liquid; inhibits mushroom tyrosinase (IC50 = 2.2 µM); kills 25, 75, and 100% of S. mansoni worms after 24 hours when used at concentrations of 50, 100, or 200 µM, respectively; has been used as a starting material for the synthesis of bis-benzoxazines
Cayman Chemical E6446hydrochlorIde 10mg
A TLR7 and TLR9 antagonist (IC50s = 1.78 and 0.01 µM, respectively); selective for TLR7 and TLR9 over TLR4 (IC50 = 10.58 µM); inhibits CpG ODN2216- or RNA40-induced IL-6 production in isolated mouse BMDCs; prevents increases in left ventricle chamber size and cardiac fibrosis in a mouse model of transverse aortic constriction-induced heart failure at 1.5 mg/animal; increases survival and reduces increases in right ventricular systolic pressure and hypertrophy in a rat model of monocrotaline-induced pulmonary hypertension at 10 mg/kg; has been used to enhance the transfection efficiency of cell-penetrating peptides for the delivery of mRNA in vitro
Cayman Chemical Cyprus rotundus aCypron 10mg
A sesquiterpenoid with diverse biological activities; inhibits LPS-induced nuclear translocation of p65, as well as LPS-induced production of PGE2 and IL-6, in RAW 264.7 cells; reduces hydrogen peroxide-induced production of ROS and apoptosis in SH-SY5Y cells at 15 and 30 µM; reduces the production of HBsAG in infected HepG2.2.15 cells (IC50 = 274.7 µM)
Cayman Chemical JWH 122 N 4pentenyl nalog 10mg
Structurally related to JWH 122, differing only by the presence of a terminal double bond on the acyl chain; intended for forensic and research applications
Cayman Chemical BzNleKRRAMChydrochlorIde 10mg
A fluorogenic substrate for YFV NS3 or DV NS2B/3 serine proteases; AMC is released upon enzymatic cleavage by YFV NS3 or DV NS2B/3 serine proteases and its fluorescence can be used to quantify YFV NS3 or DV NS2B/3 serine protease activity; ex/em = 340-360/440-460 nm, respectively
Revvity Health Sciences Inc AlphaLISA SureFire Ultra Human & Mouse Total ATF2 Detection Kit, 500 Assay Points
AlphaLISA SureFire Ultra Human & Mouse Total ATF2 Detection Kit, 500 Assay Points
Cayman Chemical 3-PropylxnthIn 10mg
A xanthine derivative that antagonizes adenosine receptors (Kis = 44, 32, and 6.3 µM for A1, A2A, and A2B, respectively) and cAMP PDE(Ki = 42 µM); induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness
Cayman Chemical CholSTRyl DocosaPNtaenoat 10mg
A cholesterol ester; elevated in liver, plasma, and skeletal muscle of ACBP knockout mice
Cayman Chemical ThymosIn a1humnmousera 10mg
An immunomodulator peptide formed from the cleavage of prothymosin α; inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo; increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures at 20 μM; inhibits the growth and migration of H1299, NL9980, and L9981 NSCLC cells that express high PD-L1 levels but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels; decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model at 20 mg/kg per day; increases IDO1 expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a CFTRF508del/F508del mouse model of cystic fibrosis and chronic A. fumigatus infection at 200 μg/kg
Cayman Chemical SynthetIc PrunIn 10mg
A flavonoid glycoside with diverse biological activities; inhibits NA activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 3 and 4.53 µM, respectively); scavenges DPPH radicals in a cell-free assay at 2 µM; inhibits the activity of PTP1B (IC50 = 5.5 µM for the human enzyme); increases insulin-induced glucose uptake in insulin-resistant HepG2 cells; inhibits proliferation of, and induces apoptosis in, HL-60 cells
Cayman Chemical 4FluoroIsocathInonhydroch 10mg
A compound which structurally mimics substituted cathinones and phenethylamines; a potential designer drug of abuse; intended for research and forensic applications
Cayman Chemical 1 3ChLRophenylpIperazIn 10mg
An analytical reference standard categorized as a piperazine; a metabolite of trazodone; has been found in 3,4-MDMA tablets seized by law enforcement; intended for research and forensic applications
Cayman Chemical EdaglItazon 10mg
A PPARγ agonist; activates PPARγ in a reporter assay using CV-1 cells expressing murine PPARγ2 from 0.1-1 μM; increases [3H]2-deoxyglucose transport in the presence and absence of insulin and increases glycogen synthesis in the presence of insulin in soleus muscle strips isolated from obese rats at 1, 5, and 25 μM
Cayman Chemical CXCL974-103humntrIfl 10mg
A CXCL9-derived peptide; binds to heparin in a cell-free assay (Kd = 3.1 nM); inhibits the binding of CXCL8 or CXCL11 to heparin, as well as CCL2 binding to heparan sulfate; reduces the cytopathogenic effect of RSV in HeLa cells, HSV-1 in HEL cells, and dengue virus serotype 2 in HMEC-1 cells (EC50s = 23, 15, and 11 µM, respectively); inhibits CXCL8 (1-77)- or monosodium urate-induced neutrophil extravasation to the tibiofemoral articulation in mouse models of acute inflammation or gout, respectively, at 100 UG/animal; increases survival and decreases liver neutrophil infiltration and necrosis in a mouse model of acetaminophen-induced liver injury; decreases BALF neutrophil infiltration and IL-1β levels, but does not reduce lung bacterial burden, in a mouse model of K. pneumoniae-induced pneumonia