Custom Peptides
Cayman Chemical AMARA PeptIDtrIfluoROCTA 10mg
A biflavonoid with diverse biological activities inhibits the aggregation of AB40 in vitro (IC50 9.5 M) promotes pre-mRNA splicing of the genes encoding Mcl-1 and eIF4a and inhibits pre-mRNA splicing of the genes encoding Hsp40 and RIOK3 in NB4 cells at 10 UM increases protein SUMOylation in HEK293 cells at 10 UM reduces the cytopathic effect of the influenza A subtypes H1N1 and H1N3 influenza B parainfluenza type 3 and RSV (IC50s 1.4 1.3 1.2 1 and 2.5 Ug/ml respectively) inhibits the migration and invasion of and induces apoptosis in KYSE-150 cells from 10-40 UM reduces tumor volume in a KYSE-150 mouse xenograft model at 25 or 50 mg/kg
Cayman Chemical TRPV1TatrIfluoroacetAT s 10mg
A bacterial glycerol metabolite with antibacterial activity is produced by L. reuteri during exposure to live or UV-killed E. coli active against E. coli and several species of Bacteroides Bifidobacterium and Eubacterium (MICs 1.9-15 mM) as well as C. difficile and B. vulgatus (MICs C. difficile at 2.5 mM alters the bacterial composition of and VOCs produced by the mouse fecal microbiome
Cayman Chemical SLF1081851hydrochlorIde 10mg
A GAT inhibitor (IC50s 2.6 310 29 and 16 UM for mouse GAT-1 GAT-2 GAT-3 and GAT-4 respectively) does not bind GABAA or GABAB receptors (IC50s 100 UM for both) but does bind the adenosine A3 receptor (IC50 0.01 UM) inhibits GABA uptake in isolated rabbit choroid plexus (IC50 244 UM) inhibits LDH release (EC50 ~5 UM) and aggregation of htt-N63-148Q in PC12 cells intraventricular administration (300 Ug/animal) decreases tail flick reaction time in a rat model of morphine-induced analgesia
Cayman Chemical CrostIdetrIfluoroacetAT s 10mg
An alkaloid with anticancer and antiviral activities cytotoxic to HL-60 NB4 MOLT-4 K562 Jurkat and Raji cells (IC50s 4.91 16.88 7.09 22.59 5.54 and 18.08 UM respectively) induces mitochondrial apoptosis as well as impairs lysosomal acidification and autophagic flux in HL-60 cells from 5-20 UM reduces infectivity and HBsAg secretion in HBV-infected HepG2 2.2.15 cells from 10-100 UM reduces viral infectivity in Zika virus-infected Vero cells at 20 40 and 80 UM
Cayman Chemical ARUK3001185 10mg
An intermediate in the synthesis of sildenafil a potential impurity found in commercial preparations of sildenafil
Cayman Chemical CecropIn AtrIfluoroacetAT 10mg
A byproduct of hemoglobin degradation formed via oxidation of urobilinogen and is excreted in both urine and feces by mammals has been used as a marker of human waste contamination in recreational and source waters
Cayman Chemical McaRPPGFSAFK DnpOHtrIflu 10mg
An inhibitor of Notch signaling binds to the BTD domain of RBPJ and inhibits the assembly of the RBPJ-NICD transcription complex inhibits ligand-induced Notch signaling in HeLa cells expressing mouse Notch1 -2 -3 or -4 (IC50s 1.5 0.9 1.1 and 2.9 UM respectively) reduces expression of the Notch target genes HES1 MYC and DTX1 in RPMI-8402 T-ALL cells reduces tumor volume and increases survival in an HCC-1187 mouse xenograft model at 25 mg/kg
Cayman Chemical Estron 3sulfATsodIum sal 10mg
An analytical reference standard categorized as an opioid induces respiratory depression in mice intended for research and forensic applications
Cayman Chemical McaAVLQSGFRK DnpKNH2tr 10mg
An intermediate in arginine and proline metabolism a precursor in the synthesis of Y-glutamic semialdehyde
Cayman Chemical F9170trIfluoroacetAT salt 10mg
A metabolite of bilirubin and a precursor in the biosynthesis of stercobilin fecal levels are increased in patients withBthalassemia
Cayman Chemical MELK-8ahydrochlorIde 10mg
An antiviral agent inhibits replication of wild-type HBV and drug-resistant HBV strains rtA181T rtA181V and rtN236T (IC50s 146 145 161 and 131 nM respectively) inhibits the formation of viral capsids and decreases viral core protein levels in HBV-infected HepG2 and HepG2.2.15 cells at 1 and 10 UM inhibits HBV replication and reduces the levels of viral intracellular core antigens in mice inoculated with HepAD38 cells at 7.5-60 mg/kg
Cayman Chemical 5FAMLPETGGtrIfluoroACTAt 10mg
An internal standard for the quantification of homocitrulline by GC- or LC-MS
Cayman Chemical A20FMDV2trIfluoROCTAte sa 10mg
An EIF2AK3 activator increases phosphorylation of eIF2a at serine 51 in HT-29 and MCF-7 cells at 10 UM an effect not seen in cells transfected with EIF2AK3 siRNA reduces phosphorylation of Rb in HT-29 cells (EC50 5.1 UM) rapidly reduces the level of cyclin D1 in HT-29 cells at 10 UM inhibits the growth of HT-29 colon carcinoma cells (GI50 2.1 UM)