Custom Peptides
Cayman Chemical ArachIdonyl SerInol 10mg
A 2-AG analog with increased stability; approximately a log less potent as a CB1 receptor agonist than 2-AG
Cayman Chemical ZInquIn ethyl ester 10mg
A cell-permeable, quinolone-based fluorescent probe used as a zinc indicator (excitation 368 nm, emission 490 nm); used to monitor intracellular zinc fluxes associated with apoptosis
Cayman Chemical JWH 073 4mthylnphthyl nl 10mg
Differs structurally from JWH 073 by having a methyl group added at the 4 position of the naphthyl rings; a similar addition to JWH 018 results in an analog which has higher affinities for both cannabinoid receptors
Cayman Chemical JWH 018 N 1 2dImthylPRYl 10mg
Differs from JWH 018 structurally by having a 1,2-dimethylpropyl chain, rather than a pentyl chain, extending from the indole group; intended for forensic purposes
Cayman Chemical trns2 5bIs 3 4 5TrIme 10mg
trans-BTP Dioxolane is a PAF receptor antagonist. This compound demonstrates competitive antagonism of PAF in a rabbit washed platelet assay (Ki = 0.3 µM).{824}
Cayman Chemical CP 100 356hydrochlorIde 10mg
A P-glycoprotein inhibitor (IC50 = 0.5 µM); selective for P-gp over MRP2 at 15 µM, CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 (IC50s = >50 µM for all), and OATP2B1 (IC50 = ~66 µM) but does inhibit BCRP (IC50 = 1.5 µM); increases the rate of prazosin clearance in rats at 24 mg/kg when administered in combination with prazosin
Cayman Chemical 11-DehydrocortIcosteron 10mg
An endogenous mineralocorticoid; increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner; decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of carbenoxolone-induced 11β-hydroxysteroid dehydrogenase inhibition; chronic administration increases plasma glucocorticoids levels, body weight gain, and adiposity, as well as induces insulin resistance in mice
Cayman Chemical ttramthylrhodamIn IsoTHOc 10mg
An amine-reactive derivative of rhodamine that is used as a fluorescent label for antibodies and other probes (ex/em max = 552/575 nm)
Cayman Chemical SB-216641hydrochlorIde 10mg
A 5-HT1B receptor antagonist; binds to 5-HT1B receptors (Ki = 1 nM); selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1E, and 5-HT1F receptors in radioligand binding assays (Kis = 500, 25, >1,000, and >1,000 nM, respectively); reduces 5-HT-induced inhibition of forskolin-induced cAMP production in CHO cells expressing human 5-HT1B receptors from 1-1,000 nM
Cayman Chemical CID-5721353 10mg
A Bcl-6 inhibitor (Ki = 147 µM); selective for Bcl-6 over Kaiso, HIC1, and PLZF at 50 µM; cytotoxic against SU-DLH-6, SU-DLH-4, Farage, OCI-LY7, OCI-LY1, and OCI-LY10 DLBCL cells (GI50s = 0.024-0.936 mM); increases expression of ATR, TP53, CD69, p21, and CD44 in SU-DLH-6 and SU-DHL-4 cells at 50 µM; reduces tumor growth in OCI-LY7 and SU-DHL-6 mouse xenograft models at 50 mg/kg
Cayman Chemical 1R 9SHydrastIn 10mg
An inhibitor of dopamine biosynthesis (IC50 = 20.7 µM in PC12 cells); inhibits tyrosine hydroxylase activity; inhibits dopamine release in the presence of a high extracellular K+ level (IC50 = 66.5 µM); inhibits L-type and caffeine-activated store-operated Ca2+ channels; prevents Ca2+ leakage from intracellular stores
Cayman Chemical MyrIstelaIdIc AcId 10mg
A monounsaturated ω-5 fatty acid; the trans isomer of myristoleic acid; converted to myristelaidoyl CoA at a faster rate than myristoleic acid to myristoleoyl CoA
Cayman Chemical L-CycloserIn 10mg
An inhibitor of sphingolipid synthesis and aminotransferases; inhibits bacterial SPT 100 times more potently than D-cycloserine; inhibits SPT activity up to 86% in a dose-dependent manner in mouse brain microsomes following administration of doses ranging from 25-200 mg/kg; inhibits SPT in rabbit aorta and several aminotransferases in vitro and in vivo in rat; inhibits the growth of M. tuberculosis through branched chain aminotransferase inactivation, and it does so more rapidly and potently than D-cycloserine (MICs = 0.3 and 2.3 UG/ml, respectively)
Cayman Chemical BeraprostsodIum salt 10mg
Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 UG in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension.{8136} Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.{8137,8139}
Cayman Chemical 7fluoro TryptamInhydrochl 10mg
A tryptamine derivative that potentially agonizes 5-HT serotonin receptors; intended for research and forensic applications