Custom Peptides
Cayman Chemical 7keto DehydroepIndrosTRon 10mg
An analytical reference standard categorized as a steroid metabolite of dehydroepiandrosterone; reduces ethanol consumption without the hormone-generating effects of dehydroepiandrosterone in rats; intended for research and forensic applications
Cayman Chemical MavorIxafor 10mg
A CXCR4 antagonist (IC50 = 13 nM in a radioligand binding assay); selective for CXCR4 over CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2 (IC50s = >10 µM for all); reduces CXCL12-induced chemotaxis of CCRF-CEM T cells (IC50 = 19 nM); inhibits fusion of CHO-K1 cells expressing gp120 to P4 MAGI cells IC50 = 1.5 nM; decreases HIV-1 NL4.3 viral replication in MT-4 cells and isolated human PBMCs (IC50s = 2 and 9 nM, respectively)
Cayman Chemical DerenofylIn 10mg
An adenosine A1 receptor antagonist (Ki = 1 nM); selective for adenosine A1 over A2A, A2B, and A3 receptors (Kis = 398, 3,981, and 200 nM, respectively); decreases adenosine A1 receptor-mediated adenosine-induced bradycardia in rats (ED50 = 0.49 mg/kg) but reduces A2 receptor-mediated adenosine-induced hypotension by only 44.6% at an intravenous dose of 5 mg/kg; prevents increases in heart levels of collagen I and III in nephrectomized rats at 10 mg/kg per day; reduces relative plaque counts in a Zika virus plaque-forming assay in A549 cells (IC50 = 58.6 nM) in an adenosine A1 receptor-independent manner
Cayman Chemical LX7101hydrochlorIde 10mg
A potent inhibitor of LIMK1, LIMK2, ROCK1, and ROCK2 kinases (IC50s = 32, 4.3, 69, and 32 nM, respectively); selective, showing no cross reactivity in a panel of binding assays including 78 receptors, at a concentration of 10 μM; topical administration (3 μl of 1 mg/ml solution) to the eye reduces intraocular pressure in a dexamethasone-induced mouse model of glaucoma
Cayman Chemical Dynarrestin 10MG
A dynein inhibitor; inhibits dynein 1-dependent microtubule gliding (IC50 = 5 µM) and dynein 2-dependent intraflagellar transport in mIMCD-3 cells at 0.125 and 1.25 µM; decreases the number of cells in metaphase, anaphase, or telophase in asynchronous COS-7 cells (IC50 = 6.25 µM); inhibits the proliferation of primary Ptch+/- murine medulloblastoma cells (IC50 = 0.068 µM) and the expression of GLI1 in purmorphamine-stimulated KYSE-180 cells (IC50 = 0.21 µM)
Cayman Chemical 5-O-DemethylnobIletIn 10mg
A flavonoid with diverse biological activities; induces neurite outgrowth and the expression of the genes encoding GAP43 and synaptophysin in PC12 cells from 10-20 µM; reduces triglyceride levels in 3T3-L1 preadipocytes from 2.5-20 µM; decreases body weight, intra-abdominal fat, plasma and liver triglyceride levels, and plasma cholesterol levels in a mouse model of high-fat diet-induced obesity at 25 mg/kg; reduces hepatic fibrosis and MDA levels in a mouse model of carbon tetrachloride-induced liver injury; reduces EAr edema, inflammatory cell infiltration, and papillar fibrosis in a mouse model of TPA-induced inflammation
Cayman Chemical 12-EpInapelIn 10mg
A diterpenoid alkaloid; has antiarrhythmic activity in a rat model of aconitine-induced arrhythmia and antifibrillatory activity in a mouse model of aconitine-induced cardiac fibrillation (ED50s = 8 and 20 mg/kg, respectively)
Cayman Chemical 3 3 5-TrIIodo-L-thyronIn 10mg
A thyroid hormone that is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than T3; activates TRΔα1, a native form of TRα that lacks a nuclear localization signal and functions in the cytoplasm, initiating actin polymerization
Cayman Chemical ThIocolchIcIn 10mg
An inhibitor of microtubule assembly (IC50 = 2.5 µM); inhibits binding of colchicine to tubulin (Ki = 0.7 µM); inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM)
Cayman Chemical SotaglIflozIn 10mg
An SGLT inhibitor (IC50s = 36 and 1.8 nM for human SGLT1 and SGLT2, respectively); increases plasma GLP-1 and PYY levels, as well as glucose levels in the small intestine, cecum, and colon, in mice at 60 mg/kg; decreases blood glucose levels in a mouse model of cyclophosphamide-induced diabetes at 2 and 30 mg/kg
Cayman Chemical ParaxnthIn 10mg
An active metabolite of caffeine; an adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 µM, respectively); increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by CPA or CGS 21680 in rats not habituated to caffeine at 30 mg/kg; promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety
Cayman Chemical SB-743921hydrochlorIde 10mg
An Eg5 inhibitor (Ki = 0.5 nM for microtubule-stimulated ATPase activity); inhibits the growth of various cancer cell lines in vitro (GI50s = 22-82 nM); induces complete tumor regression in a COLO 205 mouse xenograft model and partial regression in MCF-7, SK-MES, H69, and OVCAR-3 mouse xenograft models; reduces tumor volume in a DLBCL mouse xenograft model from 2.5-10 mg/kg
